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IGF-1 axis changes with ADT and docetaxel in metastatic prostate cancer.
Ravi P, Wang V, Fichorova RN, McGregor B, Wei XX, Basaria S, Sweeney CJ. Ravi P, et al. Endocr Relat Cancer. 2023 Oct 4;30(11):e230241. doi: 10.1530/ERC-23-0241. Print 2023 Nov 1. Endocr Relat Cancer. 2023. PMID: 37671811

At 6 months, significant increases in IGF-BP1 (mean delta+27.4%, P = 0.033), IGF-BP3 (mean delta+10.3%, P < 0.001), and IGF-BP4 (mean delta+31.1%, P < 0.001) were seen in the ADT + D group, while the ADT group showed an increase in IGF-BP3 (mean delta+5.5%, P

…

At 6 months, significant increases in IGF-BP1 (mean delta+27.4%, P = 0.033), IGF-BP3 (mean delta+10.3%, P < 0.001), and IGF-BP4

…
Signaling by insulin-like growth factors in paralyzed skeletal muscle: rapid induction of IGF1 expression in muscle fibers and prevention of interstitial cell proliferation by IGF-BP5 and IGF-BP4.
Caroni P, Schneider C. Caroni P, et al. J Neurosci. 1994 May;14(5 Pt 2):3378-88. doi: 10.1523/JNEUROSCI.14-05-03378.1994. J Neurosci. 1994. PMID: 7514217 Free PMC article.
To determine whether IGFs may participate in the initiation of restorative reactions in inactivated muscle we analyzed the expression of IGF1 and IGF2 mRNA in botulinum toxin-paralyzed and in denervated rat skeletal muscle, and interfered with the activity of IGFs by locally appl …
To determine whether IGFs may participate in the initiation of restorative reactions in inactivated muscle we analyzed the expression of IGF …
Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4.
Caroni P, Schneider C, Kiefer MC, Zapf J. Caroni P, et al. J Cell Biol. 1994 May;125(4):893-902. doi: 10.1083/jcb.125.4.893. J Cell Biol. 1994. PMID: 7514606 Free PMC article.
In this study we have exploited the high affinity and specificity of IGF-binding protein 4 (IGF-BP4) and IGF-BP5 for IGF1 and IGF2 to determine whether these growth factors are involved in the nerve sprouting reaction in paralyzed skeletal muscle. ...In in vivo expe …
In this study we have exploited the high affinity and specificity of IGF-binding protein 4 (IGF-BP4) and IGF-BP5 for IGF1 and …
Modulation of the insulin-like growth factor-I system by N-(4-hydroxyphenyl)-retinamide in human breast cancer cell lines.
Favoni RE, de Cupis A, Bruno S, Yee D, Ferrera A, Pirani P, Costa A, Decensi A. Favoni RE, et al. Br J Cancer. 1998 Jun;77(12):2138-47. doi: 10.1038/bjc.1998.358. Br J Cancer. 1998. PMID: 9649125 Free PMC article.
Western ligand blot analysis showed a reduction of IGF-binding protein 4 (BP4) and BP5 by 67% and 87%, respectively, in MCF-7, whereas IGF-BP4 and -BP1 were reduced by approximately 20% in MDA-MB231 cells. ...
Western ligand blot analysis showed a reduction of IGF-binding protein 4 (BP4) and BP5 by 67% and 87%, respectively, in MCF-7, whereas IG …
Possible autocrine/paracrine actions of insulin-like growth factors during embryonic development: expression and action of IGFs in undifferentiated P19 cells.
Eicher DJ, Moats-Staats BM, Stiles AD, D'Ercole AJ. Eicher DJ, et al. Dev Genet. 1993;14(3):194-203. doi: 10.1002/dvg.1020140306. Dev Genet. 1993. PMID: 8358865
Undifferentiated P19 cells synthesized IGF I and II, the type I and II IGF receptors, and IGF binding proteins (IGF BP2, IGF BP3, and IGF BP4). P19 cells showed an increase in thymidine incorporation of 150% of control with a 4 hour incubation of IGF I (10 ng/ml) or …
Undifferentiated P19 cells synthesized IGF I and II, the type I and II IGF receptors, and IGF binding proteins (IGF BP2, IGF BP3, and IGF …