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Items: 1 to 20 of 83


Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice.

Thomas EV, Fenton WA, McGrath J, Horwich AL.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3139-E3148. doi: 10.1073/pnas.1701465114. Epub 2017 Mar 27.


An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons.

Zhang Y, Ni W, Horwich AL, Kaczmarek LK.

J Neurosci. 2017 Feb 22;37(8):2258-2265. doi: 10.1523/JNEUROSCI.3102-16.2017. Epub 2017 Jan 24.


Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.

Hadzipasic M, Ni W, Nagy M, Steenrod N, McGinley MJ, Kaushal A, Thomas E, McCormick DA, Horwich AL.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7600-E7609. Epub 2016 Nov 7.


Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.

Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5247-5253. doi: 10.1016/j.bmcl.2016.09.051. Epub 2016 Sep 22.


GroEL/ES inhibitors as potential antibiotics.

Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3127-34. doi: 10.1016/j.bmcl.2016.04.089. Epub 2016 May 4.


Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110.

Nagy M, Fenton WA, Li D, Furtak K, Horwich AL.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5424-8. doi: 10.1073/pnas.1604885113. Epub 2016 Apr 25.


Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system.

Ambrose AJ, Fenton W, Mason DJ, Chapman E, Horwich AL.

FEBS Lett. 2015 Feb 13;589(4):497-9. doi: 10.1016/j.febslet.2015.01.008. Epub 2015 Jan 17.


Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS.

Hadzipasic M, Tahvildari B, Nagy M, Bian M, Horwich AL, McCormick DA.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16883-8. doi: 10.1073/pnas.1419497111. Epub 2014 Nov 10.


Absence of lipofuscin in motor neurons of SOD1-linked ALS mice.

Bandyopadhyay U, Nagy M, Fenton WA, Horwich AL.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11055-60. doi: 10.1073/pnas.1409314111. Epub 2014 Jul 14.


Molecular chaperones in cellular protein folding: the birth of a field.

Horwich AL.

Cell. 2014 Apr 10;157(2):285-8. doi: 10.1016/j.cell.2014.03.029.


Production of RNA for transcriptomic analysis from mouse spinal cord motor neuron cell bodies by laser capture microdissection.

Bandyopadhyay U, Fenton WA, Horwich AL, Nagy M.

J Vis Exp. 2014 Jan 13;(83):e51168. doi: 10.3791/51168.


A biochemical screen for GroEL/GroES inhibitors.

Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):786-9. doi: 10.1016/j.bmcl.2013.12.100. Epub 2014 Jan 2.


Chaperonin-mediated protein folding.

Horwich AL.

J Biol Chem. 2013 Aug 16;288(33):23622-32. doi: 10.1074/jbc.X113.497321. Epub 2013 Jun 26.


Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.

Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3489-94. doi: 10.1073/pnas.1222732110. Epub 2013 Jan 28.


RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.

Bandyopadhyay U, Cotney J, Nagy M, Oh S, Leng J, Mahajan M, Mane S, Fenton WA, Noonan JP, Horwich AL.

PLoS One. 2013;8(1):e53575. doi: 10.1371/journal.pone.0053575. Epub 2013 Jan 3.


Protein folding in the cell: an inside story.

Horwich AL.

Nat Med. 2011 Oct 11;17(10):1211-6. doi: 10.1038/nm.2468. No abstract available.


Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid.

Charbon G, Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6067-70. doi: 10.1016/j.bmcl.2011.08.057. Epub 2011 Aug 19.


Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice.

Farr GW, Ying Z, Fenton WA, Horwich AL.

Protein Sci. 2011 Oct;20(10):1692-6. doi: 10.1002/pro.700. Epub 2011 Aug 18.


Double mutant MBP refolds at same rate in free solution as inside the GroEL/GroES chaperonin chamber when aggregation in free solution is prevented.

Tyagi NK, Fenton WA, Deniz AA, Horwich AL.

FEBS Lett. 2011 Jun 23;585(12):1969-72. doi: 10.1016/j.febslet.2011.05.031. Epub 2011 May 20.


ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle.

Tyagi NK, Fenton WA, Horwich AL.

FEBS Lett. 2010 Mar 5;584(5):951-3. doi: 10.1016/j.febslet.2010.01.021. Epub 2010 Jan 17.

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