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Items: 1 to 20 of 334

1.

PKM2, cancer metabolism, and the road ahead.

Dayton TL, Jacks T, Vander Heiden MG.

EMBO Rep. 2016 Dec;17(12):1721-1730. Review.

PMID:
27856534
2.

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6409-E6417.

3.

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.

4.

A U.S. "Cancer Moonshot" to accelerate cancer research.

Singer DS, Jacks T, Jaffee E.

Science. 2016 Sep 9;353(6304):1105-6. doi: 10.1126/science.aai7862. No abstract available.

PMID:
27605537
5.

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.

Muzumdar MD, Dorans KJ, Chung KM, Robbins R, Tammela T, Gocheva V, Li CM, Jacks T.

Nat Commun. 2016 Sep 2;7:12685. doi: 10.1038/ncomms12685.

6.

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.

Cell Metab. 2016 Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001.

PMID:
27476975
7.

BIOMEDICAL ENGINEERING. Capitalizing on convergence for health care.

Sharp P, Jacks T, Hockfield S.

Science. 2016 Jun 24;352(6293):1522-3. doi: 10.1126/science.aag2350. No abstract available.

PMID:
27339972
8.

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.

Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.

Cell. 2016 May 5;165(4):896-909. doi: 10.1016/j.cell.2016.04.039.

PMID:
27153497
9.

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG.

Genes Dev. 2016 May 1;30(9):1020-33. doi: 10.1101/gad.278549.116.

10.

A Modular Assembly Platform for Rapid Generation of DNA Constructs.

Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout WM 3rd, Papagiannakopoulos T, Xue W, Jacks T.

Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836.

11.

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG.

Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007.

12.

Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development.

Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, Bendor J, Jacks T.

Cancer Discov. 2016 Feb;6(2):188-201. doi: 10.1158/2159-8290.CD-15-0854.

13.

Recombinase-based conditional and reversible gene regulation via XTR alleles.

Robles-Oteiza C, Taylor S, Yates T, Cicchini M, Lauderback B, Cashman CR, Burds AA, Winslow MM, Jacks T, Feldser DM.

Nat Commun. 2015 Nov 5;6:8783. doi: 10.1038/ncomms9783.

14.

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT.

Nat Med. 2015 Oct;21(10):1163-71. doi: 10.1038/nm.3952.

15.

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T.

Genes Dev. 2015 Sep 1;29(17):1850-62. doi: 10.1101/gad.267393.115.

16.

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

Joshi NS, Akama-Garren EH, Lu Y, Lee DY, Chang GP, Li A, DuPage M, Tammela T, Kerper NR, Farago AF, Robbins R, Crowley DM, Bronson RT, Jacks T.

Immunity. 2015 Sep 15;43(3):579-90. doi: 10.1016/j.immuni.2015.08.006.

17.

Applications of the CRISPR-Cas9 system in cancer biology.

Sánchez-Rivera FJ, Jacks T.

Nat Rev Cancer. 2015 Jul;15(7):387-95. doi: 10.1038/nrc3950. Review.

18.

A versatile reporter system for CRISPR-mediated chromosomal rearrangements.

Li Y, Park AI, Mou H, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z, Xue W.

Genome Biol. 2015 May 28;16:111. doi: 10.1186/s13059-015-0680-7.

19.

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.

Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG.

Nano Lett. 2015 May 13;15(5):3008-16. doi: 10.1021/nl5048972.

20.

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM 3rd, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, Patel NU, March RJ, Tam AT, Milano RJ, Boisvert JL, Hicks MA, Elmiligy S, Malstrom SE, Rivera MN, Harada H, Windle BE, Ramaswamy S, Benes CH, Jacks T, Engelman JA.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1288-96. doi: 10.1073/pnas.1411848112.

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