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Items: 1 to 20 of 188

1.

Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.

Demasi M, Cleland LG, Cook-Johnson RJ, Caughey GE, James MJ.

J Biol Chem. 2017 Sep 22;292(38):15993. doi: 10.1074/jbc.A117.305944. No abstract available.

2.

Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals.

Klauck FJR, James MJ, Glorius F.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12336-12339. doi: 10.1002/anie.201706896. Epub 2017 Aug 29.

PMID:
28762257
3.

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C.

J Med Chem. 2017 Jun 22;60(12):5120-5145. doi: 10.1021/acs.jmedchem.7b00475. Epub 2017 Jun 8.

4.

Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II.

James MJ, Grant ND, O'Brien P, Taylor RJ, Unsworth WP.

Org Lett. 2016 Dec 16;18(24):6256-6259. Epub 2016 Nov 30.

PMID:
27978692
5.

Silica-Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica.

Clarke AK, James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13798-13802. doi: 10.1002/anie.201608263. Epub 2016 Sep 30.

PMID:
27689850
6.

Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor.

James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9671-5. doi: 10.1002/anie.201605337. Epub 2016 Jul 20.

PMID:
27435296
7.

Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones.

Liddon JT, James MJ, Clarke AK, O'Brien P, Taylor RJ, Unsworth WP.

Chemistry. 2016 Jun 20;22(26):8777-80. doi: 10.1002/chem.201601836. Epub 2016 May 19.

8.

Nutritional regulation of long-chain PUFA biosynthetic genes in rainbow trout (Oncorhynchus mykiss).

Gregory MK, Collins RO, Tocher DR, James MJ, Turchini GM.

Br J Nutr. 2016 May 28;115(10):1721-9. doi: 10.1017/S0007114516000830. Epub 2016 Mar 18.

PMID:
26987422
9.

Structure Property Relationships of Carboxylic Acid Isosteres.

Lassalas P, Gay B, Lasfargeas C, James MJ, Tran V, Vijayendran KG, Brunden KR, Kozlowski MC, Thomas CJ, Smith AB 3rd, Huryn DM, Ballatore C.

J Med Chem. 2016 Apr 14;59(7):3183-203. doi: 10.1021/acs.jmedchem.5b01963. Epub 2016 Mar 30.

10.

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.

Saunders EJ, Dadaev T, Leongamornlert DA, Al Olama AA, Benlloch S, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pasayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau SN, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Teixeira MR, Pandha H, Govindasami K, Muir K; UK Genetic Prostate Cancer Study Collaborators; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF, Eeles RA, Kote-Jarai Z.

Br J Cancer. 2016 Apr 12;114(8):945-52.

11.

Synthesis of Spirocyclic Indolenines.

James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Chemistry. 2016 Feb 24;22(9):2856-81. doi: 10.1002/chem.201503835. Epub 2015 Dec 14. Review.

PMID:
26661053
12.

Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles.

James MJ, Clubley RE, Palate KY, Procter TJ, Wyton AC, O'Brien P, Taylor RJ, Unsworth WP.

Org Lett. 2015 Sep 4;17(17):4372-5. doi: 10.1021/acs.orglett.5b02216. Epub 2015 Aug 21.

PMID:
26293968
13.

Plasma n-3 fatty acids and clinical outcomes in recent-onset rheumatoid arthritis.

Proudman SM, Cleland LG, Metcalf RG, Sullivan TR, Spargo LD, James MJ.

Br J Nutr. 2015 Sep 28;114(6):885-90. doi: 10.1017/S0007114515002718. Epub 2015 Aug 18.

PMID:
26283657
14.

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.

Amin Al Olama A, Dadaev T, Hazelett DJ, Li Q, Leongamornlert D, Saunders EJ, Stephens S, Cieza-Borrella C, Whitmore I, Benlloch Garcia S, Giles GG, Southey MC, Fitzgerald L, Gronberg H, Wiklund F, Aly M, Henderson BE, Schumacher F, Haiman CA, Schleutker J, Wahlfors T, Tammela TL, Nordestgaard BG, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Stanford JL, Thibodeau SN, Mcdonnell SK, Schaid DJ, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokołorczyk D, Kluzniak W, Cannon-Albright L, Brenner H, Butterbach K, Arndt V, Park JY, Sellers T, Lin HY, Slavov C, Kaneva R, Mitev V, Batra J, Clements JA, Spurdle A, Teixeira MR, Paulo P, Maia S, Pandha H, Michael A, Kierzek A, Govindasami K, Guy M, Lophatonanon A, Muir K, Viñuela A, Brown AA; PRACTICAL Consortium; COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative; Australian Prostate Cancer BioResource; UK Genetic Prostate Cancer Study Collaborators; UK ProtecT Study Collaborators, Freedman M, Conti DV, Easton D, Coetzee GA, Eeles RA, Kote-Jarai Z.

Hum Mol Genet. 2015 Oct 1;24(19):5589-602. doi: 10.1093/hmg/ddv203. Epub 2015 May 29.

15.

Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds.

James MJ, Cuthbertson JD, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7640-3. doi: 10.1002/anie.201501812. Epub 2015 May 8.

PMID:
25960013
16.

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.

Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB 3rd, Ballatore C, Brunden KR.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4980-2. doi: 10.1016/j.bmcl.2015.03.002. Epub 2015 Mar 14.

17.

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.

Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC.

Nat Commun. 2014 Oct 28;5:5359. doi: 10.1038/ncomms6359.

18.
19.

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.

Cumming JG, Debreczeni JÉ, Edfeldt F, Evertsson E, Harrison M, Holdgate GA, James MJ, Lamont SG, Oldham K, Sullivan JE, Wells SL.

J Med Chem. 2015 Jan 8;58(1):278-93. doi: 10.1021/jm501038s. Epub 2014 Oct 9.

PMID:
25255283
20.

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.

Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C.

ACS Med Chem Lett. 2014 Jul 24;5(9):1015-20. doi: 10.1021/ml5002085. eCollection 2014 Sep 11.

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