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Items: 1 to 20 of 55

1.

Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome.

Mavrangelos C, Campaniello MA, Andrews JM, Bampton PA, Hughes PA.

Gut. 2017 Jun 10. pii: gutjnl-2017-314308. doi: 10.1136/gutjnl-2017-314308. [Epub ahead of print] No abstract available.

PMID:
28601848
2.

Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.

Campaniello MA, Mavrangelos C, Eade S, Harrington AM, Blackshaw LA, Brierley SM, Smid SD, Hughes PA.

Brain Behav Immun. 2017 Feb;60:319-332. doi: 10.1016/j.bbi.2016.11.015. Epub 2016 Nov 15.

PMID:
27864046
3.

Fluoxetine for Maintenance of Remission and to Improve Quality of Life in Patients with Crohn's Disease: a Pilot Randomized Placebo-Controlled Trial.

Mikocka-Walus A, Hughes PA, Bampton P, Gordon A, Campaniello MA, Mavrangelos C, Stewart BJ, Esterman A, Andrews JM.

J Crohns Colitis. 2017 Apr 1;11(4):509-514. doi: 10.1093/ecco-jcc/jjw165.

PMID:
27664274
4.

Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications.

Hughes PA, Costello SP, Bryant RV, Andrews JM.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G501-13. doi: 10.1152/ajpgi.00442.2015. Epub 2016 Jul 28. Review.

PMID:
27469369
5.

Sleeping in on pancreatic cancer pain: Schwann cell secreted IL-6 pushes snooze on the pain alarm.

Hughes PA.

Gut. 2016 Jun;65(6):897-8. doi: 10.1136/gutjnl-2015-311272. Epub 2016 Feb 10. No abstract available.

PMID:
26864073
6.

Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity.

Campaniello MA, Harrington AM, Martin CM, Ashley Blackshaw L, Brierley SM, Hughes PA.

Neurogastroenterol Motil. 2016 Jan;28(1):54-63. doi: 10.1111/nmo.12696. Epub 2015 Oct 14.

PMID:
26468044
7.

Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients.

Hughes PA, Moretta M, Lim A, Grasby DJ, Bird D, Brierley SM, Liebregts T, Adam B, Blackshaw LA, Holtmann G, Bampton P, Hoffmann P, Andrews JM, Zola H, Krumbiegel D.

Brain Behav Immun. 2014 Nov;42:191-203. doi: 10.1016/j.bbi.2014.07.001. Epub 2014 Jul 23.

PMID:
25063707
8.

Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression.

Malsch P, Andratsch M, Vogl C, Link AS, Alzheimer C, Brierley SM, Hughes PA, Kress M.

J Neurosci. 2014 Jul 23;34(30):9845-56. doi: 10.1523/JNEUROSCI.5161-13.2014.

9.

Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity.

Hughes PA, Castro J, Harrington AM, Isaacs N, Moretta M, Hicks GA, Urso DM, Brierley SM.

Gut. 2014 Jul;63(7):1199-200. doi: 10.1136/gutjnl-2013-306240. Epub 2013 Nov 27. No abstract available.

PMID:
24285775
10.

Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.

Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM.

Gastroenterology. 2013 Dec;145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. Epub 2013 Aug 16.

11.

Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?

Hughes PA, Zola H, Penttila IA, Blackshaw LA, Andrews JM, Krumbiegel D.

Am J Gastroenterol. 2013 Jul;108(7):1066-74. doi: 10.1038/ajg.2013.120. Epub 2013 May 7. Review.

PMID:
23649183
12.
13.

Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes.

Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw LA, Brierley SM.

Gut. 2013 Oct;62(10):1456-65. doi: 10.1136/gutjnl-2011-301856. Epub 2012 Jul 5.

PMID:
22767422
14.

Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity.

Harrington AM, Brierley SM, Isaacs N, Hughes PA, Castro J, Blackshaw LA.

J Comp Neurol. 2012 Jul 1;520(10):2241-55. doi: 10.1002/cne.23042.

PMID:
22237807
15.

Comprehensive care of adults with acute ischemic stroke.

Hughes PA.

Crit Care Nurs Clin North Am. 2011 Dec;23(4):661-75. doi: 10.1016/j.ccell.2011.08.009. Review.

PMID:
22118121
16.

The hot mustard receptor's role in gut motor function.

Blackshaw LA, Brierley SM, Hughes PA, Harrington AM.

Gastroenterology. 2011 Aug;141(2):423-7. doi: 10.1053/j.gastro.2011.06.028. Epub 2011 Jun 22. No abstract available.

PMID:
21703264
17.

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity.

Brierley SM, Castro J, Harrington AM, Hughes PA, Page AJ, Rychkov GY, Blackshaw LA.

J Physiol. 2011 Jul 15;589(Pt 14):3575-93. doi: 10.1113/jphysiol.2011.206789. Epub 2011 May 9.

18.

A novel role for TRPM8 in visceral afferent function.

Harrington AM, Hughes PA, Martin CM, Yang J, Castro J, Isaacs NJ, Blackshaw LA, Brierley SM.

Pain. 2011 Jul;152(7):1459-68. doi: 10.1016/j.pain.2011.01.027. Epub 2011 Apr 13.

PMID:
21489690
19.

Medication adherence in children and adolescents with HIV infection: associations with behavioral impairment.

Malee K, Williams P, Montepiedra G, McCabe M, Nichols S, Sirois PA, Storm D, Farley J, Kammerer B; PACTG 219C Team.

AIDS Patient Care STDS. 2011 Mar;25(3):191-200. doi: 10.1089/apc.2010.0181. Epub 2011 Feb 16.

20.

Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain.

Brierley SM, Hughes PA, Harrington AM, Rychkov GY, Blackshaw LA.

Pharmaceuticals (Basel). 2010 Aug 26;3(9):2768-2798. Review.

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