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Items: 1 to 20 of 84


Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients.

Ahmed A, Schwaderer J, Hantusch A, Kolho KL, Brunner T.

Genes Immun. 2019 Jan 28. doi: 10.1038/s41435-019-0056-1. [Epub ahead of print]


Metabolomics Profiling Reveals Rehmanniae Radix Preparata Extract Protects against Glucocorticoid-Induced Osteoporosis Mainly via Intervening Steroid Hormone Biosynthesis.

Xia T, Dong X, Jiang Y, Lin L, Dong Z, Shen Y, Xin H, Zhang Q, Qin L.

Molecules. 2019 Jan 11;24(2). pii: E253. doi: 10.3390/molecules24020253.


Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.

Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF.

Metabolism. 2019 Apr;93:1-9. doi: 10.1016/j.metabol.2018.12.003. Epub 2018 Dec 19.


11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Development by Lentiviral Screening Based on Computational Modeling.

Liu H, Li L, Zhang C, Li H, Liu J, Tang C, Zhang Y, Wu D, Chu Y, Wu Y, Yuan X.

Pharmacology. 2018;102(3-4):169-179. doi: 10.1159/000491397. Epub 2018 Aug 10.


Alterations of Cortisol Metabolism in Human Disorders.

White PC.

Horm Res Paediatr. 2018;89(5):320-330. doi: 10.1159/000485508. Epub 2018 May 29. Review.


A novel derivatives of thiazol-4(5H)-one and their activity in the inhibition of 11β-hydroxysteroid dehydrogenase type 1.

Studzińska R, Kołodziejska R, Kupczyk D, Płaziński W, Kosmalski T.

Bioorg Chem. 2018 Sep;79:115-121. doi: 10.1016/j.bioorg.2018.04.014. Epub 2018 Apr 30.


Dehydroepiandrosterone Antagonizes Pain Stress-Induced Suppression of Testosterone Production in Male Rats.

Zhu Q, Ge F, Li X, Deng HS, Xu M, Bu T, Li J, Wang Y, Shan Y, Ge RS, Yao M.

Front Pharmacol. 2018 Apr 16;9:322. doi: 10.3389/fphar.2018.00322. eCollection 2018.


Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series.

Daga PR, Bolger MB, Haworth IS, Clark RD, Martin EJ.

Mol Pharm. 2018 Mar 5;15(3):821-830. doi: 10.1021/acs.molpharmaceut.7b00972. Epub 2018 Feb 1.


11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z.

Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22.


Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice.

Cobice DF, Livingstone DEW, McBride A, MacKay CL, Walker BR, Webster SP, Andrew R.

Biochem Pharmacol. 2018 Feb;148:88-99. doi: 10.1016/j.bcp.2017.12.013. Epub 2017 Dec 15.


Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity.

DiNicolantonio JJ, Mehta V, Onkaramurthy N, O'Keefe JH.

Prog Cardiovasc Dis. 2018 May - Jun;61(1):3-9. doi: 10.1016/j.pcad.2017.12.001. Epub 2017 Dec 8. Review.


Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen.

Kang HY, Choi YK, Jeong YI, Choi KC, Hyun SH, Hwang WS, Jeung EB.

Int J Mol Sci. 2017 Dec 5;18(12). pii: E2625. doi: 10.3390/ijms18122625.


Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

Cheng Y, Wang L, Iacono L, Zhang D, Chen W, Gong J, Humphreys WG, Gan J.

Br J Clin Pharmacol. 2018 Jan;84(1):130-141. doi: 10.1111/bcp.13421. Epub 2017 Oct 4.


The cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome.

Loerz C, Maser E.

J Steroid Biochem Mol Biol. 2017 Nov;174:65-71. doi: 10.1016/j.jsbmb.2017.07.030. Epub 2017 Jul 29. Review.


Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs.

Vihma V, Naukkarinen J, Turpeinen U, Hämäläinen E, Kaprio J, Rissanen A, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Mikkola TS, Tikkanen MJ, Pietiläinen KH.

J Steroid Biochem Mol Biol. 2017 Sep;172:98-105. doi: 10.1016/j.jsbmb.2017.06.007. Epub 2017 Jun 13.


Dietary fat and gut microbiota interactions determine diet-induced obesity in mice.

Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M.

Mol Metab. 2016 Oct 13;5(12):1162-1174. doi: 10.1016/j.molmet.2016.10.001. eCollection 2016 Dec.


Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity.

Lutz SZ, Peter A, Machicao F, Lamprinou A, Machann J, Schick F, Königsrainer I, Königsrainer A, Fritsche A, Staiger H, Häring HU, Stefan N, Kantartzis K.

J Clin Endocrinol Metab. 2016 Dec;101(12):4743-4751. Epub 2016 Oct 7.


Safety, pharmacokinetics and pharmacodynamics of BI 135585, a selective 11β-hydroxysteroid dehydrogenase-1 (HSD1) inhibitor in humans: liver and adipose tissue 11β-HSD1 inhibition after acute and multiple administrations over 2 weeks.

Freude S, Heise T, Woerle HJ, Jungnik A, Rauch T, Hamilton B, Schölch C, Huang F, Graefe-Mody U.

Diabetes Obes Metab. 2016 May;18(5):483-90. doi: 10.1111/dom.12635. Epub 2016 Mar 10.


Butylated Hydroxyanisole Potently Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2.

Li L, Wu Y, Wu X, Wang H, Bai Y, Wang X, Akingbemi BT, Huang P, Ge RS.

Pharmacology. 2016;97(1-2):10-7. doi: 10.1159/000441034. Epub 2015 Nov 14.


Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells.

Li X, Hu G, Li X, Wang YY, Hu YY, Zhou H, Latif SA, Morris DJ, Chu Y, Zheng Z, Ge RS.

PLoS One. 2015 Nov 3;10(11):e0141767. doi: 10.1371/journal.pone.0141767. eCollection 2015.

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