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Items: 1 to 20 of 157

1.

Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.

Opoku-Nsiah KA, Gestwicki JE.

Transl Res. 2018 Aug;198:48-57. doi: 10.1016/j.trsl.2018.05.002. Epub 2018 Jun 19. Review.

PMID:
30244692
2.

Inhibitors and chemical probes for molecular chaperone networks.

Gestwicki JE, Shao H.

J Biol Chem. 2018 Sep 13. pii: jbc.TM118.002813. doi: 10.1074/jbc.TM118.002813. [Epub ahead of print]

3.

The pleiotropic effects of TNF╬▒ in breast cancer subtypes is regulated by TNFAIP3/A20.

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H.

Oncogene. 2018 Aug 30. doi: 10.1038/s41388-018-0472-0. [Epub ahead of print]

PMID:
30166590
4.

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, Droop A, Chumas P, Short SC, Lorger M, Gestwicki JE, Roberts LD, Bon RS, Allison SJ, Zhu S, Markowetz F, Wurdak H.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaar2718. doi: 10.1126/scitranslmed.aar2718.

5.

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.

J Med Chem. 2018 Jul 26;61(14):6163-6177. doi: 10.1021/acs.jmedchem.8b00583. Epub 2018 Jul 13.

PMID:
29953808
6.

Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area.

Ran X, Gestwicki JE.

Curr Opin Chem Biol. 2018 Jun;44:75-86. doi: 10.1016/j.cbpa.2018.06.004. Epub 2018 Jun 13. Review.

PMID:
29908451
7.

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.

Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM.

JCI Insight. 2018 Jun 7;3(11). pii: 99319. doi: 10.1172/jci.insight.99319. [Epub ahead of print]

8.

Revisiting the "Art of the Chemical Probe".

Schwarz DMC, Gestwicki JE.

ACS Chem Biol. 2018 May 18;13(5):1109-1110. doi: 10.1021/acschembio.8b00390. No abstract available.

PMID:
29772907
9.

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.

Taylor IR, Ahmad A, Wu T, Nordhues BA, Bhullar A, Gestwicki JE, Zuiderweg ERP.

J Biol Chem. 2018 Jul 6;293(27):10796-10809. doi: 10.1074/jbc.RA118.002234. Epub 2018 May 15.

PMID:
29764935
10.

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.

Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe KE, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE 3rd, Kumar V, Malhotra SV, Weigel NL, Gestwicki JE, Trepel JB, Neckers LM.

Cancer Res. 2018 Jul 15;78(14):4022-4035. doi: 10.1158/0008-5472.CAN-17-3728. Epub 2018 May 15.

PMID:
29764864
11.

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.

PMID:
29728653
12.

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE.

Bioorg Med Chem. 2018 Apr 7. pii: S0968-0896(18)30354-7. doi: 10.1016/j.bmc.2018.04.018. [Epub ahead of print]

PMID:
29661622
13.

Protein-Protein Interactions in the Molecular Chaperone Network.

Freilich R, Arhar T, Abrams JL, Gestwicki JE.

Acc Chem Res. 2018 Apr 17;51(4):940-949. doi: 10.1021/acs.accounts.8b00036. Epub 2018 Apr 3.

PMID:
29613769
14.

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions.

Ouimet CM, Dawod M, Grinias J, Assimon VA, Lodge J, Mapp AK, Gestwicki JE, Kennedy RT.

Analyst. 2018 Apr 16;143(8):1805-1812. doi: 10.1039/C7AN02098H.

PMID:
29565056
15.

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.

Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L.

J Neurosci. 2018 Apr 11;38(15):3680-3688. doi: 10.1523/JNEUROSCI.2369-17.2018. Epub 2018 Mar 14.

PMID:
29540553
16.

High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.

Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE.

J Biol Chem. 2018 Mar 16;293(11):4014-4025. doi: 10.1074/jbc.RA117.001575. Epub 2018 Feb 2.

PMID:
29414793
17.

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE.

J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18.

18.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.

Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE.

Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28.

PMID:
28970360
19.

From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.

Pricer R, Gestwicki JE, Mapp AK.

Acc Chem Res. 2017 Mar 21;50(3):584-589. doi: 10.1021/acs.accounts.6b00565.

20.

The remarkable multivalency of the Hsp70 chaperones.

Zuiderweg ER, Hightower LE, Gestwicki JE.

Cell Stress Chaperones. 2017 Mar;22(2):173-189. doi: 10.1007/s12192-017-0776-y. Epub 2017 Feb 20. Review.

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