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Items: 1 to 20 of 64


Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection.

Noh H, Shoemaker JE, Gunawan R.

Nucleic Acids Res. 2018 Jan 9. doi: 10.1093/nar/gkx1314. [Epub ahead of print]


Diagnostic value of 99mTc-ethambutol scintigraphy in tuberculosis: compared to microbiological and histopathological tests.

Kartamihardja AHS, Kurniawati Y, Gunawan R.

Ann Nucl Med. 2018 Jan;32(1):60-68. doi: 10.1007/s12149-017-1220-1. Epub 2017 Dec 5.


Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing.

Kyriakopoulos S, Ang KS, Lakshmanan M, Huang Z, Yoon S, Gunawan R, Lee DY.

Biotechnol J. 2018 Mar;13(3):e1700229. doi: 10.1002/biot.201700229. Epub 2017 Nov 14. Review.


SINCERITIES: Inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles.

Papili Gao N, Ud-Dean SMM, Gandrillon O, Gunawan R.

Bioinformatics. 2017 Sep 14. doi: 10.1093/bioinformatics/btx575. [Epub ahead of print]


Assessing and Resolving Model Misspecifications in Metabolic Flux Analysis.

Gunawan R, Hutter S.

Bioengineering (Basel). 2017 May 24;4(2). pii: E48. doi: 10.3390/bioengineering4020048.


Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures.

Hutter S, Villiger TK, Brühlmann D, Stettler M, Broly H, Soos M, Gunawan R.

Metab Eng. 2017 Sep;43(Pt A):9-20. doi: 10.1016/j.ymben.2017.07.005. Epub 2017 Jul 25.


Population Pharmacokinetics of Nusinersen in the Cerebral Spinal Fluid and Plasma of Pediatric Patients With Spinal Muscular Atrophy Following Intrathecal Administrations.

Luu KT, Norris DA, Gunawan R, Henry S, Geary R, Wang Y.

J Clin Pharmacol. 2017 Aug;57(8):1031-1041. doi: 10.1002/jcph.884. Epub 2017 Mar 29.


Bioprocess optimization under uncertainty using ensemble modeling.

Liu Y, Gunawan R.

J Biotechnol. 2017 Feb 20;244:34-44. doi: 10.1016/j.jbiotec.2017.01.013. Epub 2017 Jan 27.


Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process.

Richard A, Boullu L, Herbach U, Bonnafoux A, Morin V, Vallin E, Guillemin A, Papili Gao N, Gunawan R, Cosette J, Arnaud O, Kupiec JJ, Espinasse T, Gonin-Giraud S, Gandrillon O.

PLoS Biol. 2016 Dec 27;14(12):e1002585. doi: 10.1371/journal.pbio.1002585. eCollection 2016 Dec.


Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y.

Nucleic Acid Ther. 2016 Dec;26(6):372-380. Epub 2016 Aug 8.


TRaCE+: Ensemble inference of gene regulatory networks from transcriptional expression profiles of gene knock-out experiments.

Ud-Dean SM, Heise S, Klamt S, Gunawan R.

BMC Bioinformatics. 2016 Jun 24;17:252. doi: 10.1186/s12859-016-1137-z.


Inferring gene targets of drugs and chemical compounds from gene expression profiles.

Noh H, Gunawan R.

Bioinformatics. 2016 Jul 15;32(14):2120-7. doi: 10.1093/bioinformatics/btw148. Epub 2016 Mar 18.


Comparative pharmacokinetics, safety, and tolerability of two sources of ch14.18 in pediatric patients with high-risk neuroblastoma following myeloablative therapy.

Marachelian A, Desai A, Balis F, Katzenstein H, Qayed M, Armstrong M, Neville KA, Cohn SL, Bush M, Gunawan R, Lim AP, Smith MA, Smith LM.

Cancer Chemother Pharmacol. 2016 Feb;77(2):405-12. doi: 10.1007/s00280-015-2955-9. Epub 2016 Jan 20.


No effect on QT intervals of mipomersen, a 2'-O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects.

Yu RZ, Gunawan R, Li Z, Mittleman RS, Mahmood A, Grundy JS, Singleton W, Geary R, Wang Y.

Eur J Clin Pharmacol. 2016 Mar;72(3):267-75. doi: 10.1007/s00228-015-1992-y. Epub 2015 Dec 9.


Optimal design of gene knockout experiments for gene regulatory network inference.

Ud-Dean SM, Gunawan R.

Bioinformatics. 2016 Mar 15;32(6):875-83. doi: 10.1093/bioinformatics/btv672. Epub 2015 Nov 14.


Using dynamic sensitivities to characterize metabolic reaction systems.

Sriyudthsak K, Uno H, Gunawan R, Shiraishi F.

Math Biosci. 2015 Nov;269:153-63. doi: 10.1016/j.mbs.2015.09.002. Epub 2015 Sep 16.


REDEMPTION: reduced dimension ensemble modeling and parameter estimation.

Liu Y, Manesso E, Gunawan R.

Bioinformatics. 2015 Oct 15;31(20):3387-9. doi: 10.1093/bioinformatics/btv365. Epub 2015 Jun 14.


Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations.

Tam ZY, Gruber J, Halliwell B, Gunawan R.

PLoS Comput Biol. 2015 May 21;11(5):e1004183. doi: 10.1371/journal.pcbi.1004183. eCollection 2015 May.


Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

Lakshmanan LN, Gruber J, Halliwell B, Gunawan R.

Nucleic Acids Res. 2015 Apr 30;43(8):4098-108. doi: 10.1093/nar/gkv299. Epub 2015 Apr 8.

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