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A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.


TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).

Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Mar 29;11(3):e0151837. doi: 10.1371/journal.pone.0151837. eCollection 2016.


GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.

Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2015 Oct 6;10(10):e0139019. doi: 10.1371/journal.pone.0139019. eCollection 2015.


AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.

Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB.

Science. 2015 Jul 24;349(6246):436-40. doi: 10.1126/science.aaa1663.


Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.

Endale M, Aksoylar HI, Hoebe K.

Mediators Inflamm. 2015;2015:436017. doi: 10.1155/2015/436017. Epub 2015 Apr 7. Review.


Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.

Lampe K, Endale M, Cashman S, Fang H, Mattner J, Hildeman D, Hoebe K.

Eur J Immunol. 2015 Jul;45(7):2072-83. doi: 10.1002/eji.201445352. Epub 2015 May 22.


The aged nonhematopoietic environment impairs natural killer cell maturation and function.

Shehata HM, Hoebe K, Chougnet CA.

Aging Cell. 2015 Apr;14(2):191-9. doi: 10.1111/acel.12303. Epub 2015 Feb 9.


ATF3 is a novel regulator of mouse neutrophil migration.

Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CL.

Blood. 2014 Mar 27;123(13):2084-93. doi: 10.1182/blood-2013-06-510909. Epub 2014 Jan 27.


Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice".

Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B.

Nat Immunol. 2013 Nov;14(11):1102-3. doi: 10.1038/ni.2734. No abstract available.


Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.

Tardif V, Manenkova Y, Berger M, Hoebe K, Zuo JP, Yuan C, Kono DH, Theofilopoulos AN, Lawson BR.

Clin Immunol. 2013 May;147(2):133-43. doi: 10.1016/j.clim.2013.02.018. Epub 2013 Mar 5.


ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.


NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.

Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT.

J Immunol. 2012 May 1;188(9):4468-75. doi: 10.4049/jimmunol.1102643. Epub 2012 Mar 30.


Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.

Aksoylar HI, Lampe K, Barnes MJ, Plas DR, Hoebe K.

J Immunol. 2012 Jan 1;188(1):146-54. doi: 10.4049/jimmunol.1101206. Epub 2011 Nov 21.


C5a regulates NKT and NK cell functions in sepsis.

Fusakio ME, Mohammed JP, Laumonnier Y, Hoebe K, Köhl J, Mattner J.

J Immunol. 2011 Dec 1;187(11):5805-12. doi: 10.4049/jimmunol.1100338. Epub 2011 Nov 4.


Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.

Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K.

PLoS One. 2011;6(7):e21979. doi: 10.1371/journal.pone.0021979. Epub 2011 Jul 7.


STAT5 is critical to maintain effector CD8+ T cell responses.

Tripathi P, Kurtulus S, Wojciechowski S, Sholl A, Hoebe K, Morris SC, Finkelman FD, Grimes HL, Hildeman DA.

J Immunol. 2010 Aug 15;185(4):2116-24. doi: 10.4049/jimmunol.1000842. Epub 2010 Jul 19.


Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K.

J Immunol. 2010 Apr 1;184(7):3743-54. doi: 10.4049/jimmunol.0903164. Epub 2010 Feb 26.


Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA.

PLoS One. 2009 Oct 22;4(10):e7411. doi: 10.1371/journal.pone.0007411.


NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.

Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K.

Blood. 2009 Jun 25;113(26):6593-602. doi: 10.1182/blood-2009-01-201467. Epub 2009 Apr 30.

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