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  • Showing results for IL-1[Title] AND IL-23[Title] AND mediate[Title] AND early[Title] AND IL-17A[Title] AND production[Title] AND inflammation[Title] AND leading[Title] AND late[Title] AND fibrosis[Title]. Your search for IL-1 and IL-23 mediate early IL-17A production inpulmonary inflammation leading to late fibrosis retrieved no results.
PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

Author information

1
University of Orleans and CNRS, UMR6218, Orleans, France.

Abstract

BACKGROUND:

Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated recently the predominant role of the NLRP3 inflammasome activation and IL-1β expression in the establishment of pulmonary inflammation and fibrosis in mice.

METHODS:

The contribution of IL-23 or IL-17 in pulmonary inflammation and fibrosis was assessed using the bleomycin model in deficient mice.

RESULTS:

We show that bleomycin or IL-1β-induced lung injury leads to increased expression of early IL-23p19, and IL-17A or IL-17F expression. Early IL-23p19 and IL-17A, but not IL-17F, and IL-17RA signaling are required for inflammatory response to BLM as shown with gene deficient mice or mice treated with neutralizing antibodies. Using FACS analysis, we show a very early IL-17A and IL-17F expression by RORγt(+) γδ T cells and to a lesser extent by CD4αβ(+) T cells, but not by iNKT cells, 24 hrs after BLM administration. Moreover, IL-23p19 and IL-17A expressions or IL-17RA signaling are necessary to pulmonary TGF-β1 production, collagen deposition and evolution to fibrosis.

CONCLUSIONS:

Our findings demonstrate the existence of an early IL-1β-IL-23-IL-17A axis leading to pulmonary inflammation and fibrosis and identify innate IL-23 and IL-17A as interesting drug targets for IL-1β driven lung pathology.

PMID:
21858022
PMCID:
PMC3156735
DOI:
10.1371/journal.pone.0023185
[Indexed for MEDLINE]
Free PMC Article

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