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Items: 1 to 20 of 31


Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.

Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C.

Blood. 2020 Jan 9;135(2):108-120. doi: 10.1182/blood.2019001438.


Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.

Franqui-Machin R, Hao M, Bai H, Gu Z, Zhan X, Habelhah H, Jethava Y, Qiu L, Frech I, Tricot G, Zhan F.

J Clin Invest. 2018 Jul 2;128(7):2877-2893. doi: 10.1172/JCI98765. Epub 2018 Jun 4.


TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.

Zhang L, Blackwell K, Workman LM, Gibson-Corley KN, Olivier AK, Bishop GA, Habelhah H.

J Cell Sci. 2016 Apr 1;129(7):1455-67. doi: 10.1242/jcs.180554. Epub 2016 Feb 12.


RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival.

Zhang L, Blackwell K, Workman LM, Chen S, Pope MR, Janz S, Habelhah H.

Mol Cell Biol. 2015 Oct;35(19):3324-38. doi: 10.1128/MCB.00692-15. Epub 2015 Jul 20.


TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways.

Zhang L, Dittmer MR, Blackwell K, Workman LM, Hostager B, Habelhah H.

Cell Signal. 2015 Feb;27(2):306-14. doi: 10.1016/j.cellsig.2014.11.014. Epub 2014 Nov 18.


The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.

Hadweh P, Habelhah H, Kieff E, Mosialos G, Hatzivassiliou E.

Cell Signal. 2014 Dec;26(12):2730-7. doi: 10.1016/j.cellsig.2014.08.001. Epub 2014 Aug 16.


Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis.

Kanda Y, Kawaguchi T, Kuramitsu Y, Kitagawa T, Kobayashi T, Takahashi N, Tazawa H, Habelhah H, Hamada J, Kobayashi M, Hirahata M, Onuma K, Osaki M, Nakamura K, Kitagawa T, Hosokawa M, Okada F.

Proteomics. 2014 May;14(9):1031-41. doi: 10.1002/pmic.201300414. Epub 2014 Mar 25.


TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.

Workman LM, Habelhah H.

Cell Signal. 2013 Aug;25(8):1654-64. doi: 10.1016/j.cellsig.2013.04.005. Epub 2013 Apr 21. Review.


Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.

Blackwell K, Zhang L, Workman LM, Ting AT, Iwai K, Habelhah H.

Mol Cell Biol. 2013 May;33(10):1901-15. doi: 10.1128/MCB.01416-12. Epub 2013 Mar 4.


IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.

Shen RR, Zhou AY, Kim E, Lim E, Habelhah H, Hahn WC.

Mol Cell Biol. 2012 Dec;32(23):4756-68. doi: 10.1128/MCB.00468-12. Epub 2012 Sep 24.


TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.

Zhang L, Blackwell K, Altaeva A, Shi Z, Habelhah H.

Mol Biol Cell. 2011 Jan 1;22(1):128-40. doi: 10.1091/mbc.E10-06-0556. Epub 2010 Nov 30.


The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

Zhang L, Blackwell K, Shi Z, Habelhah H.

J Mol Biol. 2010 Feb 26;396(3):528-39. doi: 10.1016/j.jmb.2010.01.008. Epub 2010 Jan 11.


TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.

Zhang L, Blackwell K, Thomas GS, Sun S, Yeh WC, Habelhah H.

J Mol Biol. 2009 Jun 12;389(3):495-510. doi: 10.1016/j.jmb.2009.04.054. Epub 2009 May 3.


Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.

Thomas GS, Zhang L, Blackwell K, Habelhah H.

Cancer Res. 2009 Apr 15;69(8):3665-72. doi: 10.1158/0008-5472.CAN-08-4867. Epub 2009 Mar 31.


TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.

Blackwell K, Zhang L, Thomas GS, Sun S, Nakano H, Habelhah H.

Mol Cell Biol. 2009 Jan;29(2):303-14. doi: 10.1128/MCB.00699-08. Epub 2008 Nov 3.


RACK1 mediates activation of JNK by protein kinase C [corrected].

López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang LH, Ronai Z.

Mol Cell. 2005 Aug 5;19(3):309-20. Erratum in: Mol Cell. 2005 Aug 19;19(4):578-9.


Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.

Habelhah H, Laine A, Erdjument-Bromage H, Tempst P, Gershwin ME, Bowtell DD, Ronai Z.

J Biol Chem. 2004 Dec 17;279(51):53782-8. Epub 2004 Oct 5.


Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z.

Cell. 2004 Jun 25;117(7):941-52.


Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z.

EMBO J. 2004 Jan 28;23(2):322-32. Epub 2004 Jan 8.

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