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Items: 1 to 20 of 141


Radium-223 mechanism of action: implications for use in treatment combinations.

Morris MJ, Corey E, Guise TA, Gulley JL, Kevin Kelly W, Quinn DI, Scholz A, Sgouros G.

Nat Rev Urol. 2019 Dec;16(12):745-756. doi: 10.1038/s41585-019-0251-x. Epub 2019 Nov 11. Review.


TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.

Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long CL, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmäki H, Hesse E.

Nat Commun. 2019 Mar 22;10(1):1354. doi: 10.1038/s41467-019-08778-x.


Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity.

Pagnotti GM, Styner M, Uzer G, Patel VS, Wright LE, Ness KK, Guise TA, Rubin J, Rubin CT.

Nat Rev Endocrinol. 2019 Jun;15(6):339-355. doi: 10.1038/s41574-019-0170-1. Review.


A "Connexin" Responsible for the Fatal Attraction of Cancer to Bone.

Waning DL, Guise TA, Mohammad KS.

Cell Metab. 2019 Jan 8;29(1):6-8. doi: 10.1016/j.cmet.2018.12.014.


Alkaline phosphatase in metastatic castration-resistant prostate cancer: reassessment of an older biomarker.

Heinrich D, Bruland Ø, Guise TA, Suzuki H, Sartor O.

Future Oncol. 2018 Oct;14(24):2543-2556. doi: 10.2217/fon-2018-0087. Epub 2018 Jun 21. Review.


Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model.

Regan JN, Mikesell C, Reiken S, Xu H, Marks AR, Mohammad KS, Guise TA, Waning DL.

Front Endocrinol (Lausanne). 2017 Dec 19;8:358. doi: 10.3389/fendo.2017.00358. eCollection 2017.


Breaking Down Barriers to Chemoresistance: Role of Chemotherapy-Induced Osteoblastic Jagged1.

Mohammad KS, Guise TA.

Cancer Cell. 2017 Dec 11;32(6):717-718. doi: 10.1016/j.ccell.2017.11.016.


Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis.

Juárez P, Fournier PGJ, Mohammad KS, McKenna RC, Davis HW, Peng XH, Niewolna M, Mauviel A, Chirgwin JM, Guise TA.

Oncotarget. 2017 Sep 23;8(49):86447-86462. doi: 10.18632/oncotarget.21200. eCollection 2017 Oct 17.


Neuropeptide Y regulates a vascular gateway for hematopoietic stem and progenitor cells.

Singh P, Hoggatt J, Kamocka MM, Mohammad KS, Saunders MR, Li H, Speth J, Carlesso N, Guise TA, Pelus LM.

J Clin Invest. 2017 Dec 1;127(12):4527-4540. doi: 10.1172/JCI94687. Epub 2017 Nov 13.


Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases.

Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack DV, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack J, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN.

Cancer Res. 2017 Nov 15;77(22):6299-6312. doi: 10.1158/0008-5472.CAN-17-1225. Epub 2017 Aug 30.


The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm.

Trivedi T, Zheng Y, Fournier PGJ, Murthy S, John S, Schillo S, Dunstan CR, Mohammad KS, Zhou H, Seibel MJ, Guise TA.

Oncotarget. 2017 Apr 18;8(16):26687-26701. doi: 10.18632/oncotarget.15803.


The Role of TGFβ in Bone-Muscle Crosstalk.

Regan JN, Trivedi T, Guise TA, Waning DL.

Curr Osteoporos Rep. 2017 Feb;15(1):18-23. doi: 10.1007/s11914-017-0344-5. Review.


Differential Bone Loss in Mouse Models of Colon Cancer Cachexia.

Bonetto A, Kays JK, Parker VA, Matthews RR, Barreto R, Puppa MJ, Kang KS, Carson JA, Guise TA, Mohammad KS, Robling AG, Couch ME, Koniaris LG, Zimmers TA.

Front Physiol. 2017 Jan 11;7:679. doi: 10.3389/fphys.2016.00679. eCollection 2016.


Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo.

Wright LE, Harhash AA, Kozlow WM, Waning DL, Regan JN, She Y, John SK, Murthy S, Niewolna M, Marks AR, Mohammad KS, Guise TA.

Oncotarget. 2017 Jan 31;8(5):8406-8419. doi: 10.18632/oncotarget.14139.


Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.

Zhang P, Xing C, Rhodes SD, He Y, Deng K, Li Z, He F, Zhu C, Nguyen L, Zhou Y, Chen S, Mohammad KS, Guise TA, Abdel-Wahab O, Xu M, Wang QF, Yang FC.

Stem Cell Reports. 2016 Jun 14;6(6):914-925. doi: 10.1016/j.stemcr.2016.04.013. Epub 2016 May 26.


Hypercalcemia of Malignancy: A New Twist on an Old Problem.

Mohammad KS, Guise TA.

J Oncol Pract. 2016 May;12(5):435-6. doi: 10.1200/JOP.2016.012062. No abstract available.


Skeletal muscle Ca(2+) mishandling: Another effect of bone-to-muscle signaling.

Regan JN, Waning DL, Guise TA.

Semin Cell Dev Biol. 2016 Jan;49:24-9. doi: 10.1016/j.semcdb.2015.11.007. Epub 2015 Nov 24. Review.


Calcium release channel RyR2 regulates insulin release and glucose homeostasis.

Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR.

J Clin Invest. 2015 Nov 2;125(11):4316. doi: 10.1172/JCI84937. Epub 2015 Nov 2. No abstract available.


Excess TGF-β mediates muscle weakness associated with bone metastases in mice.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA.

Nat Med. 2015 Nov;21(11):1262-1271. doi: 10.1038/nm.3961. Epub 2015 Oct 12.


Elevated incidence of fractures in women with invasive breast cancer.

Edwards BJ, Gradishar WJ, Smith ME, Pacheco JA, Holbrook J, McKoy JM, Nardone B, Tica S, Godinez-Puig V, Rademaker AW, Helenowski IB, Bunta AD, Stern PH, Rosen ST, West DP, Guise TA.

Osteoporos Int. 2016 Feb;27(2):499-507. doi: 10.1007/s00198-015-3246-3. Epub 2015 Aug 21.


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