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Items: 1 to 20 of 94


Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition.

Horwitz MA, Massolo E, Johnson JS.

Beilstein J Org Chem. 2017 Apr 24;13:762-767. doi: 10.3762/bjoc.13.75. eCollection 2017.


Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time.

Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ding X, Ho CM, Horwitz MA.

Nat Commun. 2017 Jan 24;8:14183. doi: 10.1038/ncomms14183.


Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge.

Jia Q, Bowen R, Lee BY, Dillon BJ, Masleša-Galić S, Horwitz MA.

Vaccine. 2016 Sep 22;34(41):4969-4978. doi: 10.1016/j.vaccine.2016.08.041. Epub 2016 Aug 28.


Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model.

Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2172-9. doi: 10.1073/pnas.1600812113. Epub 2016 Mar 28.


Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.

Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG.

PLoS Pathog. 2016 Jan 25;12(1):e1005356. doi: 10.1371/journal.ppat.1005356. eCollection 2016 Jan.


Asymmetric Organocatalytic Reductive Coupling Reactions between Benzylidene Pyruvates and Aldehydes.

Horwitz MA, Zavesky BP, Martinez-Alvarado JI, Johnson JS.

Org Lett. 2016 Jan 4;18(1):36-9. doi: 10.1021/acs.orglett.5b03127. Epub 2015 Dec 14.


Enantioselective reductive multicomponent coupling reactions between isatins and aldehydes.

Horwitz MA, Tanaka N, Yokosaka T, Uraguchi D, Johnson JS, Ooi T.

Chem Sci. 2015 Nov 1;6(11):6086-6090. Epub 2015 Jul 30.


pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice.

Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA.

Small. 2015 Oct;11(38):5066-78. doi: 10.1002/smll.201500937. Epub 2015 Jul 20.


Massively parallel delivery of large cargo into mammalian cells with light pulses.

Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY.

Nat Methods. 2015 May;12(5):439-44. doi: 10.1038/nmeth.3357. Epub 2015 Apr 6.


Atomic structure of T6SS reveals interlaced array essential to function.

Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH.

Cell. 2015 Feb 26;160(5):940-951. doi: 10.1016/j.cell.2015.02.005.


Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins.

Contreras H, Joens MS, McMath LM, Le VP, Tullius MV, Kimmey JM, Bionghi N, Horwitz MA, Fitzpatrick JA, Goulding CW.

J Biol Chem. 2014 Jun 27;289(26):18279-89. doi: 10.1074/jbc.M114.570119. Epub 2014 May 22.


The exochelins of pathogenic mycobacteria: unique, highly potent, lipid- and water-soluble hexadentate iron chelators with multiple potential therapeutic uses.

Horwitz LD, Horwitz MA.

Antioxid Redox Signal. 2014 Dec 1;21(16):2246-61. doi: 10.1089/ars.2013.5789. Epub 2014 Jun 20. Review.


Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles.

Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA.

Antimicrob Agents Chemother. 2012 May;56(5):2535-45. doi: 10.1128/AAC.06049-11. Epub 2012 Feb 21.


Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas.

Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN.

Immunity. 2011 May 27;34(5):807-19. doi: 10.1016/j.immuni.2011.03.022. Epub 2011 May 19.


Discovery and characterization of a unique mycobacterial heme acquisition system.

Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5051-6. doi: 10.1073/pnas.1009516108. Epub 2011 Mar 7.


The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome.

Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA.

Mol Cell Proteomics. 2010 Jan;9(1):32-53. doi: 10.1074/mcp.M900396-MCP200. Epub 2009 Oct 7.

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