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Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation.

Maier JAH, Möhrle R, Jeltsch A.

Nat Commun. 2017 May 24;8:15336. doi: 10.1038/ncomms15336.


Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.

Weirich S, Kudithipudi S, Jeltsch A.

Mol Oncol. 2017 Apr;11(4):373-387. doi: 10.1002/1878-0261.12041. Epub 2017 Mar 10.


Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Stepper P, Kungulovski G, Jurkowska RZ, Chandra T, Krueger F, Reinhardt R, Reik W, Jeltsch A, Jurkowski TP.

Nucleic Acids Res. 2017 Feb 28;45(4):1703-1713. doi: 10.1093/nar/gkw1112.


Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.

Jeltsch A, Jurkowska RZ.

Nucleic Acids Res. 2016 Oct 14;44(18):8556-8575. Epub 2016 Aug 12. Review.


Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody.

Kungulovski G, Mauser R, Reinhardt R, Jeltsch A.

Epigenetics Chromatin. 2016 Mar 22;9:11. doi: 10.1186/s13072-016-0061-9. eCollection 2016.


Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity.

Lukashevich OV, Cherepanova NA, Jurkovska RZ, Jeltsch A, Gromova ES.

BMC Biochem. 2016 Mar 22;17:7. doi: 10.1186/s12858-016-0064-y.


Quality of histone modification antibodies undermines chromatin biology research.

Kungulovski G, Jeltsch A.

Version 2. F1000Res. 2015 Oct 28 [revised 2015 Nov 1];4:1160. doi: 10.12688/f1000research.7265.2. eCollection 2015.


Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates.

Kusevic D, Kudithipudi S, Jeltsch A.

J Biol Chem. 2016 Mar 18;291(12):6124-33. doi: 10.1074/jbc.M115.711952. Epub 2016 Jan 21.


Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase.

Weirich S, Kusevic D, Kudithipudi S, Jeltsch A.

Sci Rep. 2015 Sep 22;5:13813. doi: 10.1038/srep13813.


Editorial: Alfred Pingoud (1945-2015).

Jeltsch A, Wende W, Friedhoff P, Stoddard BL.

Nucleic Acids Res. 2015 Sep 18;43(16):7661-3. doi: 10.1093/nar/gkv846. No abstract available.


Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained.

Kungulovski G, Nunna S, Thomas M, Zanger UM, Reinhardt R, Jeltsch A.

Epigenetics Chromatin. 2015 Mar 18;8:12. doi: 10.1186/s13072-015-0002-z. eCollection 2015.


Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme.

Weirich S, Kudithipudi S, Kycia I, Jeltsch A.

Clin Epigenetics. 2015 Mar 28;7:36. doi: 10.1186/s13148-015-0075-3. eCollection 2015.


Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.

Shanmugam R, Fierer J, Kaiser S, Helm M, Jurkowski TP, Jeltsch A.

Cell Discov. 2015 Jun 9;1:15010. doi: 10.1038/celldisc.2015.10. eCollection 2015.


Specificity analysis of protein lysine methyltransferases using SPOT peptide arrays.

Kudithipudi S, Kusevic D, Weirich S, Jeltsch A.

J Vis Exp. 2014 Nov 29;(93):e52203. doi: 10.3791/52203.


DNMT1-associated DNA methylation changes in cancer.

Bashtrykov P, Jeltsch A.

Cell Cycle. 2015;14(1):5. doi: 10.4161/15384101.2014.989963. No abstract available.


Application of histone modification-specific interaction domains as an alternative to antibodies.

Kungulovski G, Kycia I, Tamas R, Jurkowska RZ, Kudithipudi S, Henry C, Reinhardt R, Labhart P, Jeltsch A.

Genome Res. 2014 Nov;24(11):1842-53. doi: 10.1101/gr.170985.113. Epub 2014 Oct 9.


Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase.

Emperle M, Rajavelu A, Reinhardt R, Jurkowska RZ, Jeltsch A.

J Biol Chem. 2014 Oct 24;289(43):29602-13. doi: 10.1074/jbc.M114.572032. Epub 2014 Aug 21.


The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu.

Shanmugam R, Aklujkar M, Schäfer M, Reinhardt R, Nickel O, Reuter G, Lovley DR, Ehrenhofer-Murray A, Nellen W, Ankri S, Helm M, Jurkowski TP, Jeltsch A.

Nucleic Acids Res. 2014 Jun;42(10):6487-96. doi: 10.1093/nar/gku256. Epub 2014 Apr 7.


Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.

Rilova E, Erdmann A, Gros C, Masson V, Aussagues Y, Poughon-Cassabois V, Rajavelu A, Jeltsch A, Menon Y, Novosad N, Gregoire JM, Vispé S, Schambel P, Ausseil F, Sautel F, Arimondo PB, Cantagrel F.

ChemMedChem. 2014 Mar;9(3):590-601. doi: 10.1002/cmdc.201300420.


Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells.

Nunna S, Reinhardt R, Ragozin S, Jeltsch A.

PLoS One. 2014 Jan 29;9(1):e87703. doi: 10.1371/journal.pone.0087703. eCollection 2014.

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