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Natural reassortants between potentially zoonotic avian influenza viruses H5N1 and H9N2 from Egypt display distinct pathogenic phenotypes in experimentally infected chickens and ferrets.

Naguib MM, Ulrich R, Kasbohm E, Eng CLP, Hoffmann D, Grund C, Beer M, Harder TC.

J Virol. 2017 Sep 20. pii: JVI.01300-17. doi: 10.1128/JVI.01300-17. [Epub ahead of print]


Insights into genetic diversity and biological propensities of potentially zoonotic avian influenza H9N2 viruses circulating in Egypt.

Naguib MM, Arafa AS, Parvin R, Beer M, Vahlenkamp T, Harder TC.

Virology. 2017 Aug 29;511:165-174. doi: 10.1016/j.virol.2017.08.028. [Epub ahead of print]


Heterologous post-infection immunity against Egyptian avian influenza virus (AIV) H9N2 modulates the course of subsequent infection by highly pathogenic AIV H5N1, but vaccination immunity does not.

Naguib MM, Grund C, Arafa AS, Abdelwhab EM, Beer M, Harder TC.

J Gen Virol. 2017 Jun;98(6):1169-1173. doi: 10.1099/jgv.0.000767. Epub 2017 Jun 8.


Predicted vs observed effectiveness of outer membrane vesicle (OMV) vaccines against meningococcal serogroup B disease: Systematic review.

Harder T, Koch J, Wichmann O, Hellenbrand W.

J Infect. 2017 Aug;75(2):81-94. doi: 10.1016/j.jinf.2017.05.001. Epub 2017 May 6.


Risk of Intussusception After Rotavirus Vaccination.

Koch J, Harder T, von Kries R, Wichmann O.

Dtsch Arztebl Int. 2017 Apr 14;114(15):255-262. doi: 10.3238/arztebl.2017.0255.


New real time and conventional RT-PCRs for updated molecular diagnosis of infectious bronchitis virus infection (IBV) in chickens in Egypt associated with frequent co-infections with avian influenza and Newcastle Disease viruses.

Naguib MM, El-Kady MF, Lüschow D, Hassan KE, Arafa AS, El-Zanaty A, Hassan MK, Hafez HM, Grund C, Harder TC.

J Virol Methods. 2017 Jul;245:19-27. doi: 10.1016/j.jviromet.2017.02.018. Epub 2017 Mar 21.


Isolation and genetic characterization of a novel H5N1 virus from a vaccinated meat-turkeys flock in Egypt.

Salaheldin AH, Veits J, Abd El-Hamid HS, Harder TC, Devrishov D, Mettenleiter TC, Hafez HM, Abdelwhab EM.

Virol J. 2017 Mar 9;14(1):48. doi: 10.1186/s12985-017-0697-5.


Novel real-time PCR-based patho- and phylotyping of potentially zoonotic avian influenza A subtype H5 viruses at risk of incursion into Europe in 2017.

Naguib MM, Graaf A, Fortin A, Luttermann C, Wernery U, Amarin N, Hussein HA, Sultan H, Al Adhadh B, Hassan MK, Beer M, Monne I, Harder TC.

Euro Surveill. 2017 Jan 5;22(1). pii: 30435. doi: 10.2807/1560-7917.ES.2017.22.1.30435. No abstract available.


Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) against Pneumococcal Disease in the Elderly: Systematic Review and Meta-Analysis.

Falkenhorst G, Remschmidt C, Harder T, Hummers-Pradier E, Wichmann O, Bogdan C.

PLoS One. 2017 Jan 6;12(1):e0169368. doi: 10.1371/journal.pone.0169368. eCollection 2017. Review.


Outbreaks among Wild Birds and Domestic Poultry Caused by Reassorted Influenza A(H5N8) Clade Viruses, Germany, 2016.

Pohlmann A, Starick E, Harder T, Grund C, Höper D, Globig A, Staubach C, Dietze K, Strebelow G, Ulrich RG, Schinköthe J, Teifke JP, Conraths FJ, Mettenleiter TC, Beer M.

Emerg Infect Dis. 2017 Apr;23(4):633-636. doi: 10.3201/eid2304.161949. Epub 2017 Apr 15.


Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016.

Adlhoch C, Brown IH, Angelova SG, Bálint Á, Bouwstra R, Buda S, Castrucci MR, Dabrera G, Dán Á, Grund C, Harder T, van der Hoek W, Krisztalovics K, Parry-Ford F, Popescu R, Wallensten A, Zdravkova A, Zohari S, Tsolova S, Penttinen P.

Euro Surveill. 2016 Dec 8;21(49). pii: 30419. doi: 10.2807/1560-7917.ES.2016.21.49.30419.


Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift.

Abdelwhab EM, Veits J, Tauscher K, Ziller M, Grund C, Hassan MK, Shaheen M, Harder TC, Teifke J, Stech J, Mettenleiter TC.

J Gen Virol. 2016 Dec;97(12):3193-3204. doi: 10.1099/jgv.0.000648. Epub 2016 Oct 28.


Effectiveness, immunogenicity and safety of 23-valent pneumococcal polysaccharide vaccine revaccinations in the elderly: a systematic review.

Remschmidt C, Harder T, Wichmann O, Bogdan C, Falkenhorst G.

BMC Infect Dis. 2016 Nov 25;16(1):711. Review.


Background paper to the updated pneumococcal vaccination recommendation for older adults in Germany.

Falkenhorst G, Remschmidt C, Harder T, Wichmann O, Glodny S, Hummers-Pradier E, Ledig T, Bogdan C.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Dec;59(12):1623-1657. German. No abstract available.


Epidemiological and Molecular Analysis of an Outbreak of Highly Pathogenic Avian Influenza H5N8 clade in a German Zoo: Effective Disease Control with Minimal Culling.

Globig A, Starick E, Homeier T, Pohlmann A, Grund C, Wolf P, Zimmermann A, Wolf C, Heim D, Schlößer H, Zander S, Beer M, Conraths FJ, Harder TC.

Transbound Emerg Dis. 2016 Nov 15. doi: 10.1111/tbed.12570. [Epub ahead of print]


Hintergrundpapier der STIKO: Evaluation der bestehenden Influenzaimpfempfehlung für Indikationsgruppen und für Senioren (Standardimpfung ab 60 Jahren).

Remschmidt C, Harder T, Wichmann O, Garbe E, Ledig T, Terhardt M, Wicker S, Zepp F, Mertens T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Dec;59(12):1606-1622. German. No abstract available.


A genetically engineered H5 protein expressed in insect cells confers protection against different clades of H5N1 highly pathogenic avian influenza viruses in chickens.

Oliveira Cavalcanti M, Vaughn E, Capua I, Cattoli G, Terregino C, Harder T, Grund C, Vega C, Robles F, Franco J, Darji A, Arafa AS, Mundt E.

Avian Pathol. 2017 Apr;46(2):224-233. doi: 10.1080/03079457.2016.1250866. Epub 2017 Jan 27.


Direct observation of ice nucleation events on individual atmospheric particles.

Wang B, Knopf DA, China S, Arey BW, Harder TH, Gilles MK, Laskin A.

Phys Chem Chem Phys. 2016 Nov 2;18(43):29721-29731.


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