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Items: 1 to 20 of 91


High temporal resolution gastric emptying breath tests in mice.

Miller KE, Bajzer Ž, Hein SS, Phillips JE, Syed S, Wright AM, Cipriani G, Gibbons SJ, Szurszewski JH, Farrugia G, Ordog T, Linden DR.

Neurogastroenterol Motil. 2018 Mar 25:e13333. doi: 10.1111/nmo.13333. [Epub ahead of print]


Not just there to fill space: profound observations on interstitial cells of Cajal in the gastric fundus.

Gibbons SJ.

J Physiol. 2018 May 1;596(9):1535-1536. doi: 10.1113/JP275923. Epub 2018 Apr 1. No abstract available.


Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice.

Cipriani G, Gibbons SJ, Miller KE, Yang DS, Terhaar ML, Eisenman ST, Ördög T, Linden DR, Gajdos GB, Szurszewski JH, Farrugia G.

Gastroenterology. 2018 Mar 6. pii: S0016-5085(18)30244-0. doi: 10.1053/j.gastro.2018.02.027. [Epub ahead of print]


Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity.

Strege PR, Mazzone A, Bernard CE, Neshatian L, Gibbons SJ, Saito YA, Tester DJ, Calvert ML, Mayer EA, Chang L, Ackerman MJ, Beyder A, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G494-G503. doi: 10.1152/ajpgi.00016.2017. Epub 2017 Nov 22.


Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis.

Gibbons SJ, Grover M, Choi KM, Wadhwa A, Zubair A, Wilson LA, Wu Y, Abell TL, Hasler WL, Koch KL, McCallum RW, Nguyen LAB, Parkman HP, Sarosiek I, Snape WJ, Tonascia J, Hamilton FA, Pasricha PJ, Farrugia G.

PLoS One. 2017 Nov 21;12(11):e0187772. doi: 10.1371/journal.pone.0187772. eCollection 2017.


Extracellular Cl- regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum.

Saravanaperumal SA, Gibbons SJ, Malysz J, Sha L, Linden DR, Szurszewski JH, Farrugia G.

Exp Physiol. 2018 Jan 1;103(1):40-57. doi: 10.1113/EP086367. Epub 2017 Nov 2.


Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

Hayashi Y, Toyomasu Y, Saravanaperumal SA, Bardsley MR, Smestad JA, Lorincz A, Eisenman ST, Cipriani G, Nelson Holte MH, Al Khazal FJ, Syed SA, Gajdos GB, Choi KM, Stoltz GJ, Miller KE, Kendrick ML, Rubin BP, Gibbons SJ, Bharucha AE, Linden DR, Maher LJ 3rd, Farrugia G, Ordog T.

Gastroenterology. 2017 Aug;153(2):521-535.e20. doi: 10.1053/j.gastro.2017.04.020. Epub 2017 Apr 21.


EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.

Strege PR, Gibbons SJ, Mazzone A, Bernard CE, Beyder A, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G572-G579. doi: 10.1152/ajpgi.00429.2016. Epub 2017 Mar 23.


Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

Grover M, Bernard CE, Pasricha PJ, Parkman HP, Gibbons SJ, Tonascia J, Koch KL, McCallum RW, Sarosiek I, Hasler WL, Nguyen LAB, Abell TL, Snape WJ, Kendrick ML, Kellogg TA, McKenzie TJ, Hamilton FA, Farrugia G; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13018. Epub 2017 Jan 9.


Restoration of density of interstitial cells of Cajal in the jejunum of diabetic rats after quercetin supplementation.

Vieira Frez FC, Martins Colombo Perles JV, Robert Linden D, Gibbons SJ, Amilcar Martins H, Almeida Brito Romualdo D, de Souza SR, Daion Piovezana Bossolani G, Zanoni JN.

Rev Esp Enferm Dig. 2017 Mar;109(3):190-195. doi: 10.17235/reed.2016.4338/2016.


Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine.

Malysz J, Gibbons SJ, Saravanaperumal SA, Du P, Eisenman ST, Cao C, Oh U, Saur D, Klein S, Ordog T, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G228-G245. doi: 10.1152/ajpgi.00363.2016. Epub 2016 Dec 15.


Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Apr 23;2(4):454-467. eCollection 2016 Jul.


Tumor necrosis factor alpha derived from classically activated "M1" macrophages reduces interstitial cell of Cajal numbers.

Eisenman ST, Gibbons SJ, Verhulst PJ, Cipriani G, Saur D, Farrugia G.

Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12984. Epub 2016 Oct 25.


Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis.

Bharucha AE, Daley SL, Low PA, Gibbons SJ, Choi KM, Camilleri M, Saw JJ, Farrugia G, Zinsmeister AR.

Neurogastroenterol Motil. 2016 Nov;28(11):1731-1740. doi: 10.1111/nmo.12874. Epub 2016 Jun 9.


Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.

Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, Leiter AB, Farrugia G, Beyder A.

J Physiol. 2017 Jan 1;595(1):79-91. doi: 10.1113/JP272718. Epub 2016 Aug 13.


Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility.

Cipriani G, Gibbons SJ, Kashyap PC, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Mar 1;2(2):120-130.e1.


Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying.

Cipriani G, Gibbons SJ, Verhulst PJ, Choi KM, Eisenman ST, Hein SS, Ordog T, Linden DR, Szurszewski JH, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):40-47.


Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.

Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G.

Neurogastroenterol Motil. 2016 Jan;28(1):64-73. doi: 10.1111/nmo.12697. Epub 2015 Oct 13.


A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

Strege PR, Bernard CE, Mazzone A, Linden DR, Beyder A, Gibbons SJ, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1;309(9):G743-9. doi: 10.1152/ajpgi.00074.2015. Epub 2015 Sep 10.


A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice.

Bajzer Ž, Gibbons SJ, Coleman HD, Linden DR, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G162-70. doi: 10.1152/ajpgi.00280.2014. Epub 2015 Jun 4.

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