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Items: 1 to 20 of 133


Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.

Sci Rep. 2017 Feb 23;7:43135. doi: 10.1038/srep43135.


Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.

Cell Chem Biol. 2016 Aug 18;23(8):1023-35. doi: 10.1016/j.chembiol.2016.05.020. Epub 2016 Jul 28.


Protease signaling in animal and plant-regulated cell death.

Salvesen GS, Hempel A, Coll NS.

FEBS J. 2016 Jul;283(14):2577-98. doi: 10.1111/febs.13616. Epub 2015 Dec 31. Review.


Small Molecule Active Site Directed Tools for Studying Human Caspases.

Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M.

Chem Rev. 2015 Nov 25;115(22):12546-629. doi: 10.1021/acs.chemrev.5b00434. Epub 2015 Nov 9. Review.


The Paracaspase MALT1.

Hachmann J, Salvesen GS.

Biochimie. 2016 Mar;122:324-38. doi: 10.1016/j.biochi.2015.09.018. Epub 2015 Sep 16. Review.


Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.

Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16.


Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.

Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M.

PLoS One. 2015 Jul 14;10(7):e0132818. doi: 10.1371/journal.pone.0132818. eCollection 2015.


SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.

Fasci D, Anania VG, Lill JR, Salvesen GS.

Sci Signal. 2015 Jun 9;8(380):ra56. doi: 10.1126/scisignal.aaa3929.


Probes to monitor activity of the paracaspase MALT1.

Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS.

Chem Biol. 2015 Jan 22;22(1):139-47. doi: 10.1016/j.chembiol.2014.11.011. Epub 2014 Dec 31.


Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.

Kumar S, van Raam BJ, Salvesen GS, Cieplak P.

PLoS One. 2014 Oct 17;9(10):e110539. doi: 10.1371/journal.pone.0110539. eCollection 2014.


Caspase enzymology and activation mechanisms.

Mace PD, Riedl SJ, Salvesen GS.

Methods Enzymol. 2014;544:161-78. doi: 10.1016/B978-0-12-417158-9.00007-8.


Functions of caspase 8: the identified and the mysterious.

Salvesen GS, Walsh CM.

Semin Immunol. 2014 Jun;26(3):246-52. doi: 10.1016/j.smim.2014.03.005. Epub 2014 May 21. Review.


Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.

Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G.

J Biol Chem. 2014 May 30;289(22):15544-53. doi: 10.1074/jbc.M113.507616. Epub 2014 Apr 8.


A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.

Byzia A, Haeggström JZ, Salvesen GS, Drag M.

Amino Acids. 2014 May;46(5):1313-20. doi: 10.1007/s00726-014-1694-2. Epub 2014 Feb 27.


Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.

Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23. doi: 10.1073/pnas.1318548111. Epub 2014 Feb 3.


Caspase substrates and inhibitors.

Poreba M, Strózyk A, Salvesen GS, Drag M.

Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. doi: 10.1101/cshperspect.a008680. Review.


Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.

ACS Chem Biol. 2013 Apr 19;8(4):725-32. doi: 10.1021/cb3005512. Epub 2013 Feb 5.


Activity, specificity, and probe design for the smallpox virus protease K7L.

Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.

J Biol Chem. 2012 Nov 16;287(47):39470-9. doi: 10.1074/jbc.M112.388678. Epub 2012 Sep 25.


Highlight: the universe of proteolytic networks and mechanisms.

Salvesen GS, Bogyo M.

Biol Chem. 2012 Sep;393(9):841. doi: 10.1515/hsz-2012-0262. No abstract available.


Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.

Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU.

J Biol Chem. 2012 Jun 15;287(25):21142-51. doi: 10.1074/jbc.M111.306399. Epub 2012 Apr 23.

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