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Items: 1 to 20 of 121

1.

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.

Zadora J, Singh M, Herse F, Przybyl L, Haase N, Golic M, Yung HW, Huppertz B, Cartwright JE, Whitley GS, Johnsen GM, Levi G, Isbruch A, Schulz H, Luft FC, Müller DN, Staff AC, Hurst LD, Dechend R, Izsvák Z.

Circulation. 2017 Sep 13. pii: CIRCULATIONAHA.117.028110. doi: 10.1161/CIRCULATIONAHA.117.028110. [Epub ahead of print]

PMID:
28904069
2.

Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System.

Hodge R, Narayanavari S, Izsvák Z, Ivics Z.

Hum Gene Ther. 2017 Sep 4. doi: 10.1089/hum.2017.130. [Epub ahead of print]

PMID:
28870121
3.

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.

Römer C, Singh M, Hurst LD, Izsvák Z.

Curr Opin Virol. 2017 Jul 24;25:49-58. doi: 10.1016/j.coviro.2017.07.001. [Epub ahead of print] Review.

PMID:
28750248
4.

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.

Hudecek M, Izsvák Z, Johnen S, Renner M, Thumann G, Ivics Z.

Crit Rev Biochem Mol Biol. 2017 Aug;52(4):355-380. doi: 10.1080/10409238.2017.1304354. Epub 2017 Apr 12. Review.

PMID:
28402189
5.

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Liška F, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Strnad H, Trnovská J, Škop V, Kazdová L, Starker CG, Voytas DF, Izsvák Z, Mancini M, Šeda O, Křen V, Pravenec M.

Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.

PMID:
28396530
6.

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids.

Thumann G, Harmening N, Prat-Souteyrand C, Marie C, Pastor M, Sebe A, Miskey C, Hurst LD, Diarra S, Kropp M, Walter P, Scherman D, Ivics Z, Izsvák Z, Johnen S.

Mol Ther Nucleic Acids. 2017 Mar 17;6:302-314. doi: 10.1016/j.omtn.2017.02.002. Epub 2017 Feb 10.

7.

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy.

Verhenne S, Vandeputte N, Pareyn I, Izsvák Z, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):836-844. doi: 10.1161/ATVBAHA.116.308680. Epub 2017 Mar 2.

PMID:
28254814
8.

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.

Zhou MB, Hu H, Miskey C, Lazarow K, Ivics Z, Kunze R, Yang G, Izsvák Z, Tang DQ.

Mol Phylogenet Evol. 2017 Apr;109:367-374. doi: 10.1016/j.ympev.2017.02.005. Epub 2017 Feb 9.

PMID:
28189615
9.

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.

Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.

PMID:
28132834
10.

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

Wang Y, Pryputniewicz-Dobrinska D, Nagy EÉ, Kaufman CD, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvák Z.

Nucleic Acids Res. 2017 Jan 9;45(1):311-326. doi: 10.1093/nar/gkw1164. Epub 2016 Dec 1.

11.

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.

12.

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

Liška F, Peterková R, Peterka M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Křen V, Starker CG, Voytas DF, Izsvák Z, Pravenec M.

PLoS One. 2016 Oct 11;11(10):e0164206. doi: 10.1371/journal.pone.0164206. eCollection 2016.

13.

Sleeping Beauty transposition: from biology to applications.

Narayanavari SA, Chilkunda SS, Ivics Z, Izsvák Z.

Crit Rev Biochem Mol Biol. 2017 Feb;52(1):18-44. doi: 10.1080/10409238.2016.1237935. Epub 2016 Oct 4. Review.

PMID:
27696897
14.

Structural Determinants of Sleeping Beauty Transposase Activity.

Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z.

Mol Ther. 2016 Aug;24(8):1369-77. doi: 10.1038/mt.2016.110. Epub 2016 Jun 6.

15.

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

Fatima A, Ivanyuk D, Herms S, Heilmann-Heimbach S, O'Shea O, Chapman C, Izsvák Z, Farr M, Hescheler J, Šarić T.

Stem Cell Res. 2016 Mar;16(2):304-7. doi: 10.1016/j.scr.2015.12.039. Epub 2016 Jan 6.

16.

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mátés L, Izsvák Z, Ivics Z, Barabas O.

Nat Commun. 2016 Mar 30;7:11126. doi: 10.1038/ncomms11126.

17.

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.

Grabundzija I, Messing SA, Thomas J, Cosby RL, Bilic I, Miskey C, Gogol-Döring A, Kapitonov V, Diem T, Dalda A, Jurka J, Pritham EJ, Dyda F, Izsvák Z, Ivics Z.

Nat Commun. 2016 Mar 2;7:10716. doi: 10.1038/ncomms10716.

18.

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z.

Nat Protoc. 2016 Feb;11(2):327-46. doi: 10.1038/nprot.2016.016. Epub 2016 Jan 21.

PMID:
26797457
19.

Full-length Dysferlin Transfer by the Hyperactive Sleeping Beauty Transposase Restores Dysferlin-deficient Muscle.

Escobar H, Schöwel V, Spuler S, Marg A, Izsvák Z.

Mol Ther Nucleic Acids. 2016 Jan 19;5:e277. doi: 10.1038/mtna.2015.52.

20.

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z.

Mol Ther. 2016 Mar;24(3):592-606. doi: 10.1038/mt.2016.11. Epub 2016 Jan 12.

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