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Dev Genet. 1990;11(5-6):369-76.

Heterodimeric capping proteins constitute a highly conserved group of actin-binding proteins.

Author information

1
Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.

Abstract

The two subunits of the heterodimeric protein cap32/34, an actin-binding protein, are encoded by separate single-copy genes. We have established the genomic structure of both genes. A sequence comparison of cap32/34 with capZ from chicken skeletal muscle and two partially known sequences from Saccharomyces cerevisiae and Xenopus laevis show that heterodimeric capping proteins belong to a highly conserved group of actin-binding proteins. This conclusion is supported by the cross-reaction of polyclonal antibodies against cap32 and cap34 with proteins from lower and higher eukaryotes. In addition, a system is presented that allows the expression of truncated cap34 polypeptides under the control of the cap34 promoter.

PMID:
1710551
DOI:
10.1002/dvg.1020110508
[Indexed for MEDLINE]

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