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East Mediterr Health J. 2010 Aug;16(8):893-900.

Immunoinflammatory markers and disease activity in systemic lupus erythematosus: something old, something new.

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Department of Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt.


This study assessed the utility of some novel inflammatory markers compared with traditional laboratory markers in patients with systemic lupus erythematosus (SLE). In a cohort of 43 SLE patients (19 with inactive and 24 with active SLE) and 20 healthy controls, serial measures of soluble vascular cell adhesion molecule (sVCAM-1) were significantly associated with SLE disease activity, scored using the British Isles Lupus Assessment Group index. Inflammatory markers neopterin and soluble intercellular adhesion molecule (sICAM-1) appeared to be clinically useful for isolated assessments of disease activity. Both antibodies to double-stranded DNA (anti-dsDNA) and sVCAM-1 were relatively good markers of disease activity and could help to predict remission or monitorthe therapeutic response in SLE.

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