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Items: 1 to 20 of 166

1.

Computational Network Analysis for Drug Toxicity Prediction.

Hardt C, Bauer C, Schuchhardt J, Herwig R.

Methods Mol Biol. 2018;1819:335-355. doi: 10.1007/978-1-4939-8618-7_16.

PMID:
30421412
2.

Network and Pathway Analysis of Toxicogenomics Data.

Barel G, Herwig R.

Front Genet. 2018 Oct 22;9:484. doi: 10.3389/fgene.2018.00484. eCollection 2018.

3.

Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.

Schallschmidt T, Lebek S, Altenhofen D, Damen M, Schulte Y, Knebel B, Herwig R, Rasche A, Stermann T, Kamitz A, Hallahan N, Jähnert M, Vogel H, Schürmann A, Chadt A, Al-Hasani H.

Genetics. 2018 Oct 19. pii: genetics.301578.2018. doi: 10.1534/genetics.118.301578. [Epub ahead of print]

4.

Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance.

Grasse S, Lienhard M, Frese S, Kerick M, Steinbach A, Grimm C, Hussong M, Rolff J, Becker M, Dreher F, Schirmer U, Boerno S, Ramisch A, Leschber G, Timmermann B, Grohé C, Lüders H, Vingron M, Fichtner I, Klein S, Odenthal M, Büttner R, Lehrach H, Sültmann H, Herwig R, Schweiger MR.

Genome Med. 2018 Jul 20;10(1):55. doi: 10.1186/s13073-018-0562-1.

5.

Genetics of intellectual disability in consanguineous families.

Hu H, Kahrizi K, Musante L, Fattahi Z, Herwig R, Hosseini M, Oppitz C, Abedini SS, Suckow V, Larti F, Beheshtian M, Lipkowitz B, Akhtarkhavari T, Mehvari S, Otto S, Mohseni M, Arzhangi S, Jamali P, Mojahedi F, Taghdiri M, Papari E, Soltani Banavandi MJ, Akbari S, Tonekaboni SH, Dehghani H, Ebrahimpour MR, Bader I, Davarnia B, Cohen M, Khodaei H, Albrecht B, Azimi S, Zirn B, Bastami M, Wieczorek D, Bahrami G, Keleman K, Vahid LN, Tzschach A, Gärtner J, Gillessen-Kaesbach G, Varaghchi JR, Timmermann B, Pourfatemi F, Jankhah A, Chen W, Nikuei P, Kalscheuer VM, Oladnabi M, Wienker TF, Ropers HH, Najmabadi H.

Mol Psychiatry. 2018 Jan 4. doi: 10.1038/s41380-017-0012-2. [Epub ahead of print]

PMID:
29302074
6.

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.

Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J.

Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available.

7.

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.

Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

8.

QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments.

Lienhard M, Grasse S, Rolff J, Frese S, Schirmer U, Becker M, Börno S, Timmermann B, Chavez L, Sültmann H, Leschber G, Fichtner I, Schweiger MR, Herwig R.

Nucleic Acids Res. 2017 Apr 7;45(6):e44. doi: 10.1093/nar/gkw1193.

9.

Analyzing and interpreting genome data at the network level with ConsensusPathDB.

Herwig R, Hardt C, Lienhard M, Kamburov A.

Nat Protoc. 2016 Oct;11(10):1889-907. doi: 10.1038/nprot.2016.117. Epub 2016 Sep 8.

PMID:
27606777
10.

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure.

Hebels DG, Rasche A, Herwig R, van Westen GJ, Jennen DG, Kleinjans JC.

Methods Mol Biol. 2016;1425:339-59. doi: 10.1007/978-1-4939-3609-0_15.

PMID:
27311473
11.

ToxDB: pathway-level interpretation of drug-treatment data.

Hardt C, Beber ME, Rasche A, Kamburov A, Hebels DG, Kleinjans JC, Herwig R.

Database (Oxford). 2016 Apr 13;2016. pii: baw052. doi: 10.1093/database/baw052. Print 2016.

12.

Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.

Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, Schweiger MR, Borsig L, Heikenwalder M, Lehrach H, Moelling K.

FEBS J. 2016 May;283(9):1669-88. doi: 10.1111/febs.13694. Epub 2016 Mar 25.

13.

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J.

Arch Toxicol. 2016 Sep;90(9):2215-2229. doi: 10.1007/s00204-015-1617-3. Epub 2015 Nov 2.

PMID:
26525393
14.

Venous leakage treatment revisited: pelvic venoablation using aethoxysclerol under air block technique and Valsalva maneuver.

Herwig R, Sansalone S.

Arch Ital Urol Androl. 2015 Mar 31;87(1):1-4. doi: 10.4081/aiua.2015.1.1.

15.

Genitourethral reconstruction.

Herwig R, Sansalone S, Rehder P.

Biomed Res Int. 2015;2015:535438. doi: 10.1155/2015/535438. Epub 2015 Feb 23. No abstract available.

16.

Computational modeling of drug response with applications to neuroscience.

Herwig R.

Dialogues Clin Neurosci. 2014 Dec;16(4):465-77. Review.

17.

Superficial tunica albuginea rupture as initial starting point of Peyronie's disease: a topic for interdisciplinary consideration.

Herwig R, Bayerl M.

Biomed Res Int. 2015;2015:751372. doi: 10.1155/2015/751372. Epub 2015 Jan 15.

18.

Elevated levels of carbonyl proteins in cerebrospinal fluid of patients with neurodegenerative diseases.

Rommer PS, Greilberger J, Salhofer-Polanyi S, Auff E, Leutmezer F, Herwig R.

Tohoku J Exp Med. 2014 Dec;234(4):313-7. doi: 10.1620/tjem.234.313.

19.

diXa: a data infrastructure for chemical safety assessment.

Hendrickx DM, Aerts HJ, Caiment F, Clark D, Ebbels TM, Evelo CT, Gmuender H, Hebels DG, Herwig R, Hescheler J, Jennen DG, Jetten MJ, Kanterakis S, Keun HC, Matser V, Overington JP, Pilicheva E, Sarkans U, Segura-Lepe MP, Sotiriadou I, Wittenberger T, Wittwehr C, Zanzi A, Kleinjans JC.

Bioinformatics. 2015 May 1;31(9):1505-7. doi: 10.1093/bioinformatics/btu827. Epub 2014 Dec 12.

20.

Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.

Hülsmann HJ, Rolff J, Bender C, Jarahian M, Korf U, Herwig R, Fröhlich H, Thomas M, Merk J, Fichtner I, Sültmann H, Kuner R.

Lung Cancer. 2014 Nov;86(2):151-7. doi: 10.1016/j.lungcan.2014.09.001. Epub 2014 Sep 10.

PMID:
25240516

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