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Items: 1 to 20 of 39


ATP release from bladder urothelium and serosa in a rat model of partial bladder outlet obstruction.

Shiina K, Hayashida KI, Ishikawa K, Kawatani M.

Biomed Res. 2016;37(5):299-304.


Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.

Kimura M, Eisenach JC, Hayashida K.

Pain. 2016 Sep;157(9):2024-32. doi: 10.1097/j.pain.0000000000000608.


Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.

Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida K, Wang F, Martin TJ, Eisenach JC, Peters CM.

J Pain. 2016 Feb;17(2):190-202. doi: 10.1016/j.jpain.2015.10.009. Epub 2015 Nov 3.


Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.

Kimura M, Suto T, Eisenach JC, Hayashida K.

Neurosci Lett. 2015 Nov 3;608:18-22. doi: 10.1016/j.neulet.2015.09.036. Epub 2015 Oct 9.


Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus.

Kimura M, Suto T, Morado-Urbina CE, Peters CM, Eisenach JC, Hayashida K.

Anesthesiology. 2015 Oct;123(4):899-908. doi: 10.1097/ALN.0000000000000796.


Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.

Peters CM, Hayashida K, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC.

Anesthesiology. 2015 Apr;122(4):895-907. doi: 10.1097/ALN.0000000000000593.


Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.

Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida K, Ririe DG, Eisenach JC.

J Neurophysiol. 2015 Jan 1;113(1):100-9. doi: 10.1152/jn.00506.2014. Epub 2014 Oct 1.


Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.

Suto T, Eisenach JC, Hayashida K.

Pain. 2014 Oct;155(10):1935-42. doi: 10.1016/j.pain.2014.05.014. Epub 2014 May 15.


Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.

Suto T, Severino AL, Eisenach JC, Hayashida K.

Neuropharmacology. 2014 Jun;81:95-100. doi: 10.1016/j.neuropharm.2014.01.040. Epub 2014 Feb 1.


Substance P-saporin for bone cancer pain in dogs: can man's best friend solve the lost in translation problem in analgesic development?

Hayashida K.

Anesthesiology. 2013 Nov;119(5):999-1000. doi: 10.1097/ALN.0b013e3182a951a2. No abstract available.


Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.

Yoshizumi M, Eisenach JC, Hayashida K.

J Pain. 2013 Nov;14(11):1485-91. doi: 10.1016/j.jpain.2013.07.007. Epub 2013 Sep 7.


Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.

Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC.

Anesthesiology. 2013 Jan;118(1):152-9. doi: 10.1097/ALN.0b013e318278cd21.


Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.

Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H.

Anesthesiology. 2013 Jan;118(1):173-80. doi: 10.1097/ALN.0b013e318277a81c.


Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.

Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC.

Anesthesiology. 2012 Aug;117(2):389-98. doi: 10.1097/ALN.0b013e318260d381.


Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.

Yoshizumi M, Parker RA, Eisenach JC, Hayashida K.

Anesthesiology. 2012 Jun;116(6):1347-53. doi: 10.1097/ALN.0b013e318254e6fd.


Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.

Yoshizumi M, Eisenach JC, Hayashida K.

Eur J Pharmacol. 2012 Feb 29;677(1-3):87-92. doi: 10.1016/j.ejphar.2011.12.015. Epub 2011 Dec 21.


Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.

Hayashida K, Peters CM, Gutierrez S, Eisenach JC.

J Pain. 2012 Jan;13(1):49-57. doi: 10.1016/j.jpain.2011.09.009. Epub 2011 Dec 11.


Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.

Hobo S, Hayashida K, Eisenach JC.

Anesth Analg. 2012 Feb;114(2):442-9. doi: 10.1213/ANE.0b013e31823b1bc8. Epub 2011 Nov 21.


Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.

Hobo S, Eisenach JC, Hayashida K.

Neurosci Lett. 2011 Sep 8;502(1):52-5. doi: 10.1016/j.neulet.2011.07.023. Epub 2011 Jul 23.

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