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Items: 1 to 20 of 156

1.

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy.

Llano-Diez M, Fury W, Okamoto H, Bai Y, Gromada J, Larsson L.

Skelet Muscle. 2019 Apr 16;9(1):9. doi: 10.1186/s13395-019-0194-1.

2.

Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition.

Kim J, Dominguez Gutierrez G, Xin Y, Cavino K, Sung B, Sipos B, Kloeppel G, Gromada J, Okamoto H.

Endocrinology. 2019 May 1;160(5):979-988. doi: 10.1210/en.2019-00022.

PMID:
30938753
3.

The liver-alpha cell axis and type 2 diabetes.

Wewer Albrechtsen NJ, Pedersen J, Galsgaard KD, Winther-Sørensen M, Suppli MP, Janah L, Gromada J, Vilstrup H, Knop FK, Holst JJ.

Endocr Rev. 2019 Mar 28. pii: er.2018-00251. doi: 10.1210/er.2018-00251. [Epub ahead of print]

PMID:
30920583
4.

Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol.

Spolitu S, Okamoto H, Dai W, Zadroga JA, Wittchen ES, Gromada J, Ozcan L.

Circ Res. 2019 Jan 4;124(1):38-51. doi: 10.1161/CIRCRESAHA.118.313648.

PMID:
30582457
5.

Gene Signature of the Human Pancreatic ε Cell.

Dominguez Gutierrez G, Kim J, Lee AH, Tong J, Niu J, Gray SM, Wei Y, Ding Y, Ni M, Adler C, Murphy AJ, Gromada J, Xin Y.

Endocrinology. 2018 Dec 1;159(12):4023-4032. doi: 10.1210/en.2018-00833.

PMID:
30380031
6.

Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).

Liddie S, Okamoto H, Gromada J, Lawrence M.

J Med Primatol. 2019 Feb;48(1):10-21. doi: 10.1111/jmp.12374. Epub 2018 Oct 25.

PMID:
30357856
7.

The α-cell in diabetes mellitus.

Gromada J, Chabosseau P, Rutter GA.

Nat Rev Endocrinol. 2018 Dec;14(12):694-704. doi: 10.1038/s41574-018-0097-y. Review.

PMID:
30310153
8.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23.

9.

Gene Signature of Proliferating Human Pancreatic α Cells.

Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee AH, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J.

Endocrinology. 2018 Sep 1;159(9):3177-3186. doi: 10.1210/en.2018-00469.

PMID:
30010845
10.

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response.

Xin Y, Dominguez Gutierrez G, Okamoto H, Kim J, Lee AH, Adler C, Ni M, Yancopoulos GD, Murphy AJ, Gromada J.

Diabetes. 2018 Sep;67(9):1783-1794. doi: 10.2337/db18-0365. Epub 2018 Jun 27.

11.

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, Scott RA, Lee WJ, Small A, Kwee LC, Dwivedi OP, Prasad RB, Bruse S, Lopez AE, Penn J, Marcketta A, Leader JB, Still CD, Kirchner HL, Mirshahi UL, Wardeh AH, Hartle CM, Habegger L, Fetterolf SN, Tusie-Luna T, Morris AP, Holm H, Steinthorsdottir V, Sulem P, Thorsteinsdottir U, Rotter JI, Chuang LM, Damrauer S, Birtwell D, Brummett CM, Khera AV, Natarajan P, Orho-Melander M, Flannick J, Lotta LA, Willer CJ, Holmen OL, Ritchie MD, Ledbetter DH, Murphy AJ, Borecki IB, Reid JG, Overton JD, Hansson O, Groop L, Shah SH, Kraus WE, Rader DJ, Chen YI, Hveem K, Wareham NJ, Kathiresan S, Melander O, Stefansson K, Nordestgaard BG, Tybjærg-Hansen A, Abecasis GR, Altshuler D, Florez JC, Boehnke M, McCarthy MI, Yancopoulos GD, Carey DJ, Shuldiner AR, Baras A, Dewey FE, Gromada J.

Nat Commun. 2018 Jun 13;9(1):2252. doi: 10.1038/s41467-018-04611-z.

12.

Corrigendum to 'Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells' [Cellular Signalling 46 (2018) 120-128].

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, de Souza Ferreira S, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2019 Jan;53:415. doi: 10.1016/j.cellsig.2018.05.004. Epub 2018 May 25. No abstract available.

13.

Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.

Xu X, Krumm C, So JS, Bare CJ, Holman C, Gromada J, Cohen DE, Lee AH.

Hepatology. 2018 Dec;68(6):2167-2181. doi: 10.1002/hep.30060. Epub 2018 Nov 5.

PMID:
29698569
14.

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, Balasubramanian S, Gosalia N, Esopi D, Kim SY, Mukherjee S, Lopez AE, Fuller ED, Penn J, Chu X, Luo JZ, Mirshahi UL, Carey DJ, Still CD, Feldman MD, Small A, Damrauer SM, Rader DJ, Zambrowicz B, Olson W, Murphy AJ, Borecki IB, Shuldiner AR, Reid JG, Overton JD, Yancopoulos GD, Hobbs HH, Cohen JC, Gottesman O, Teslovich TM, Baras A, Mirshahi T, Gromada J, Dewey FE.

N Engl J Med. 2018 Mar 22;378(12):1096-1106. doi: 10.1056/NEJMoa1712191.

15.

Glucagon contributes to liver zonation.

Cheng X, Kim SY, Okamoto H, Xin Y, Yancopoulos GD, Murphy AJ, Gromada J.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4111-E4119. doi: 10.1073/pnas.1721403115. Epub 2018 Mar 19.

16.

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2018 Jun;46:120-128. doi: 10.1016/j.cellsig.2018.03.001. Epub 2018 Mar 6. Erratum in: Cell Signal. 2019 Jan;53:415.

17.

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice.

Banfi S, Gusarova V, Gromada J, Cohen JC, Hobbs HH.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1249-E1258. doi: 10.1073/pnas.1717420115. Epub 2018 Jan 22.

18.

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30.

PMID:
29032602
19.

A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers.

Kostic A, King TA, Yang F, Chan KC, Yancopoulos GD, Gromada J, Harp JB.

Diabetes Obes Metab. 2018 Feb;20(2):283-291. doi: 10.1111/dom.13075. Epub 2017 Sep 14.

20.

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia.

Gaudet D, Gipe DA, Pordy R, Ahmad Z, Cuchel M, Shah PK, Chyu KY, Sasiela WJ, Chan KC, Brisson D, Khoury E, Banerjee P, Gusarova V, Gromada J, Stahl N, Yancopoulos GD, Hovingh GK.

N Engl J Med. 2017 Jul 20;377(3):296-297. doi: 10.1056/NEJMc1705994. No abstract available.

PMID:
28723334

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