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Items: 1 to 20 of 86


Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence.

Goncheva MI, Flannagan RS, Sterling BE, Laakso HA, Friedrich NC, Kaiser JC, Watson DW, Wilson CH, Sheldon JR, McGavin MJ, Kiser PK, Heinrichs DE.

Nat Commun. 2019 Feb 15;10(1):775. doi: 10.1038/s41467-019-08724-x.


A Fluorescence Based-Proliferation Assay for the Identification of Replicating Bacteria Within Host Cells.

Flannagan RS, Heinrichs DE.

Front Microbiol. 2018 Dec 12;9:3084. doi: 10.3389/fmicb.2018.03084. eCollection 2018.


DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus.

Alnaseri H, Kuiack RC, Ferguson KA, Schneider JET, Heinrichs DE, McGavin MJ.

J Bacteriol. 2019 Jan 11;201(3). pii: e00602-18. doi: 10.1128/JB.00602-18. Print 2019 Feb 1.


Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation.

Kaiser JC, Heinrichs DE.

MBio. 2018 Sep 4;9(5). pii: e01188-18. doi: 10.1128/mBio.01188-18. Review.


Correction: Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2018 Jul 27;14(7):e1007564. doi: 10.1371/journal.pgen.1007564. eCollection 2018 Jul.


Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages.

Flannagan RS, Kuiack RC, McGavin MJ, Heinrichs DE.

MBio. 2018 Jul 17;9(4). pii: e01143-18. doi: 10.1128/mBio.01143-18.


The surreptitious survival of the emerging pathogen Staphylococcus lugdunensis within macrophages as an immune evasion strategy.

Flannagan RS, Watson DW, Surewaard BGJ, Kubes P, Heinrichs DE.

Cell Microbiol. 2018 Nov;20(11):e12869. doi: 10.1111/cmi.12869. Epub 2018 Aug 7.


SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.

Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP.

J Biol Chem. 2018 Apr 20;293(16):6147-6160. doi: 10.1074/jbc.RA118.001875. Epub 2018 Feb 26.


Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE.

PLoS Genet. 2018 Jan 22;14(1):e1007159. doi: 10.1371/journal.pgen.1007159. eCollection 2018 Jan.


The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence.

Kaiser JC, Sen S, Sinha A, Wilkinson BJ, Heinrichs DE.

Mol Microbiol. 2016 Dec;102(5):850-864. doi: 10.1111/mmi.13495. Epub 2016 Sep 27.


Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2016 Aug 30;12(8):e1006246. doi: 10.1371/journal.pgen.1006246. eCollection 2016 Aug. Erratum in: PLoS Genet. 2018 Jul 27;14(7):e1007564.


Iron Acquisition Strategies of Bacterial Pathogens.

Sheldon JR, Laakso HA, Heinrichs DE.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0010-2015. Review.


Paradoxical acclimation responses in the thermal performance of insect immunity.

Ferguson LV, Heinrichs DE, Sinclair BJ.

Oecologia. 2016 May;181(1):77-85. doi: 10.1007/s00442-015-3529-6. Epub 2016 Feb 5.


Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.

Kobylarz MJ, Grigg JC, Liu Y, Lee MS, Heinrichs DE, Murphy ME.

Biochemistry. 2016 Feb 16;55(6):927-39. doi: 10.1021/acs.biochem.5b01045. Epub 2016 Feb 3.


Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus.

Flannagan RS, Heit B, Heinrichs DE.

Pathogens. 2015 Nov 27;4(4):826-68. doi: 10.3390/pathogens4040826. Review.


A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B in Staphylococcus aureus.

Laakso HA, Marolda CL, Pinter TB, Stillman MJ, Heinrichs DE.

J Biol Chem. 2016 Jan 1;291(1):29-40. doi: 10.1074/jbc.M115.696625. Epub 2015 Nov 3.


Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination.

Flannagan RS, Heit B, Heinrichs DE.

Cell Microbiol. 2016 Apr;18(4):514-35. doi: 10.1111/cmi.12527. Epub 2015 Oct 26.


Recent developments in understanding the iron acquisition strategies of gram positive pathogens.

Sheldon JR, Heinrichs DE.

FEMS Microbiol Rev. 2015 Jul;39(4):592-630. doi: 10.1093/femsre/fuv009. Epub 2015 Apr 9. Review.


Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.

Alnaseri H, Arsic B, Schneider JE, Kaiser JC, Scinocca ZC, Heinrichs DE, McGavin MJ.

J Bacteriol. 2015 Jun;197(11):1893-905. doi: 10.1128/JB.02607-14. Epub 2015 Mar 23.


Involvement of reductases IruO and NtrA in iron acquisition by Staphylococcus aureus.

Hannauer M, Arifin AJ, Heinrichs DE.

Mol Microbiol. 2015 Jun;96(6):1192-210. doi: 10.1111/mmi.13000. Epub 2015 Apr 11.

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