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Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.

van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella TW Jr, Goedhart J.

Mol Pharmacol. 2016 Sep;90(3):162-76. doi: 10.1124/mol.116.104505. Epub 2016 Jun 29. Erratum in: Mol Pharmacol. 2016 Sep;90(3):413.


Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells.

Reinhard NR, van Helden SF, Anthony EC, Yin T, Wu YI, Goedhart J, Gadella TW, Hordijk PL.

Sci Rep. 2016 May 5;6:25502. doi: 10.1038/srep25502.


siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

Raspe M, Kedziora KM, van den Broek B, Zhao Q, de Jong S, Herz J, Mastop M, Goedhart J, Gadella TW, Young IT, Jalink K.

Nat Methods. 2016 Jun;13(6):501-4. doi: 10.1038/nmeth.3836. Epub 2016 Apr 18.


F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.

Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD.

Nat Commun. 2016 Jan 27;7:10493. doi: 10.1038/ncomms10493.


A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells.

van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW Jr, Goedhart J.

PLoS One. 2016 Jan 22;11(1):e0146789. doi: 10.1371/journal.pone.0146789. eCollection 2016.


Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.

van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J.

Sci Rep. 2015 Oct 5;5:14693. doi: 10.1038/srep14693.


SCARECROW-LIKE23 and SCARECROW jointly specify endodermal cell fate but distinctly control SHORT-ROOT movement.

Long Y, Goedhart J, Schneijderberg M, Terpstra I, Shimotohno A, Bouchet BP, Akhmanova A, Gadella TW Jr, Heidstra R, Scheres B, Blilou I.

Plant J. 2015 Nov;84(4):773-84. doi: 10.1111/tpj.13038.


A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.

J Cell Sci. 2015 Sep 15;128(18):3514. doi: 10.1242/jcs.179424. No abstract available.


Domain analysis of the Nematostella vectensis SNAIL ortholog reveals unique nucleolar localization that depends on the zinc-finger domains.

Dattoli AA, Hink MA, DuBuc TQ, Teunisse BJ, Goedhart J, Röttinger E, Postma M.

Sci Rep. 2015 Jul 20;5:12147. doi: 10.1038/srep12147.


A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.

J Cell Sci. 2015 Aug 15;128(16):3041-54. doi: 10.1242/jcs.168674. Epub 2015 Jun 26. Erratum in: J Cell Sci. 2015 Sep 15;128(18):3514.


A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.

van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ.

Mol Pharmacol. 2015 Sep;88(3):589-95. doi: 10.1124/mol.115.098897. Epub 2015 May 13. Review.


Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity.

Klarenbeek J, Goedhart J, van Batenburg A, Groenewald D, Jalink K.

PLoS One. 2015 Apr 14;10(4):e0122513. doi: 10.1371/journal.pone.0122513. eCollection 2015.


Effect of fixation procedures on the fluorescence lifetimes of Aequorea victoria derived fluorescent proteins.

Joosen L, Hink MA, Gadella TW Jr, Goedhart J.

J Microsc. 2014 Dec;256(3):166-76. doi: 10.1111/jmi.12168. Epub 2014 Sep 1.


Development of FRET biosensors for mammalian and plant systems.

Hamers D, van Voorst Vader L, Borst JW, Goedhart J.

Protoplasma. 2014 Mar;251(2):333-47. doi: 10.1007/s00709-013-0590-z. Epub 2013 Dec 12. Review.


SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.

Jezierska J, Goedhart J, Kampinga HH, Reits EA, Verbeek DS.

J Neurochem. 2014 Mar;128(5):741-51. doi: 10.1111/jnc.12491. Epub 2013 Nov 13.


Optimization of fluorescent proteins.

Bindels DS, Goedhart J, Hink MA, van Weeren L, Joosen L, Gadella TW Jr.

Methods Mol Biol. 2014;1076:371-417. doi: 10.1007/978-1-62703-649-8_16.


An introduction to fluorescence imaging techniques geared towards biosensor applications.

Goedhart J, Hink MA, Jalink K.

Methods Mol Biol. 2014;1071:17-28. doi: 10.1007/978-1-62703-622-1_2. Review.


Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location.

Goedhart J, van Unen J, Adjobo-Hermans MJ, Gadella TW Jr.

Sci Rep. 2013;3:2284. doi: 10.1038/srep02284.


The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides.

Gillis J, Schipper-Krom S, Juenemann K, Gruber A, Coolen S, van den Nieuwendijk R, van Veen H, Overkleeft H, Goedhart J, Kampinga HH, Reits EA.

J Biol Chem. 2013 Jun 14;288(24):17225-37. doi: 10.1074/jbc.M112.421685. Epub 2013 Apr 23.


PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

Adjobo-Hermans MJ, Crosby KC, Putyrski M, Bhageloe A, van Weeren L, Schultz C, Goedhart J, Gadella TW Jr.

Cell Signal. 2013 Jan;25(1):255-63. doi: 10.1016/j.cellsig.2012.09.022. Epub 2012 Sep 21.

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