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Items: 1 to 20 of 72

1.

High-resolution three-dimensional structural microscopy by single-angle Bragg ptychography.

Hruszkewycz SO, Allain M, Holt MV, Murray CE, Holt JR, Fuoss PH, Chamard V.

Nat Mater. 2016 Nov 21. doi: 10.1038/nmat4798. [Epub ahead of print]

PMID:
27869823
2.

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

Corey DP, Holt JR.

J Neurosci. 2016 Oct 26;36(43):10921-10926.

PMID:
27798174
3.

RNA Interference Prevents Autosomal-Dominant Hearing Loss.

Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJ.

Am J Hum Genet. 2016 Jun 2;98(6):1101-13. doi: 10.1016/j.ajhg.2016.03.028.

4.

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.

Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR.

Nat Commun. 2016 May 24;7:11508. doi: 10.1038/ncomms11508.

5.

Plug-N-Play: Mechanotransduction Goes Modular.

Akyuz N, Holt JR.

Neuron. 2016 Mar 16;89(6):1128-30. doi: 10.1016/j.neuron.2016.02.041.

PMID:
26985721
6.

Recessive mutations of TMC1 associated with moderate to severe hearing loss.

Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S.

Neurogenetics. 2016 Apr;17(2):115-23. doi: 10.1007/s10048-016-0477-1.

PMID:
26879195
7.

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B.

Cell Rep. 2015 Sep 8;12(10):1606-17. doi: 10.1016/j.celrep.2015.07.058.

8.

The molecules that mediate sensory transduction in the mammalian inner ear.

Pan B, Holt JR.

Curr Opin Neurobiol. 2015 Oct;34:165-71. doi: 10.1016/j.conb.2015.06.013. Review.

9.

Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR.

Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996.

PMID:
26157030
10.

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.

Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR.

Pflugers Arch. 2015 Jan;467(1):85-94. doi: 10.1007/s00424-014-1582-3. Review.

11.

Strain imaging of nanoscale semiconductor heterostructures with x-ray Bragg projection ptychography.

Holt MV, Hruszkewycz SO, Murray CE, Holt JR, Paskiewicz DM, Fuoss PH.

Phys Rev Lett. 2014 Apr 25;112(16):165502.

PMID:
24815657
12.

Sound strategies for hearing restoration.

Géléoc GS, Holt JR.

Science. 2014 May 9;344(6184):1241062. doi: 10.1126/science.1241062. Review.

13.

Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.

Horwitz GC, Risner-Janiczek JR, Holt JR.

J Gen Physiol. 2014 Apr;143(4):481-97. doi: 10.1085/jgp.201311126.

14.

TMC function in hair cell transduction.

Holt JR, Pan B, Koussa MA, Asai Y.

Hear Res. 2014 May;311:17-24. doi: 10.1016/j.heares.2014.01.001. Review.

15.

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J.

Hum Mol Genet. 2014 May 1;23(9):2374-90. doi: 10.1093/hmg/ddt629.

16.

A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.

Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV.

Elife. 2013 Dec 10;2:e01341. doi: 10.7554/eLife.01341.

17.

Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.

Kim YH, Holt JR.

J Gen Physiol. 2013 Sep;142(3):207-23. doi: 10.1085/jgp.201311019.

18.

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR.

Neuron. 2013 Aug 7;79(3):504-15. doi: 10.1016/j.neuron.2013.06.019.

19.

Gene therapy for deaf mice goes viral.

Holt JR, Vandenberghe LH.

Mol Ther. 2012 Oct;20(10):1836-7. doi: 10.1038/mt.2012.196. No abstract available.

20.

The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.

Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN.

J Neurosci. 2012 Jul 11;32(28):9485-98. doi: 10.1523/JNEUROSCI.0311-12.2012.

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