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Items: 1 to 20 of 25


How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology.

Wittwehr C, Aladjov H, Ankley G, Byrne HJ, de Knecht J, Heinzle E, Klambauer G, Landesmann B, Luijten M, MacKay C, Maxwell G, Meek ME, Paini A, Perkins E, Sobanski T, Villeneuve D, Waters KM, Whelan M.

Toxicol Sci. 2017 Feb;155(2):326-336. doi: 10.1093/toxsci/kfw207. Review.


Segmented linear modeling of CHO fed-batch culture and its application to large scale production.

Ben Yahia B, Gourevitch B, Malphettes L, Heinzle E.

Biotechnol Bioeng. 2017 Apr;114(4):785-797. doi: 10.1002/bit.26214.


Macroscopic modeling of mammalian cell growth and metabolism.

Ben Yahia B, Malphettes L, Heinzle E.

Appl Microbiol Biotechnol. 2015 Sep;99(17):7009-24. doi: 10.1007/s00253-015-6743-6. Review.


N-acetylation and phosphorylation of Sec complex subunits in the ER membrane.

Soromani C, Zeng N, Hollemeyer K, Heinzle E, Klein MC, Tretter T, Seaman MN, Römisch K.

BMC Cell Biol. 2012 Dec 13;13:34. doi: 10.1186/1471-2121-13-34.


Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine.

Peifer S, Barduhn T, Zimmet S, Volmer DA, Heinzle E, Schneider K.

Microb Cell Fact. 2012 Oct 24;11:138. doi: 10.1186/1475-2859-11-138.


Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay.

Mueller D, Tascher G, Damm G, Nüssler AK, Heinzle E, Noor F.

Cytotechnology. 2013 Mar;65(2):297-305. doi: 10.1007/s10616-012-9486-6.


Characterisation of cultivation of the human cell line AGE1.HN.AAT.

Schräder E, Scholz S, Niklas J, Rath A, Barradas OP, Jandt U, Sandig V, Rose T, Pörtner R, Reichl U, Zeng AP, Heinzle E, Noll T.

BMC Proc. 2011 Nov 22;5 Suppl 8:P87. doi: 10.1186/1753-6561-5-S8-P87. No abstract available.


Producer vs. parental cell - metabolic changes and burden upon α1-antitrypsin production in AGE1.HN(®).

Niklas J, Priesnitz C, Sandig V, Rose T, Heinzle E.

BMC Proc. 2011 Nov 22;5 Suppl 8:P85. doi: 10.1186/1753-6561-5-S8-P85. No abstract available.


Compartmentation and channelling of metabolites in the human cell line AGE1.HN(®).

Niklas J, Sandig V, Heinzle E.

BMC Proc. 2011 Nov 22;5 Suppl 8:P84. doi: 10.1186/1753-6561-5-S8-P84. No abstract available.


Evaluation of sampling and quenching procedures for the analysis of intracellular metabolites in CHO suspension cells.

Wahrheit J, Niklas J, Heinzle E.

BMC Proc. 2011 Nov 22;5 Suppl 8:P82. doi: 10.1186/1753-6561-5-S8-P82. No abstract available.


Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.

Niklas J, Schräder E, Sandig V, Noll T, Heinzle E.

Bioprocess Biosyst Eng. 2011 Jun;34(5):533-45. doi: 10.1007/s00449-010-0502-y.


Zinc ion-induced domain organization in metallo-beta-lactamases: a flexible "zinc arm" for rapid metal ion transfer?

Selevsek N, Rival S, Tholey A, Heinzle E, Heinz U, Hemmingsen L, Adolph HW.

J Biol Chem. 2009 Jun 12;284(24):16419-31. doi: 10.1074/jbc.M109.001305.


Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening.

Schneider K, Krömer JO, Wittmann C, Alves-Rodrigues I, Meyerhans A, Diez J, Heinzle E.

Microb Cell Fact. 2009 Jan 30;8:12. doi: 10.1186/1475-2859-8-12.


Microplates with integrated oxygen sensing for medium optimization in animal cell culture.

Deshpande RR, Wittmann C, Heinzle E.

Cytotechnology. 2004 Sep;46(1):1-8. doi: 10.1007/s10616-004-6401-9.


Measurement of oxygen uptake and carbon dioxide production rates ofmammalian cells using membrane mass spectrometry.

Oezemre A, Heinzle E.

Cytotechnology. 2001 Nov;37(3):153-62. doi: 10.1023/A:1020554704846.


Esterase autodisplay: enzyme engineering and whole-cell activity determination in microplates with pH sensors.

Schultheiss E, Weiss S, Winterer E, Maas R, Heinzle E, Jose J.

Appl Environ Microbiol. 2008 Aug;74(15):4782-91. doi: 10.1128/AEM.01575-07.


Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification.

Yang TH, Frick O, Heinzle E.

BMC Syst Biol. 2008 Mar 26;2:29. doi: 10.1186/1752-0509-2-29.


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