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Items: 1 to 20 of 93


Iron accumulation promotes TACE-mediated TNF-α secretion and neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Gwag BJ, Choi EJ.

Neurobiol Dis. 2015 Aug;80:63-9. doi: 10.1016/j.nbd.2015.05.009. Epub 2015 May 20.


MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12066-71. doi: 10.1073/pnas.1300894110. Epub 2013 Jul 1.


AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease.

Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL.

Exp Neurobiol. 2013 Mar;22(1):31-7. doi: 10.5607/en.2013.22.1.31. Epub 2013 Mar 31.


Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage.

Visavadiya NP, McEwen ML, Pandya JD, Sullivan PG, Gwag BJ, Springer JE.

Toxicol In Vitro. 2013 Mar;27(2):788-97. doi: 10.1016/j.tiv.2012.12.011. Epub 2012 Dec 23.


Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis.

Lee JH, An CS, Yun BS, Kang KS, Lee YA, Won SM, Gwag BJ, Cho SI, Hahm KB.

Eur J Pharmacol. 2012 Jul 15;687(1-3):28-38. doi: 10.1016/j.ejphar.2012.04.048. Epub 2012 May 3.


Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.

Shin JH, Lee YA, Lee JK, Lee YB, Cho W, Im DS, Lee JH, Yun BS, Springer JE, Gwag BJ.

J Neurochem. 2012 Sep;122(5):952-61. doi: 10.1111/j.1471-4159.2012.07771.x. Epub 2012 May 23.


Role of the NMDA receptor and iron on free radical production and brain damage following transient middle cerebral artery occlusion.

Im DS, Jeon JW, Lee JS, Won SJ, Cho SI, Lee YB, Gwag BJ.

Brain Res. 2012 May 21;1455:114-23. doi: 10.1016/j.brainres.2012.03.025. Epub 2012 Mar 17.


Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice.

Park SM, Shin JH, Moon GJ, Cho SI, Lee YB, Gwag BJ.

BMC Neurosci. 2011 Oct 27;12:106. doi: 10.1186/1471-2202-12-106.


Identification of oxidized serum albumin in the cerebrospinal fluid of ischaemic stroke patients.

Moon GJ, Shin DH, Im DS, Bang OY, Nam HS, Lee JH, Joo IS, Huh K, Gwag BJ.

Eur J Neurol. 2011 Sep;18(9):1151-8. doi: 10.1111/j.1468-1331.2011.03357.x. Epub 2011 Feb 8.


Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke.

Cho SI, Park UJ, Chung JM, Gwag BJ.

Drug News Perspect. 2010 Nov;23(9):549-56. doi: 10.1358/dnp.2010.23.9.1513493. Review.


Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: an additional contributing factor of cognitive impairment.

Lee JS, Im DS, An YS, Hong JM, Gwag BJ, Joo IS.

Neurosci Lett. 2011 Feb 4;489(2):84-8. doi: 10.1016/j.neulet.2010.11.071. Epub 2010 Dec 4.


Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat.

Park UJ, Lee YA, Won SM, Lee JH, Kang SH, Springer JE, Lee YB, Gwag BJ.

Acta Neuropathol. 2011 Apr;121(4):459-73. doi: 10.1007/s00401-010-0785-8. Epub 2010 Dec 1.


Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.

Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ.

J Neurochem. 2010 Jul;114(1):160-70. doi: 10.1111/j.1471-4159.2010.06732.x. Epub 2010 Apr 3.


Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.

Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ.

Exp Mol Med. 2010 May 31;42(5):386-94.


Influence of recanalization on uric acid patterns in acute ischemic stroke.

Hong JM, Bang OY, Chung CS, Joo IS, Gwag BJ, Ovbiagele B.

Cerebrovasc Dis. 2010;29(5):431-9. doi: 10.1159/000289346. Epub 2010 Mar 4.


The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury.

Springer JE, Rao RR, Lim HR, Cho SI, Moon GJ, Lee HY, Park EJ, Noh JS, Gwag BJ.

J Neurotrauma. 2010 Jan;27(1):139-49. doi: 10.1089/neu.2009.0952. Erratum in: J Neurotrauma. 2010 Mar;27(3):653.


Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice.

Kim J, Kim TY, Hwang JJ, Lee JY, Shin JH, Gwag BJ, Koh JY.

Neurobiol Dis. 2009 May;34(2):221-9. doi: 10.1016/j.nbd.2009.01.004. Epub 2009 Jan 21.


Update of the stroke therapy academic industry roundtable preclinical recommendations.

Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH; STAIR Group.

Stroke. 2009 Jun;40(6):2244-50. doi: 10.1161/STROKEAHA.108.541128. Epub 2009 Feb 26. Review.

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