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Items: 1 to 20 of 47


Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study.

Balendra R, Uphill J, Collinson C, Druyeh R, Adamson G, Hummerich H, Zerr I, Gambetti P, Collinge J, Mead S.

BMC Med Genet. 2016 Apr 7;17:28. doi: 10.1186/s12881-016-0278-2.


Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years.

Rudge P, Jaunmuktane Z, Adlard P, Bjurstrom N, Caine D, Lowe J, Norsworthy P, Hummerich H, Druyeh R, Wadsworth JD, Brandner S, Hyare H, Mead S, Collinge J.

Brain. 2015 Nov;138(Pt 11):3386-99. doi: 10.1093/brain/awv235.


Inherited mtDNA variations are not strong risk factors in human prion disease.

Hudson G, Uphill J, Hummerich H, Blevins J, Gambetti P, Zerr I, Collinge J, Mead S, Chinnery PF.

Neurobiol Aging. 2015 Oct;36(10):2908.e1-3. doi: 10.1016/j.neurobiolaging.2015.07.005.


Rare structural genetic variation in human prion diseases.

Lukic A, Uphill J, Brown CA, Beck J, Poulter M, Campbell T, Adamson G, Hummerich H, Whitfield J, Ponto C, Zerr I, Lloyd SE, Collinge J, Mead S.

Neurobiol Aging. 2015 May;36(5):2004.e1-8. doi: 10.1016/j.neurobiolaging.2015.01.011.


Exome sequencing of 75 individuals from multiply affected coeliac families and large scale resequencing follow up.

Mistry V, Bockett NA, Levine AP, Mirza MM, Hunt KA, Ciclitira PJ, Hummerich H, Neuhausen SL, Simpson MA, Plagnol V, van Heel DA.

PLoS One. 2015 Jan 30;10(1):e0116845. doi: 10.1371/journal.pone.0116845.


Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND.

PLoS Genet. 2014 Sep 25;10(9):e1004642. doi: 10.1371/journal.pgen.1004642.


Identification of a gene regulatory network associated with prion replication.

Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC.

EMBO J. 2014 Jul 17;33(14):1527-47. doi: 10.15252/embj.201387150.


In vitro screen of prion disease susceptibility genes using the scrapie cell assay.

Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE.

Hum Mol Genet. 2014 Oct 1;23(19):5102-8. doi: 10.1093/hmg/ddu233.


HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.

Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ.

Brain. 2014 Mar;137(Pt 3):819-33. doi: 10.1093/brain/awt355.


The costs of dementia from the societal perspective: is care provided in the community really cheaper than nursing home care?

König HH, Leicht H, Brettschneider C, Bachmann C, Bickel H, Fuchs A, Jessen F, Köhler M, Luppa M, Mösch E, Pentzek M, Werle J, Weyerer S, Wiese B, Scherer M, Maier W, Riedel-Heller SG; AgeCoDe Study Group..

J Am Med Dir Assoc. 2014 Feb;15(2):117-26. doi: 10.1016/j.jamda.2013.10.003.


Sod1 deficiency reduces incubation time in mouse models of prion disease.

Akhtar S, Grizenkova J, Wenborn A, Hummerich H, Fernandez de Marco M, Brandner S, Collinge J, Lloyd SE.

PLoS One. 2013;8(1):e54454. doi: 10.1371/journal.pone.0054454.


Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).

Heser K, Tebarth F, Wiese B, Eisele M, Bickel H, Köhler M, Mösch E, Weyerer S, Werle J, König HH, Leicht H, Pentzek M, Fuchs A, Riedel-Heller SG, Luppa M, Prokein J, Scherer M, Maier W, Wagner M; Age CoDe Study Group..

Psychol Med. 2013 Aug;43(8):1597-610. doi: 10.1017/S0033291712002449.


Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13722-7. doi: 10.1073/pnas.1208917109.


Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases.

Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H.

Neurology. 2012 Jul 10;79(2):127-31. doi: 10.1212/WNL.0b013e31825f048e.


Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe.

Eisele M, Zimmermann T, Köhler M, Wiese B, Heser K, Tebarth F, Weeg D, Olbrich J, Pentzek M, Fuchs A, Weyerer S, Werle J, Leicht H, König HH, Luppa M, Riedel-Heller S, Maier W, Scherer M; AgeCoDe Study Group..

BMC Geriatr. 2012 Mar 20;12:9. doi: 10.1186/1471-2318-12-9.


Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.

Castro-Seoane R, Hummerich H, Sweeting T, Tattum MH, Linehan JM, Fernandez de Marco M, Brandner S, Collinge J, Klöhn PC.

PLoS Pathog. 2012 Feb;8(2):e1002538. doi: 10.1371/journal.ppat.1002538.


Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.

Mead S, Uphill J, Beck J, Poulter M, Campbell T, Lowe J, Adamson G, Hummerich H, Klopp N, Rückert IM, Wichmann HE, Azazi D, Plagnol V, Pako WH, Whitfield J, Alpers MP, Whittaker J, Balding DJ, Zerr I, Kretzschmar H, Collinge J.

Hum Mol Genet. 2012 Apr 15;21(8):1897-906. doi: 10.1093/hmg/ddr607.


Prediction of dementia in primary care patients.

Jessen F, Wiese B, Bickel H, Eiffländer-Gorfer S, Fuchs A, Kaduszkiewicz H, Köhler M, Luck T, Mösch E, Pentzek M, Riedel-Heller SG, Wagner M, Weyerer S, Maier W, van den Bussche H; AgeCoDe Study Group..

PLoS One. 2011 Feb 18;6(2):e16852. doi: 10.1371/journal.pone.0016852.


Activation of nuclear factor-kappa B signalling promotes cellular senescence.

Rovillain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema RH, Hummerich H, Jat PS.

Oncogene. 2011 May 19;30(20):2356-66. doi: 10.1038/onc.2010.611.


A novel protective prion protein variant that colocalizes with kuru exposure.

Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Dujaily H, Hummerich H, Beck J, Mein CA, Verzilli C, Whittaker J, Alpers MP, Collinge J.

N Engl J Med. 2009 Nov 19;361(21):2056-65. doi: 10.1056/NEJMoa0809716.

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