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Items: 1 to 20 of 549


Identification of α-Mangostin as A Potent Agonist of Human STING.

Zhang Y, Sun Z, Pei J, Luo Q, Zeng X, Li Q, Yang Z, Quan J.

ChemMedChem. 2018 Aug 6. doi: 10.1002/cmdc.201800481. [Epub ahead of print]


Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages.

Han HS, Shin JS, Lee SB, Park JC, Lee KT.

Chem Biol Interact. 2018 Jul 25;293:38-47. doi: 10.1016/j.cbi.2018.07.024. [Epub ahead of print]


Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

Lin SH, Chuang HY, Ho JC, Lee CH, Hsiao CC.

J Dermatol Sci. 2018 May 29. pii: S0923-1811(18)30235-4. doi: 10.1016/j.jdermsci.2018.05.009. [Epub ahead of print]


Leishmania donovani Exploits Tollip, a Multitasking Protein, To Impair TLR/IL-1R Signaling for Its Survival in the Host.

Parmar N, Chandrakar P, Vishwakarma P, Singh K, Mitra K, Kar S.

J Immunol. 2018 Aug 1;201(3):957-970. doi: 10.4049/jimmunol.1800062. Epub 2018 Jun 15.


Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.

Hsu AT, Lupancu TJ, Lee MC, Fleetwood AJ, Cook AD, Hamilton JA, Achuthan A.

J Biol Chem. 2018 Jul 20;293(29):11415-11423. doi: 10.1074/jbc.RA118.002416. Epub 2018 Jun 5.


Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1.

Aziz N, Son YJ, Cho JY.

Int J Mol Sci. 2018 May 3;19(5). pii: E1355. doi: 10.3390/ijms19051355.


InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity.

Yang L, Gu W, Cheung KH, Yan L, Tong BC, Jiang Y, Yang J.

BMC Biol. 2018 Apr 27;16(1):46. doi: 10.1186/s12915-018-0507-6.


Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Huang C, Lewis C, Borg NA, Canals M, Diep H, Drummond GR, Goode RJ, Schittenhelm RB, Vinh A, Zhu M, Kemp-Harper B, Kleifeld O, Stone MJ.

J Proteome Res. 2018 Apr 6;17(4):1485-1499. doi: 10.1021/acs.jproteome.7b00828. Epub 2018 Mar 13.


p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.

Yi YS, Jian J, Gonzalez-Gugel E, Shi YX, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu CJ.

EBioMedicine. 2018 Mar;29:78-91. doi: 10.1016/j.ebiom.2018.02.012. Epub 2018 Feb 16.


Differences in TLR7/8 activation between monocytes and macrophages.

Eng HL, Hsu YY, Lin TM.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):319-325. doi: 10.1016/j.bbrc.2018.02.079. Epub 2018 Feb 12.


Recombinant Mtb9.8 of Mycobacterium bovis stimulates TNF-α and IL-1β secretion by RAW264.7 macrophages through activation of NF-κB pathway via TLR2.

Liu S, Jia H, Hou S, Xin T, Guo X, Zhang G, Gao X, Li M, Zhu W, Zhu H.

Sci Rep. 2018 Jan 31;8(1):1928. doi: 10.1038/s41598-018-20433-x.


Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis.

Dong J, Ma Q.

Nanotoxicology. 2018 Mar;12(2):153-168. doi: 10.1080/17435390.2018.1425501. Epub 2018 Jan 16.


IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation.

Kawaguchi M, Oka T, Sugaya M, Suga H, Kimura T, Morimura S, Fujita H, Sato S.

J Dermatol Sci. 2018 Apr;90(1):35-45. doi: 10.1016/j.jdermsci.2017.12.014. Epub 2017 Dec 28.


Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB.

Blood Adv. 2017 Jun 7;1(14):947-960. doi: 10.1182/bloodadvances.2017006858. eCollection 2017 Jun 13.


A poly(beta-amino ester) activates macrophages independent of NF-κB signaling.

Dold NM, Zeng Q, Zeng X, Jewell CM.

Acta Biomater. 2018 Mar 1;68:168-177. doi: 10.1016/j.actbio.2017.12.040. Epub 2017 Dec 30.


Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages.

Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kühnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N.

Stem Cell Reports. 2018 Jan 9;10(1):7-16. doi: 10.1016/j.stemcr.2017.11.011. Epub 2017 Dec 14.


FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.

Park MY, Kim HS, Lee M, Park B, Lee HY, Cho EB, Seong JY, Bae YS.

Sci Rep. 2017 Nov 14;7(1):15575. doi: 10.1038/s41598-017-15586-0.


An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses.

Carlin AF, Plummer EM, Vizcarra EA, Sheets N, Joo Y, Tang W, Day J, Greenbaum J, Glass CK, Diamond MS, Shresta S.

Cell Rep. 2017 Nov 7;21(6):1600-1612. doi: 10.1016/j.celrep.2017.10.054.


The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2.

Chistiakov DA, Myasoedova VA, Revin VV, Orekhov AN, Bobryshev YV.

Immunobiology. 2018 Jan;223(1):101-111. doi: 10.1016/j.imbio.2017.10.005. Epub 2017 Oct 5. Review.


IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.

Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM.

PLoS Pathog. 2017 Oct 2;13(10):e1006647. doi: 10.1371/journal.ppat.1006647. eCollection 2017 Oct.

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