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Items: 1 to 20 of 106


Single-molecule analysis of steroid receptor and cofactor action in living cells.

Paakinaho V, Presman DM, Ball DA, Johnson TA, Schiltz RL, Levitt P, Mazza D, Morisaki T, Karpova TS, Hager GL.

Nat Commun. 2017 Jun 21;8:15896. doi: 10.1038/ncomms15896.


High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.

Siersbæk M, Varticovski L, Yang S, Baek S, Nielsen R, Mandrup S, Hager GL, Chung JH, Grøntved L.

Sci Rep. 2017 Jan 10;7:40220. doi: 10.1038/srep40220.


More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?

Presman DM, Hager GL.

Transcription. 2017 Jan;8(1):32-39. doi: 10.1080/21541264.2016.1249045. Epub 2016 Oct 20.


DNA binding triggers tetramerization of the glucocorticoid receptor in live cells.

Presman DM, Ganguly S, Schiltz RL, Johnson TA, Karpova TS, Hager GL.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8236-41. doi: 10.1073/pnas.1606774113. Epub 2016 Jul 5.


Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions.

Swinstead EE, Miranda TB, Paakinaho V, Baek S, Goldstein I, Hawkins M, Karpova TS, Ball D, Mazza D, Lavis LD, Grimm JB, Morisaki T, Grøntved L, Presman DM, Hager GL.

Cell. 2016 Apr 21;165(3):593-605. doi: 10.1016/j.cell.2016.02.067. Epub 2016 Apr 7.


Divergent Binding and Transactivation by Two Related Steroid Receptors at the Same Response Element.

Tesikova M, Dezitter X, Nenseth HZ, Klokk TI, Mueller F, Hager GL, Saatcioglu F.

J Biol Chem. 2016 May 27;291(22):11899-910. doi: 10.1074/jbc.M115.684480. Epub 2016 Apr 7.


Cajal bodies are linked to genome conformation.

Wang Q, Sawyer IA, Sung MH, Sturgill D, Shevtsov SP, Pegoraro G, Hakim O, Baek S, Hager GL, Dundr M.

Nat Commun. 2016 Mar 21;7:10966. doi: 10.1038/ncomms10966.


Genome-wide footprinting: ready for prime time?

Sung MH, Baek S, Hager GL.

Nat Methods. 2016 Mar;13(3):222-228. doi: 10.1038/nmeth.3766.


Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation.

Thompson B, Varticovski L, Baek S, Hager GL.

PLoS One. 2016 Feb 18;11(2):e0148619. doi: 10.1371/journal.pone.0148619. eCollection 2016.


Chromatin structure and gene regulation: a dynamic view of enhancer function.

Stavreva DA, Hager GL.

Nucleus. 2015;6(6):442-8. doi: 10.1080/19491034.2015.1107689. Epub 2016 Jan 14.


Transcriptional and Chromatin Regulation during Fasting - The Genomic Era.

Goldstein I, Hager GL.

Trends Endocrinol Metab. 2015 Dec;26(12):699-710. doi: 10.1016/j.tem.2015.09.005. Epub 2015 Oct 29. Review.


Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.

Muratcioglu S, Presman DM, Pooley JR, Grøntved L, Hager GL, Nussinov R, Keskin O, Gursoy A.

Biophys J. 2015 Sep 15;109(6):1227-39. doi: 10.1016/j.bpj.2015.06.044. Epub 2015 Aug 13.


Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing.

Stavreva DA, Coulon A, Baek S, Sung MH, John S, Stixova L, Tesikova M, Hakim O, Miranda T, Hawkins M, Stamatoyannopoulos JA, Chow CC, Hager GL.

Genome Res. 2015 Jun;25(6):845-57. doi: 10.1101/gr.184168.114. Epub 2015 Feb 12.


DNase footprint signatures are dictated by factor dynamics and DNA sequence.

Sung MH, Guertin MJ, Baek S, Hager GL.

Mol Cell. 2014 Oct 23;56(2):275-85. doi: 10.1016/j.molcel.2014.08.016. Epub 2014 Sep 18.


Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure.

Guertin MJ, Zhang X, Anguish L, Kim S, Varticovski L, Lis JT, Hager GL, Coonrod SA.

PLoS Genet. 2014 Sep 11;10(9):e1004613. doi: 10.1371/journal.pgen.1004613. eCollection 2014 Sep.


Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells.

Nenseth HZ, Dezitter X, Tesikova M, Mueller F, Klokk TI, Hager GL, Saatcioglu F.

PLoS One. 2014 Aug 18;9(8):e105204. doi: 10.1371/journal.pone.0105204. eCollection 2014.


Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.

Guertin MJ, Zhang X, Coonrod SA, Hager GL.

Mol Endocrinol. 2014 Sep;28(9):1522-33. doi: 10.1210/me.2014-1130. Epub 2014 Jul 22.


Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.

Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.

PLoS Biol. 2014 Mar 18;12(3):e1001813. doi: 10.1371/journal.pbio.1001813. eCollection 2014 Mar.


Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling.

Sung MH, Li N, Lao Q, Gottschalk RA, Hager GL, Fraser ID.

Sci Signal. 2014 Jan 14;7(308):ra6. doi: 10.1126/scisignal.2004764.


Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.

Cell. 2013 Dec 19;155(7):1507-20. doi: 10.1016/j.cell.2013.11.039.

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