Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Gerontol A Biol Sci Med Sci. 2012 May;67(5):480-8. doi: 10.1093/gerona/gls090. Epub 2012 Mar 27.

Genes, environments, personality, and successful aging: toward a comprehensive developmental model in later life.

Author information

1
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA. nreaton@gmail.com

Abstract

BACKGROUND:

Outcomes in aging and health research, such as longevity, can be conceptualized as reflecting both genetic and environmental (nongenetic) effects. Parsing genetic and environmental influences can be challenging, particularly when taking a life span perspective, but an understanding of how genetic variants and environments relate to successful aging is critical to public health and intervention efforts.

METHODS:

We review the literature, and survey promising methods, to understand this interplay. We also propose the investigation of personality as a nexus connecting genetics, environments, and health outcomes.

RESULTS:

Personality traits may reflect psychological mechanisms by which underlying etiologic (genetic and environmental) effects predispose individuals to broad propensities to engage in (un)healthy patterns of behavior across the life span. In terms of methodology, traditional behavior genetic approaches have been used profitably to understand how genetic factors and environments relate to health and personality in somewhat separate literatures; we discuss how other behavior genetic approaches can help connect these literatures and provide new insights.

CONCLUSIONS:

Co-twin control designs can be employed to help determine causality via a closer approximation of the idealized counterfactual design. Gene-by-environment interaction (G × E) designs can be employed to understand how individual difference characteristics, such as personality, might moderate genetic and environmental influences on successful aging outcomes. Application of such methods can clarify the interplay of genes, environments, personality, and successful aging.

PMID:
22454369
PMCID:
PMC3326243
DOI:
10.1093/gerona/gls090
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center