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Items: 1 to 20 of 37

1.

Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models.

O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC.

Elife. 2017 May 2;6. pii: e20752. doi: 10.7554/eLife.20752.

2.

In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects.

Sorkaç A, Alcantara IC, Hart AC.

PLoS One. 2016 Dec 9;11(12):e0167963. doi: 10.1371/journal.pone.0167963. eCollection 2016.

3.

Decreased function of survival motor neuron protein impairs endocytic pathways.

Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4377-86. doi: 10.1073/pnas.1600015113. Epub 2016 Jul 11.

4.

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC.

Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22.

5.

A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.

Fry AL, Laboy JT, Huang H, Hart AC, Norman KR.

Genetics. 2016 Mar;202(3):1153-66. doi: 10.1534/genetics.115.183038. Epub 2016 Jan 22.

6.

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

Wan H, Schroeder GM, Hart AC, Inghrim J, Grebinski J, Tokarski JS, Lorenzi MV, You D, Mcdevitt T, Penhallow B, Vuppugalla R, Zhang Y, Gu X, Iyer R, Lombardo LJ, Trainor GL, Ruepp S, Lippy J, Blat Y, Sack JS, Khan JA, Stefanski K, Sleczka B, Mathur A, Sun JH, Wong MK, Wu DR, Li P, Gupta A, Arunachalam PN, Pragalathan B, Narayanan S, K C N, Kuppusamy P, Purandare AV.

ACS Med Chem Lett. 2015 Jul 12;6(8):850-5. doi: 10.1021/acsmedchemlett.5b00226. eCollection 2015 Aug 13.

7.

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.

Hart AC, Schroeder GM, Wan H, Grebinski J, Inghrim J, Kempson J, Guo J, Pitts WJ, Tokarski JS, Sack JS, Khan JA, Lippy J, Lorenzi MV, You D, McDevitt T, Vuppugalla R, Zhang Y, Lombardo LJ, Trainor GL, Purandare AV.

ACS Med Chem Lett. 2015 Jul 10;6(8):845-9. doi: 10.1021/acsmedchemlett.5b00225. eCollection 2015 Aug 13.

8.

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.

Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25.

9.

Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling.

Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC.

Sleep. 2014 Sep 1;37(9):1439-51. doi: 10.5665/sleep.3990.

10.

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.

Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2371-80. doi: 10.1073/pnas.1301738110. Epub 2013 Jun 11.

11.

The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.

Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG.

Mol Biol Cell. 2013 Jun;24(12):1863-71. doi: 10.1091/mbc.E13-01-0042. Epub 2013 Apr 24.

12.

The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.

Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC.

J Neurosci. 2013 Apr 10;33(15):6557-62. doi: 10.1523/JNEUROSCI.1536-12.2013.

13.

Do C. elegans sleep? A closer look.

Singh K, Huang H, Hart AC.

Sleep. 2013 Mar 1;36(3):307-8. doi: 10.5665/sleep.2436. No abstract available.

14.

Local RNA translation at the synapse and in disease.

Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B.

J Neurosci. 2011 Nov 9;31(45):16086-93. doi: 10.1523/JNEUROSCI.4105-11.2011. Review.

15.

A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.

Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM.

Cell. 2011 Nov 11;147(4):840-52. doi: 10.1016/j.cell.2011.09.045. Epub 2011 Oct 27.

16.

C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence.

Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC.

Curr Biol. 2011 May 24;21(10):825-34. doi: 10.1016/j.cub.2011.04.010. Epub 2011 May 5.

17.

PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response.

Hyde R, Corkins ME, Somers GA, Hart AC.

Genes Brain Behav. 2011 Apr;10(3):286-98. doi: 10.1111/j.1601-183X.2010.00667.x. Epub 2011 Jan 10.

18.

Conserved genes act as modifiers of invertebrate SMN loss of function defects.

Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.

PLoS Genet. 2010 Oct 28;6(10):e1001172. doi: 10.1371/journal.pgen.1001172.

19.

Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans.

Haspel G, O'Donovan MJ, Hart AC.

J Neurosci. 2010 Aug 18;30(33):11151-6. doi: 10.1523/JNEUROSCI.2244-10.2010.

20.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

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