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Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis.

Lazaridis LD, Pistiki A, Giamarellos-Bourboulis EJ, Georgitsi M, Damoraki G, Polymeros D, Dimitriadis GD, Triantafyllou K.

Dig Dis Sci. 2017 May 18. doi: 10.1007/s10620-017-4609-8. [Epub ahead of print]


Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction.

Ioakeimidou A, Pagalou E, Kontogiorgi M, Antoniadou E, Kaziani K, Psaroulis K, Giamarellos-Bourboulis EJ, Prekates A, Antonakos N, Lassale P, Gogos C; Hellenic Sepsis Study Group..

Eur J Clin Microbiol Infect Dis. 2017 Apr 28. doi: 10.1007/s10096-017-2988-6. [Epub ahead of print]


Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome.

Antonakos N, Tsaganos T, Oberle V, Tsangaris I, Lada M, Pistiki A, Machairas N, Souli M, Bauer M, Giamarellos-Bourboulis EJ.

Crit Care. 2017 Mar 9;21(1):48. doi: 10.1186/s13054-017-1625-1.


Dosing guidance for intravenous colistin in critically-ill patients.

Nation RL, Garonzik SM, Thamlikitkul V, Giamarellos-Bourboulis EJ, Forrest A, Paterson DL, Li J, Silveira FP.

Clin Infect Dis. 2016 Dec 23. pii: ciw839. doi: 10.1093/cid/ciw839. [Epub ahead of print]


Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control.

Kousathana F, Georgitsi M, Lambadiari V, Giamarellos-Bourboulis EJ, Dimitriadis G, Mouktaroudi M.

Cytokine. 2017 Feb;90:177-184. doi: 10.1016/j.cyto.2016.11.009. Epub 2016 Dec 3.


Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification.

Giamarellos-Bourboulis EJ, Tsaganos T, Tsangaris I, Lada M, Routsi C, Sinapidis D, Koupetori M, Bristianou M, Adamis G, Mandragos K, Dalekos GN, Kritselis I, Giannikopoulos G, Koutelidakis I, Pavlaki M, Antoniadou E, Vlachogiannis G, Koulouras V, Prekates A, Dimopoulos G, Koutsoukou A, Pnevmatikos I, Ioakeimidou A, Kotanidou A, Orfanos SE, Armaganidis A, Gogos C; Hellenic Sepsis Study Group..

Clin Microbiol Infect. 2017 Feb;23(2):104-109. doi: 10.1016/j.cmi.2016.11.003. Epub 2016 Nov 14.


Sepsis: Diagnostic and Therapeutic Challenges.

Molnár Z, Giamarellos-Bourboulis EJ, Kumar A, Nierhaus A.

Biomed Res Int. 2016;2016:5786182. Epub 2016 Oct 17. No abstract available.


Survival after multiple traumas is associated with improved outcomes from gram-negative sepsis: Clinical and experimental evidence.

Mandragos E, Pistiki A, Tsangaris I, Routsi C, Paraschos M, Droggiti DI, Savvidou O, Mastrokalos D, Papagelopoulos PJ, Netea MG, Giamarellos-Bourboulis EJ.

J Infect. 2017 Feb;74(2):163-171. doi: 10.1016/j.jinf.2016.10.007. Epub 2016 Nov 5.


Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection.

Tsaganos T, Tseti IK, Tziolos N, Soumelas GS, Koupetori M, Pyrpasopoulou A, Akinosoglou K, Gogos C, Tsokos N, Karagiannis A, Sympardi S, Giamarellos-Bourboulis EJ.

Br J Clin Pharmacol. 2017 Apr;83(4):742-750. doi: 10.1111/bcp.13173. Epub 2016 Dec 7.


Contemporary approaches to the rapid molecular diagnosis of sepsis.

Tziolos N, Giamarellos-Bourboulis EJ.

Expert Rev Mol Diagn. 2016 Nov;16(11):1201-1207. Epub 2016 Oct 21.


Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M.

EBioMedicine. 2016 Oct;12:227-238. doi: 10.1016/j.ebiom.2016.08.037. Epub 2016 Sep 15.


Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM.

EBioMedicine. 2016 Oct;12:239-246. doi: 10.1016/j.ebiom.2016.08.043. Epub 2016 Sep 15.


The role of genetics and antibodies in sepsis.

Giamarellos-Bourboulis EJ, Opal SM.

Ann Transl Med. 2016 Sep;4(17):328. Review.


Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa.

Kimball AB, Okun MM, Williams DA, Gottlieb AB, Papp KA, Zouboulis CC, Armstrong AW, Kerdel F, Gold MH, Forman SB, Korman NJ, Giamarellos-Bourboulis EJ, Crowley JJ, Lynde C, Reguiai Z, Prens EP, Alwawi E, Mostafa NM, Pinsky B, Sundaram M, Gu Y, Carlson DM, Jemec GB.

N Engl J Med. 2016 Aug 4;375(5):422-34. doi: 10.1056/NEJMoa1504370.


Systemic over-release of interleukin-17 in acute kidney injury after septic shock: Clinical and experimental evidence.

Maravitsa P, Adamopoulou M, Pistiki A, Netea MG, Louis K, Giamarellos-Bourboulis EJ.

Immunol Lett. 2016 Oct;178:68-76. doi: 10.1016/j.imlet.2016.08.002. Epub 2016 Aug 8.


Change of annexin binding of monocytes as an expression of cellular response to Candida albicans: down-regulation in severe sepsis.

Pistiki A, Tsaganos T, Tsangaris I, Antonakos N, Damoraki G, Giamarellos-Bourboulis EJ.

Eur J Clin Microbiol Infect Dis. 2016 Nov;35(11):1787-1793. Epub 2016 Aug 3.


Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage.

Giamarellos-Bourboulis EJ, Pyleris E, Barbatzas C, Pistiki A, Pimentel M.

BMC Gastroenterol. 2016 Jul 11;16(1):67. doi: 10.1186/s12876-016-0484-6.


Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition.

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 Aug 5;15(8):2394-406. doi: 10.1021/acs.jproteome.5b01065. Epub 2016 Jul 22.


A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis - A Prospective Multicenter Phase II Diagnostic Study.

Bauer M, Giamarellos-Bourboulis EJ, Kortgen A, Möller E, Felsmann K, Cavaillon JM, Guntinas-Lichius O, Rutschmann O, Ruryk A, Kohl M, Wlotzka B, Rußwurm S, Marshall JC, Reinhart K.

EBioMedicine. 2016 Apr;6:114-25. doi: 10.1016/j.ebiom.2016.03.006. Epub 2016 Mar 8.


High Copy Numbers of β-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.

Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K.

J Invest Dermatol. 2016 Aug;136(8):1592-8. doi: 10.1016/j.jid.2016.04.021. Epub 2016 May 7.


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