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Items: 1 to 20 of 155


Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.

Poon KL, Wang X, Ng AS, Goh WH, McGinnis C, Fowler S, Carney TJ, Wang H, Ingham PW.

Arch Toxicol. 2016 Aug 2.


An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.

Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW.

EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532.


Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.

Robertson AL, Ogryzko NV, Henry KM, Loynes CA, Foulkes MJ, Meloni MM, Wang X, Ford C, Jackson M, Ingham PW, Wilson HL, Farrow SN, Solari R, Flower RJ, Jones S, Whyte MK, Renshaw SA.

Dis Model Mech. 2016 Jun 1;9(6):621-32. doi: 10.1242/dmm.024935.


Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes.

Ingham PW.

Curr Top Dev Biol. 2016;116:477-88. doi: 10.1016/bs.ctdb.2016.01.007.


The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.

Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stünkel W.

Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573.


Hedgehog signalling.

Lee RT, Zhao Z, Ingham PW.

Development. 2016 Feb 1;143(3):367-72. doi: 10.1242/dev.120154. Review.


Deep sequencing of small RNA facilitates tissue and sex associated microRNA discovery in zebrafish.

Vaz C, Wee CW, Lee GP, Ingham PW, Tanavde V, Mathavan S.

BMC Genomics. 2015 Nov 16;16:950. doi: 10.1186/s12864-015-2135-7.


Adaxial cell migration in the zebrafish embryo is an active cell autonomous property that requires the Prdm1a transcription factor.

Ono Y, Yu W, Jackson HE, Parkin CA, Ingham PW.

Differentiation. 2015 Mar-Apr;89(3-4):77-86. doi: 10.1016/j.diff.2015.03.002.


The role of Sox6 in zebrafish muscle fiber type specification.

Jackson HE, Ono Y, Wang X, Elworthy S, Cunliffe VT, Ingham PW.

Skelet Muscle. 2015 Jan 27;5(1):2. doi: 10.1186/s13395-014-0026-2.


On the origin of SCPP genes.

Venkatesh B, Lee AP, Ravi V, Maurya AK, Korzh V, Lim ZW, Ingham PW, Boehm T, Brenner S, Warren WC.

Evol Dev. 2014 May;16(3):125-6. doi: 10.1111/ede.12072. No abstract available.


Divergence of zebrafish and mouse lymphatic cell fate specification pathways.

van Impel A, Zhao Z, Hermkens DM, Roukens MG, Fischer JC, Peterson-Maduro J, Duckers H, Ober EA, Ingham PW, Schulte-Merker S.

Development. 2014 Mar;141(6):1228-38. doi: 10.1242/dev.105031.


Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MK, Renshaw SA.

J Immunol. 2014 Feb 15;192(4):1796-805. doi: 10.4049/jimmunol.1300087.


Elephant shark genome provides unique insights into gnathostome evolution.

Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A, Hillier LW, Minx P, Boehm T, Wilson RK, Brenner S, Warren WC.

Nature. 2014 Jan 9;505(7482):174-9. doi: 10.1038/nature12826. Erratum in: Nature. 2014 Sep 25;513(7519):574.


A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies.

Wilkinson RN, Elworthy S, Ingham PW, van Eeden FJ.

Biotechniques. 2013 Dec;55(6):314-6. doi: 10.2144/000114116.


Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.

Maurya AK, Ben J, Zhao Z, Lee RT, Niah W, Ng AS, Iyu A, Yu W, Elworthy S, van Eeden FJ, Ingham PW.

PLoS Genet. 2013;9(12):e1003955. doi: 10.1371/journal.pgen.1003955.


Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library.

Wang X, Robertson AL, Li J, Chai RJ, Haishan W, Sadiku P, Ogryzko NV, Everett M, Yoganathan K, Luo HR, Renshaw SA, Ingham PW.

Dis Model Mech. 2014 Jan;7(1):163-9. doi: 10.1242/dmm.012047.


Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.

Wang X, Zhao Z, Muller J, Iyu A, Khng AJ, Guccione E, Ruan Y, Ingham PW.

Biol Open. 2013 Sep 9;2(11):1203-13. doi: 10.1242/bio.20136262.


Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.

Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R.

Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340.


TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R, Allen CE, Heath PR, Milo M, Muqit MM, Reichert AS, Köster RW, Ingham PW, Bandmann O.

Ann Neurol. 2013 Dec;74(6):837-47. doi: 10.1002/ana.23999.


Control of muscle fibre-type diversity during embryonic development: the zebrafish paradigm.

Jackson HE, Ingham PW.

Mech Dev. 2013 Sep-Oct;130(9-10):447-57. doi: 10.1016/j.mod.2013.06.001. Review.

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