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Items: 1 to 20 of 32


Nox2 and Cyclosporine-Induced Renal Hypoxia.

Djamali A, Wilson NA, Sadowski EA, Zha W, Niles D, Hafez O, Dorn JR, Mehner TR, Grimm PC, Hoffmann FM, Zhong W, Fain SB, Reese SR.

Transplantation. 2016 Jun;100(6):1198-210. doi: 10.1097/TP.0000000000001137.


Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.

Zhao Z, Wang L, James T, Jung Y, Kim I, Tan R, Hoffmann FM, Xu W.

Chem Biol. 2015 Dec 17;22(12):1608-21. doi: 10.1016/j.chembiol.2015.10.011. Epub 2015 Dec 3.


High-throughput screening identifies idarubicin as a preferential inhibitor of smooth muscle versus endothelial cell proliferation.

Goel SA, Guo LW, Wang B, Guo S, Roenneburg D, Ananiev GE, Hoffmann FM, Kent KC.

PLoS One. 2014 Feb 24;9(2):e89349. doi: 10.1371/journal.pone.0089349. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110098.


Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo.

Goodman CA, McNally RM, Hoffmann FM, Hornberger TA.

Mol Endocrinol. 2013 Nov;27(11):1946-57. doi: 10.1210/me.2013-1194. Epub 2013 Sep 3.


A TR-FRET-based functional assay for screening activators of CARM1.

Zeng H, Wu J, Bedford MT, Sbardella G, Hoffmann FM, Bi K, Xu W.

Chembiochem. 2013 May 10;14(7):827-35. doi: 10.1002/cbic.201300029. Epub 2013 Apr 12.


A cell-based screening system for influenza A viral RNA transcription/replication inhibitors.

Ozawa M, Shimojima M, Goto H, Watanabe S, Hatta Y, Kiso M, Furuta Y, Horimoto T, Peters NR, Hoffmann FM, Kawaoka Y.

Sci Rep. 2013;3:1106. doi: 10.1038/srep01106. Epub 2013 Jan 22.


Reversal of transforming growth factor-β induced epithelial-to-mesenchymal transition and the ZEB proteins.

Das S, Becker BN, Hoffmann FM, Mertz JE.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S28. doi: 10.1186/1755-1536-5-S1-S28. eCollection 2012.


Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds.

Tomasini-Johansson BR, Johnson IA, Hoffmann FM, Mosher DF.

Matrix Biol. 2012 Jul;31(6):360-7. doi: 10.1016/j.matbio.2012.07.003. Epub 2012 Aug 6.


Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.

Schiro MM, Stauber SE, Peterson TL, Krueger C, Darnell SJ, Satyshur KA, Drinkwater NR, Newton MA, Hoffmann FM.

PLoS One. 2011;6(9):e25021. doi: 10.1371/journal.pone.0025021. Epub 2011 Sep 19.


Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.

Krueger C, Hoffmann FM.

PLoS One. 2010 Nov 30;5(11):e15511. doi: 10.1371/journal.pone.0015511.


Identification and characterization of a novel estrogenic ligand actinopolymorphol A.

Powell E, Huang SX, Xu Y, Rajski SR, Wang Y, Peters N, Guo S, Xu HE, Hoffmann FM, Shen B, Xu W.

Biochem Pharmacol. 2010 Oct 15;80(8):1221-9. doi: 10.1016/j.bcp.2010.06.030. Epub 2010 Jun 25.


Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells.

Mehraein-Ghomi F, Basu HS, Church DR, Hoffmann FM, Wilding G.

Cancer Res. 2010 Jun 1;70(11):4560-8. doi: 10.1158/0008-5472.CAN-09-3596. Epub 2010 May 11.


Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

Luo Y, Li W, Ju J, Yuan Q, Peters NR, Hoffmann FM, Huang SX, Bugni TS, Rajski S, Osada H, Shen B.

J Am Chem Soc. 2010 May 19;132(19):6663-71. doi: 10.1021/ja9082446.


Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway.

Das S, Becker BN, Hoffmann FM, Mertz JE.

BMC Cell Biol. 2009 Dec 21;10:94. doi: 10.1186/1471-2121-10-94.


A high-throughput method to identify novel senescence-inducing compounds.

Ewald JA, Peters N, Desotelle JA, Hoffmann FM, Jarrard DF.

J Biomol Screen. 2009 Aug;14(7):853-8. doi: 10.1177/1087057109340314. Epub 2009 Jul 29.


Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

Ju J, Li W, Yuan Q, Peters NR, Hoffmann FM, Rajski SR, Osada H, Shen B.

Org Lett. 2009 Apr 2;11(7):1639-42. doi: 10.1021/ol900293j.


Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

J Am Chem Soc. 2009 Feb 4;131(4):1370-1. doi: 10.1021/ja808462p.


Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5951-4. doi: 10.1016/j.bmcl.2008.07.072. Epub 2008 Jul 24.


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