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Items: 1 to 20 of 152


New insights emerging from recent investigations on human group II pyridoxal 5'-phosphate Decarboxylases.

Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M.

Curr Med Chem. 2016 Nov 22. [Epub ahead of print]


A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.

Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.


Invariant NKT cells are expanded in peripheral blood but are undetectable in salivary glands of patients with primary Sjögren's syndrome.

Guggino G, Ciccia F, Raimondo S, Giardina G, Alessandro R, Dieli F, Sireci G, Triolo G.

Clin Exp Rheumatol. 2016 Jan-Feb;34(1):25-31.


Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, Cutruzzolà F.

J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184.


In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.

Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S.

J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15.


Chest and breast MRI: the added value of a fast imaging for a new diagnostic approach in the planning of augmentation surgery in patients with thoracic asymmetries.

Rinaldi P, Parapatt GK, Giuliani M, Borelli C, Giardina GG, Fubelli R, Buccheri C, Tambasco D, Belli P, Salgarello M, Bonomo L.

Eur Rev Med Pharmacol Sci. 2015 Jul;19(13):2359-67.


Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis.

Ciccia F, Guggino G, Rizzo A, Manzo A, Vitolo B, La Manna MP, Giardina G, Sireci G, Dieli F, Montecucco CM, Alessandro R, Triolo G.

Rheumatology (Oxford). 2015 Dec;54(12):2264-72. doi: 10.1093/rheumatology/kev252.


Regular wine consumption in chronic heart failure: impact on outcomes, quality of life, and circulating biomarkers.

Cosmi F, Di Giulio P, Masson S, Finzi A, Marfisi RM, Cosmi D, Scarano M, Tognoni G, Maggioni AP, Porcu M, Boni S, Cutrupi G, Tavazzi L, Latini R; GISSI-HF Investigators..

Circ Heart Fail. 2015 May;8(3):428-37. doi: 10.1161/CIRCHEARTFAILURE.114.002091.


Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial.

Del Mastro L, De Placido S, Bruzzi P, De Laurentiis M, Boni C, Cavazzini G, Durando A, Turletti A, Nisticò C, Valle E, Garrone O, Puglisi F, Montemurro F, Barni S, Ardizzoni A, Gamucci T, Colantuoni G, Giuliano M, Gravina A, Papaldo P, Bighin C, Bisagni G, Forestieri V, Cognetti F; Gruppo Italiano Mammella (GIM) investigators..

Lancet. 2015 May 9;385(9980):1863-72. doi: 10.1016/S0140-6736(14)62048-1.


Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.

Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, Cutruzzolà F, Giardina G.

J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14.


Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.

ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028.


How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211.


Airway fistula closure after stem-cell infusion.

Petrella F, Spaggiari L, Acocella F, Barberis M, Bellomi M, Brizzola S, Donghi S, Giardina G, Giordano R, Guarize J, Lazzari L, Montemurro T, Pastano R, Rizzo S, Toffalorio F, Tosoni A, Zanotti M.

N Engl J Med. 2015 Jan 1;372(1):96-7. doi: 10.1056/NEJMc1411374. No abstract available.


SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.

Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482.


Nitrosylation of c heme in cd(1)-nitrite reductase is enhanced during catalysis.

Rinaldo S, Giardina G, Cutruzzolà F.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):449-54. doi: 10.1016/j.bbrc.2014.08.020.


Diffusion magnetic resonance imaging in breast cancer characterisation: correlations between the apparent diffusion coefficient and major prognostic factors.

Belli P, Costantini M, Bufi E, Giardina GG, Rinaldi P, Franceschini G, Bonomo L.

Radiol Med. 2015 Mar;120(3):268-76. doi: 10.1007/s11547-014-0442-8.


Distal-proximal crosstalk in the heme binding pocket of the NO sensor DNR.

Cutruzzolà F, Arcovito A, Giardina G, della Longa S, D'Angelo P, Rinaldo S.

Biometals. 2014 Aug;27(4):763-73. doi: 10.1007/s10534-014-9770-3.


Italian Study on Depressive Disorders (STudio Italiano MAlattia Depressiva, or STIMA-D): a nationwide snapshot of the status of treatment for major depression.

Aguglia E, Biggio G, Signorelli MS, Mencacci C; Steering Committee on behalf of the STIMA-D Investigators..

Pharmacopsychiatry. 2014 May;47(3):105-10. doi: 10.1055/s-0034-1375628.


The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis.

Guggino G, Giardina A, Ferrante A, Giardina G, Schinocca C, Sireci G, Dieli F, Ciccia F, Triolo G.

Rheumatol Int. 2015 Jan;35(1):171-5. doi: 10.1007/s00296-014-3030-2.


Targeting IL-6 signalling in early rheumatoid arthritis is followed by Th1 and Th17 suppression and Th2 expansion.

Guggino G, Giardina AR, Raimondo S, Giardina G, Sireci G, Dieli F, Peralta M, Alessandro R, Triolo G, Ciccia F.

Clin Exp Rheumatol. 2014 Jan-Feb;32(1):77-81.

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