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Items: 1 to 20 of 143

1.

The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal.

Toma W, Kyte SL, Bagdas D, Jackson A, Meade JA, Rahman F, Chen ZJ, Del Fabbro E, Cantwell L, Kulkarni A, Thakur GA, Papke RL, Bigbee JW, Gewirtz DA, Damaj MI.

Exp Neurol. 2019 Jul 9;320:113010. doi: 10.1016/j.expneurol.2019.113010. [Epub ahead of print]

PMID:
31299179
2.

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy.

Saleh T, Tyutyunyk-Massey L, Gewirtz DA.

Cancer Res. 2019 Mar 15;79(6):1044-1046. doi: 10.1158/0008-5472.CAN-18-3437. Epub 2019 Feb 25.

PMID:
30803994
3.

Tumor cell escape from therapy-induced senescence.

Saleh T, Tyutyunyk-Massey L, Murray GF, Alotaibi MR, Kawale AS, Elsayed Z, Henderson SC, Yakovlev V, Elmore LW, Toor A, Harada H, Reed J, Landry JW, Gewirtz DA.

Biochem Pharmacol. 2019 Apr;162:202-212. doi: 10.1016/j.bcp.2018.12.013. Epub 2018 Dec 19.

PMID:
30576620
4.

Young plasma attenuates age-dependent liver ischemia reperfusion injury.

Liu A, Yang J, Hu Q, Dirsch O, Dahmen U, Zhang C, Gewirtz DA, Fang H, Sun J.

FASEB J. 2019 Feb;33(2):3063-3073. doi: 10.1096/fj.201801234R. Epub 2018 Nov 1.

PMID:
30383439
5.

Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy.

Xu J, Patel NH, Saleh T, Cudjoe EK Jr, Alotaibi M, Wu Y, Lima S, Hawkridge AM, Gewirtz DA.

Radiat Res. 2018 Nov;190(5):538-557. doi: 10.1667/RR15099.1. Epub 2018 Aug 22.

PMID:
30132722
6.

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.

Saleh T, Tyutynuk-Massey L, Cudjoe EK Jr, Idowu MO, Landry JW, Gewirtz DA.

Front Oncol. 2018 May 18;8:164. doi: 10.3389/fonc.2018.00164. eCollection 2018. Review.

7.

The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy.

Kyte SL, Gewirtz DA.

J Pharmacol Exp Ther. 2018 Aug;366(2):303-313. doi: 10.1124/jpet.118.249359. Epub 2018 Jun 4.

PMID:
29866790
8.

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy.

Aqbi HF, Tyutyunyk-Massey L, Keim RC, Butler SE, Thekkudan T, Joshi S, Smith TM, Bandyopadhyay D, Idowu MO, Bear HD, Payne KK, Gewirtz DA, Manjili MH.

Oncotarget. 2018 Apr 24;9(31):22113-22122. doi: 10.18632/oncotarget.25197. eCollection 2018 Apr 24.

9.

Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy.

Curry ZA, Wilkerson JL, Bagdas D, Kyte SL, Patel N, Donvito G, Mustafa MA, Poklis JL, Niphakis MJ, Hsu KL, Cravatt BF, Gewirtz DA, Damaj MI, Lichtman AH.

J Pharmacol Exp Ther. 2018 Jul;366(1):169-183. doi: 10.1124/jpet.117.245704. Epub 2018 Mar 14.

10.

The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy.

Gewirtz DA, Tyutyunyk-Massey L, Landry JW.

Biochem Pharmacol. 2018 Jul;153:46-50. doi: 10.1016/j.bcp.2018.01.048. Epub 2018 Feb 3. Review.

PMID:
29408462
11.

Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.

Liu A, Guo E, Yang J, Yang Y, Liu S, Jiang X, Hu Q, Dirsch O, Dahmen U, Zhang C, Gewirtz DA, Fang H.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12708. Epub 2017 Dec 5.

12.

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.

Kyte SL, Toma W, Bagdas D, Meade JA, Schurman LD, Lichtman AH, Chen ZJ, Del Fabbro E, Fang X, Bigbee JW, Damaj MI, Gewirtz DA.

J Pharmacol Exp Ther. 2018 Jan;364(1):110-119. doi: 10.1124/jpet.117.243972. Epub 2017 Oct 17.

13.

Proteomics Insights into Autophagy.

Cudjoe EK Jr, Saleh T, Hawkridge AM, Gewirtz DA.

Proteomics. 2017 Oct;17(20). doi: 10.1002/pmic.201700022. Review.

PMID:
28902446
14.

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes.

Rodriguez M, Lapierre J, Ojha CR, Estrada-Bueno H, Dever SM, Gewirtz DA, Kashanchi F, El-Hage N.

Viruses. 2017 Jul 28;9(8). pii: E201. doi: 10.3390/v9080201.

15.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

16.

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse.

Toma W, Kyte SL, Bagdas D, Alkhlaif Y, Alsharari SD, Lichtman AH, Chen ZJ, Del Fabbro E, Bigbee JW, Gewirtz DA, Damaj MI.

Neuropharmacology. 2017 May 1;117:305-315. doi: 10.1016/j.neuropharm.2017.02.020. Epub 2017 Feb 22.

17.

Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition.

Gewirtz DA, Alotaibi M, Yakovlev VA, Povirk LF.

Radiat Res. 2016 Oct;186(4):327-332. Epub 2016 Sep 2. Review.

18.

The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy.

Gewirtz DA.

Cancer Res. 2016 Oct 1;76(19):5610-5614. Epub 2016 Sep 15.

19.

Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer.

Saleh T, Cuttino L, Gewirtz DA.

Biochim Biophys Acta. 2016 Oct;1860(10):2130-6. doi: 10.1016/j.bbagen.2016.06.012. Epub 2016 Jun 15. Review.

20.

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells.

Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA.

Radiat Res. 2016 Mar;185(3):229-45. doi: 10.1667/RR14202.1. Epub 2016 Mar 2.

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