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Items: 1 to 20 of 41


Translational attenuation and retinal degeneration in mice with an active integrated stress response.

Starr CR, Pitale PM, Gorbatyuk M.

Cell Death Dis. 2018 May 1;9(5):484. doi: 10.1038/s41419-018-0513-1.


Neurodegeneration: Keeping ATF4 on a Tight Leash.

Pitale PM, Gorbatyuk O, Gorbatyuk M.

Front Cell Neurosci. 2017 Dec 15;11:410. doi: 10.3389/fncel.2017.00410. eCollection 2017. Review.


TNFa knockdown in the retina promotes cone survival in a mouse model of autosomal dominant retinitis pigmentosa.

Rana T, Kotla P, Fullard R, Gorbatyuk M.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):92-102. doi: 10.1016/j.bbadis.2016.10.008. Epub 2016 Nov 14.


ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.

Srivastava RK, Li C, Ahmad A, Abrams O, Gorbatyuk MS, Harrod KS, Wek RC, Afaq F, Athar M.

Arch Biochem Biophys. 2016 Nov 1;609:39-50. doi: 10.1016/ Epub 2016 Sep 13.


Neuronatin Protein in Health and Disease.

Pitale PM, Howse W, Gorbatyuk M.

J Cell Physiol. 2017 Mar;232(3):477-481. doi: 10.1002/jcp.25498. Epub 2016 Jul 27. Review.


Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.

Gully JC, Sergeyev VG, Bhootada Y, Mendez-Gomez H, Meyers CA, Zolotukhin S, Gorbatyuk MS, Gorbatyuk OS.

Neurosci Lett. 2016 Aug 3;627:36-41. doi: 10.1016/j.neulet.2016.05.039. Epub 2016 May 24.


Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.

Bhootada Y, Kotla P, Zolotukhin S, Gorbatyuk O, Bebok Z, Athar M, Gorbatyuk M.

PLoS One. 2016 May 4;11(5):e0154779. doi: 10.1371/journal.pone.0154779. eCollection 2016.


Neuronatin is a stress-responsive protein of rod photoreceptors.

Shinde V, Pitale PM, Howse W, Gorbatyuk O, Gorbatyuk M.

Neuroscience. 2016 Jul 22;328:1-8. doi: 10.1016/j.neuroscience.2016.04.023. Epub 2016 Apr 21.


Unfolded protein response is activated in aged retinas.

Lenox AR, Bhootada Y, Gorbatyuk O, Fullard R, Gorbatyuk M.

Neurosci Lett. 2015 Nov 16;609:30-5. doi: 10.1016/j.neulet.2015.10.019. Epub 2015 Oct 17.


Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.

Chiang WC, Joseph V, Yasumura D, Matthes MT, Lewin AS, Gorbatyuk MS, Ahern K, LaVail MM, Lin JH.

Adv Exp Med Biol. 2016;854:185-91. doi: 10.1007/978-3-319-17121-0_25.


Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.

Bhootada Y, Choudhury S, Gully C, Gorbatyuk M.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4725-33. doi: 10.1167/iovs.15-16924.


The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.

Salganik M, Sergeyev VG, Shinde V, Meyers CA, Gorbatyuk MS, Lin JH, Zolotukhin S, Gorbatyuk OS.

Neurobiol Aging. 2015 Jun;36(6):2213-23. doi: 10.1016/j.neurobiolaging.2015.02.018. Epub 2015 Mar 5.


Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs.

Murray AR, Vuong L, Brobst D, Fliesler SJ, Peachey NS, Gorbatyuk MS, Naash MI, Al-Ubaidi MR.

Hum Mol Genet. 2015 May 15;24(10):2709-23. doi: 10.1093/hmg/ddv031. Epub 2015 Jan 30.


An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina.

Rana T, Shinde VM, Starr CR, Kruglov AA, Boitet ER, Kotla P, Zolotukhin S, Gross AK, Gorbatyuk MS.

Cell Death Dis. 2014 Dec 18;5:e1578. doi: 10.1038/cddis.2014.539.


Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.

Choudhury S, Nashine S, Bhootada Y, Kunte MM, Gorbatyuk O, Lewin AS, Gorbatyuk M.

Adv Exp Med Biol. 2014;801:455-62. doi: 10.1007/978-1-4614-3209-8_58.


Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors.

Sizova OS, Shinde VM, Lenox AR, Gorbatyuk MS.

Cell Signal. 2014 Apr;26(4):665-672. doi: 10.1016/j.cellsig.2013.12.008. Epub 2013 Dec 27.


Review: retinal degeneration: focus on the unfolded protein response.

Gorbatyuk M, Gorbatyuk O.

Mol Vis. 2013 Sep 20;19:1985-98. eCollection 2013. Review.


Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].

Wang X, Wang G, Kunte M, Shinde V, Gorbatyuk M.

Invest Ophthalmol Vis Sci. 2013 Sep 3;54(9):5995-6002. doi: 10.1167/iovs.13-12117. Erratum in: Invest Ophthalmol Vis Sci. 2014 Mar;55(3):1310.


The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.

Gorbatyuk MS, Gorbatyuk OS.

J Genet Syndr Gene Ther. 2013 Mar 11;4(2). pii: 128.

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