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Items: 1 to 20 of 164


Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo.

Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA.

Structure. 2019 Oct 29. pii: S0969-2126(19)30348-X. doi: 10.1016/j.str.2019.10.007. [Epub ahead of print]


A visible-light mediated three-component radical process using dithiocarbamate anion catalysis.

Cuadros S, Horwitz MA, Schweitzer-Chaput B, Melchiorre P.

Chem Sci. 2019 Apr 30;10(21):5484-5488. doi: 10.1039/c9sc00833k. eCollection 2019 Jun 7.


Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery.

Chen W, Glackin CA, Horwitz MA, Zink JI.

Acc Chem Res. 2019 Jun 18;52(6):1531-1542. doi: 10.1021/acs.accounts.9b00116. Epub 2019 May 13.


Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs.

Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ding X, Ho CM, Horwitz MA.

PLoS One. 2019 May 10;14(5):e0215607. doi: 10.1371/journal.pone.0215607. eCollection 2019. Erratum in: PLoS One. 2019 May 30;14(5):e0217670.


Photochemical generation of radicals from alkyl electrophiles using a nucleophilic organic catalyst.

Schweitzer-Chaput B, Horwitz MA, de Pedro Beato E, Melchiorre P.

Nat Chem. 2019 Feb;11(2):129-135. doi: 10.1038/s41557-018-0173-x. Epub 2018 Dec 3.


Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model.

Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA.

ACS Infect Dis. 2019 Feb 8;5(2):281-291. doi: 10.1021/acsinfecdis.8b00268. Epub 2018 Dec 10.


PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA.

Tullius MV, Nava S, Horwitz MA.

Infect Immun. 2019 Jan 24;87(2). pii: e00540-18. doi: 10.1128/IAI.00540-18. Print 2019 Feb.


Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility.

Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ho CM, Horwitz MA.

PLoS One. 2018 Nov 14;13(11):e0207469. doi: 10.1371/journal.pone.0207469. eCollection 2018.


Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles.

Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI.

ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31870-31881. doi: 10.1021/acsami.8b09069. Epub 2018 Sep 13.


Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis.

Jia Q, Horwitz MA.

Front Cell Infect Microbiol. 2018 May 15;8:154. doi: 10.3389/fcimb.2018.00154. eCollection 2018. Review.


The Francisella Type VI Secretion System.

Clemens DL, Lee BY, Horwitz MA.

Front Cell Infect Microbiol. 2018 Apr 23;8:121. doi: 10.3389/fcimb.2018.00121. eCollection 2018. Review.


Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia.

Jia Q, Bowen R, Dillon BJ, Masleša-Galić S, Chang BT, Kaidi AC, Horwitz MA.

Sci Rep. 2018 May 3;8(1):7009. doi: 10.1038/s41598-018-24581-y.


Asymmetric Organocatalytic Sulfa-Michael Addition to Enone Diesters.

Fulton JL, Horwitz MA, Bruske EL, Johnson JS.

J Org Chem. 2018 Mar 16;83(6):3385-3391. doi: 10.1021/acs.joc.8b00007. Epub 2018 Mar 7.


Enantio- and Diastereoselective Organocatalytic Conjugate Additions of Nitroalkanes to Enone Diesters.

Horwitz MA, Fulton JL, Johnson JS.

Org Lett. 2017 Nov 3;19(21):5783-5785. doi: 10.1021/acs.orglett.7b02735.


Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition.

Horwitz MA, Massolo E, Johnson JS.

Beilstein J Org Chem. 2017 Apr 24;13:762-767. doi: 10.3762/bjoc.13.75. eCollection 2017.


Local Desymmetrization through Diastereotopic Group Selection: An Enabling Strategy for Natural Product Synthesis.

Horwitz MA, Johnson JS.

European J Org Chem. 2017 Mar 17;2017(11):1381-1390. doi: 10.1002/ejoc.201601481. Epub 2017 Feb 7.


Correction to "Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters".

Griswold JA, Horwitz MA, Leiva LV, Johnson JS.

J Org Chem. 2017 Jun 2;82(11):5995. doi: 10.1021/acs.joc.7b01160. Epub 2017 May 19. No abstract available.


Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.

Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E.

Blood. 2017 Jul 20;130(3):245-257. doi: 10.1182/blood-2017-03-772715. Epub 2017 May 2.


A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles.

Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI.

J Am Chem Soc. 2017 May 17;139(19):6663-6668. doi: 10.1021/jacs.7b01278. Epub 2017 May 5.


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