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Items: 1 to 20 of 48

1.

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.

Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE.

Geroscience. 2017 Apr;39(2):129-145. doi: 10.1007/s11357-017-9971-0. Epub 2017 Apr 13.

2.

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence.

Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A.

Redox Biol. 2017 Apr;11:30-37. doi: 10.1016/j.redox.2016.10.014. Epub 2016 Nov 2.

3.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.

4.

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.

Zhang Y, Liu Y, Walsh M, Bokov A, Ikeno Y, Jang YC, Perez VI, Van Remmen H, Richardson A.

Mech Ageing Dev. 2016 Mar;154:1-8. doi: 10.1016/j.mad.2016.01.005. Epub 2016 Feb 1.

5.

The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.

Treuting PM, Snyder JM, Ikeno Y, Schofield PN, Ward JM, Sundberg JP.

Vet Pathol. 2016 Mar;53(2):244-9. doi: 10.1177/0300985815620629. Epub 2016 Jan 20.

6.

Significant life extension by ten percent dietary restriction.

Richardson A, Austad SN, Ikeno Y, Unnikrishnan A, McCarter RJ.

Ann N Y Acad Sci. 2016 Jan;1363:11-7. doi: 10.1111/nyas.12982. Epub 2015 Dec 22.

7.

Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Ghosh Choudhury G, Hubbard GB, Barnes JL, Richardson A, Kasinath BS.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):850-7. doi: 10.1093/gerona/glv170. Epub 2015 Oct 5.

8.

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22.

9.

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.

Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE.

J Bone Miner Res. 2016 Feb;31(2):443-54. doi: 10.1002/jbmr.2689. Epub 2015 Sep 3.

10.

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe RA, Ciol MA, Ritchey J, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):431-4. doi: 10.1093/gerona/glv079. Epub 2015 Aug 4.

11.

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.

Aging (Albany NY). 2015 Jul;7(7):500-12.

12.

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.

13.

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.

Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.

14.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.

15.

Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I.

Salmon AB, Lerner C, Ikeno Y, Motch Perrine SM, McCarter R, Sell C.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E545-53. doi: 10.1152/ajpendo.00558.2014. Epub 2015 Feb 3.

16.

Reduced expression of MYC increases longevity and enhances healthspan.

Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM.

Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.

17.

Teneligliptin as an initial therapy for newly diagnosed, drug naive subjects with type 2 diabetes.

Kutoh E, Hirate M, Ikeno Y.

J Clin Med Res. 2014 Aug;6(4):287-94. doi: 10.14740/jocmr1841e. Epub 2014 May 22.

18.

Reductions in serum IGF-1 during aging impair health span.

Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S.

Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30.

19.

Pathology is a critical aspect of preclinical aging studies.

Ladiges W, Ikeno Y, Liggitt D, Treuting PM.

Pathobiol Aging Age Relat Dis. 2013 Aug 20;3. doi: 10.3402/pba.v3i0.22451. eCollection 2013.

20.

Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.

Lorenzini A, Salmon AB, Lerner C, Torres C, Ikeno Y, Motch S, McCarter R, Sell C.

J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):410-9. doi: 10.1093/gerona/glt108. Epub 2013 Jul 20.

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