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Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.

Trevelin SC, Dos Santos CX, Ferreira RG, de Sá Lima L, Silva RL, Scavone C, Curi R, Alves-Filho JC, Cunha TM, Roxo-Júnior P, Cervi MC, Laurindo FR, Hothersall JS, Cobb AM, Zhang M, Ivetic A, Shah AM, Lopes LR, Cunha FQ.

Sci Rep. 2016 Oct 4;6:34581. doi: 10.1038/srep34581.


Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

Hothersall JD, Brown AJ, Dale I, Rawlins P.

Drug Discov Today. 2016 Jan;21(1):90-6. doi: 10.1016/j.drudis.2015.07.015. Review.


Sustained wash-resistant receptor activation responses of GPR119 agonists.

Hothersall JD, Bussey CE, Brown AJ, Scott JS, Dale I, Rawlins P.

Eur J Pharmacol. 2015 Sep 5;762:430-42. doi: 10.1016/j.ejphar.2015.06.031.


5-Hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to its subsequent release.

Hothersall JD, Alexander A, Samson AJ, Moffat C, Bollan KA, Connolly CN.

J Biol Chem. 2014 Nov 14;289(46):32020-9. doi: 10.1074/jbc.M114.594796.


Biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586 involves parallel pathways.

Gao SS, Hothersall J, Wu J, Murphy AC, Song Z, Stephens ER, Thomas CM, Crump MP, Cox RJ, Simpson TJ, Willis CL.

J Am Chem Soc. 2014 Apr 9;136(14):5501-7. doi: 10.1021/ja501731p.


A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis.

Haines AS, Dong X, Song Z, Farmer R, Williams C, Hothersall J, Płoskoń E, Wattana-amorn P, Stephens ER, Yamada E, Gurney R, Takebayashi Y, Masschelein J, Cox RJ, Lavigne R, Willis CL, Simpson TJ, Crosby J, Winn PJ, Thomas CM, Crump MP.

Nat Chem Biol. 2013 Nov;9(11):685-92. doi: 10.1038/nchembio.1342.


Metabolic fate of the increased yeast amino Acid uptake subsequent to catabolite derepression.

Hothersall JS, Ahmed A.

J Amino Acids. 2013;2013:461901. doi: 10.1155/2013/461901.


The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland.

Bollan KA, Hothersall JD, Moffat C, Durkacz J, Saranzewa N, Wright GA, Raine NE, Highet F, Connolly CN.

Parasitol Res. 2013 Feb;112(2):751-9. doi: 10.1007/s00436-012-3195-0.


Tamoxifen subcellular localization; observation of cell-specific cytotoxicity enhancement by inhibition of mitochondrial ETC complexes I and III.

Theodossiou TA, Yannakopoulou K, Aggelidou C, Hothersall JS.

Photochem Photobiol. 2012 Jul-Aug;88(4):1016-22. doi: 10.1111/j.1751-1097.2012.01144.x.


High-affinity fluorescent ligands for the 5-HT(3) receptor.

Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner M.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1151-5. doi: 10.1016/j.bmcl.2011.11.097.


A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.

Fukuda D, Haines AS, Song Z, Murphy AC, Hothersall J, Stephens ER, Gurney R, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM.

PLoS One. 2011 Mar 31;6(3):e18031. doi: 10.1371/journal.pone.0018031. Erratum in: PLoS One. 2014;9(12):e116036.


Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390.

Murphy AC, Fukuda D, Song Z, Hothersall J, Cox RJ, Willis CL, Thomas CM, Simpson TJ.

Angew Chem Int Ed Engl. 2011 Mar 28;50(14):3271-4. doi: 10.1002/anie.201007029. No abstract available.


The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR.

Br J Pharmacol. 2011 Sep;164(2):317-31. doi: 10.1111/j.1476-5381.2011.01269.x.


Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.

Hothersall J, Murphy AC, Iqbal Z, Campbell G, Stephens ER, Wu J, Cooper H, Atkinson S, Williams P, Crosby J, Willis CL, Cox RJ, Simpson TJ, Thomas CM.

Appl Microbiol Biotechnol. 2011 May;90(3):1017-26. doi: 10.1007/s00253-011-3145-2.


An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S.

Chem Commun (Camb). 2010 Jun 14;46(22):3953-4. doi: 10.1039/c0cc00142b.


Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation.

Spiller F, Orrico MI, Nascimento DC, Czaikoski PG, Souto FO, Alves-Filho JC, Freitas A, Carlos D, Montenegro MF, Neto AF, Ferreira SH, Rossi MA, Hothersall JS, Assreuy J, Cunha FQ.

Am J Respir Crit Care Med. 2010 Aug 1;182(3):360-8. doi: 10.1164/rccm.200907-1145OC.


Resistance to and synthesis of the antibiotic mupirocin.

Thomas CM, Hothersall J, Willis CL, Simpson TJ.

Nat Rev Microbiol. 2010 Apr;8(4):281-9. doi: 10.1038/nrmicro2278. Review.


Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.

Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7. doi: 10.1073/pnas.0914733107.


Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.

Shields JA, Rahman AS, Arthur CJ, Crosby J, Hothersall J, Simpson TJ, Thomas CM.

Chembiochem. 2010 Jan 25;11(2):248-55. doi: 10.1002/cbic.200900565.

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