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Am J Perinatol. 2014 Oct;31(9):811-21. doi: 10.1055/s-0033-1361933. Epub 2013 Dec 17.

Medication use in the neonatal intensive care unit.

Author information

1
Duke-National University of Singapore Graduate Medical School, Singapore.
2
Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina.
3
Pediatrix-Obstetrix Center for Research and Education, Sunrise, Florida.
4
Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina.

Abstract

OBJECTIVE:

The aim of the article is to provide an update on medication use in infants admitted to the neonatal intensive care unit (NICU) in the United States and examine how use has changed over time.

STUDY DESIGN:

We performed a retrospective review (2005-2010) of a large prospectively collected administrative database.

RESULT:

Medications most commonly administered during the study period were ampicillin, gentamicin, caffeine citrate, vancomycin, beractant, furosemide, fentanyl, dopamine, midazolam, and calfactant (56-681 exposures per 1,000 infants). Those with the greatest relative increase in use included azithromycin, sildenafil, and milrinone. Medications with the greatest relative decrease in use included theophylline, metoclopramide, and doxapram.

CONCLUSION:

Medication use in the NICU has changed substantially over time, and only 35% of the most commonly prescribed medications are Food and Drug Administration -approved in infants.

PMID:
24347262
PMCID:
PMC4061287
DOI:
10.1055/s-0033-1361933
[Indexed for MEDLINE]
Free PMC Article

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