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Items: 1 to 20 of 51

1.

Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity.

Boehm V, Britto-Borges T, Steckelberg AL, Singh KK, Gerbracht JV, Gueney E, Blazquez L, Altmüller J, Dieterich C, Gehring NH.

Mol Cell. 2018 Nov 1;72(3):482-495.e7. doi: 10.1016/j.molcel.2018.08.030.

PMID:
30388410
2.

The exon junction complex: structural insights into a faithful companion of mammalian mRNPs.

Gerbracht JV, Gehring NH.

Biochem Soc Trans. 2018 Feb 19;46(1):153-161. doi: 10.1042/BST20170059. Epub 2018 Jan 19. Review.

PMID:
29351963
3.

Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells.

Gerbracht JV, Boehm V, Gehring NH.

Sci Rep. 2017 Sep 6;7(1):10616. doi: 10.1038/s41598-017-10847-4.

4.

Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.

Ottens F, Boehm V, Sibley CR, Ule J, Gehring NH.

RNA. 2017 Aug;23(8):1224-1236. doi: 10.1261/rna.059659.116. Epub 2017 May 1.

5.

Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation.

Gehring NH, Wahle E, Fischer U.

Trends Biochem Sci. 2017 May;42(5):369-382. doi: 10.1016/j.tibs.2017.02.004. Epub 2017 Mar 6. Review.

PMID:
28268044
6.

Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.

Boehm V, Gerbracht JV, Marx MC, Gehring NH.

Nat Commun. 2016 Dec 5;7:13691. doi: 10.1038/ncomms13691.

7.
8.

Exon Junction Complexes: Supervising the Gene Expression Assembly Line.

Boehm V, Gehring NH.

Trends Genet. 2016 Nov;32(11):724-735. doi: 10.1016/j.tig.2016.09.003. Epub 2016 Sep 22. Review.

PMID:
27667727
9.

Physiological and pathophysiological role of nonsense-mediated mRNA decay.

Ottens F, Gehring NH.

Pflugers Arch. 2016 Jun;468(6):1013-28. doi: 10.1007/s00424-016-1826-5. Epub 2016 Apr 30. Review.

PMID:
27138169
10.

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.

Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH.

Nucleic Acids Res. 2016 Mar 18;44(5):2348-61. doi: 10.1093/nar/gkw009. Epub 2016 Jan 14.

11.

HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.

Ajamian L, Abel K, Rao S, Vyboh K, García-de-Gracia F, Soto-Rifo R, Kulozik AE, Gehring NH, Mouland AJ.

Biomolecules. 2015 Oct 20;5(4):2808-39. doi: 10.3390/biom5042808.

12.

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.

Fatscher T, Boehm V, Gehring NH.

Cell Mol Life Sci. 2015 Dec;72(23):4523-44. doi: 10.1007/s00018-015-2017-9. Epub 2015 Aug 18. Review.

PMID:
26283621
13.

mRNA metabolism and neuronal disease.

Linder B, Fischer U, Gehring NH.

FEBS Lett. 2015 Jun 22;589(14):1598-606. doi: 10.1016/j.febslet.2015.04.052. Epub 2015 May 13. Review.

14.

CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.

Steckelberg AL, Altmueller J, Dieterich C, Gehring NH.

Nucleic Acids Res. 2015 May 19;43(9):4687-700. doi: 10.1093/nar/gkv320. Epub 2015 Apr 13.

15.

The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.

Stockklausner C, Klotter AC, Dickemann N, Kuhlee IN, Duffert CM, Kerber C, Gehring NH, Kulozik AE.

Blood. 2015 Feb 12;125(7):1159-69. doi: 10.1182/blood-2014-07-587170. Epub 2014 Dec 23.

16.

3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons.

Boehm V, Haberman N, Ottens F, Ule J, Gehring NH.

Cell Rep. 2014 Oct 23;9(2):555-68. doi: 10.1016/j.celrep.2014.09.012. Epub 2014 Oct 9.

17.

The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.

Fatscher T, Boehm V, Weiche B, Gehring NH.

RNA. 2014 Oct;20(10):1579-92. doi: 10.1261/rna.044933.114. Epub 2014 Aug 21.

18.

NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins.

Burgute BD, Peche VS, Steckelberg AL, Glöckner G, Gaßen B, Gehring NH, Noegel AA.

Nucleic Acids Res. 2014 Mar;42(5):3177-93. doi: 10.1093/nar/gkt1311. Epub 2013 Dec 17.

19.

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2.

Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S.

Nucleic Acids Res. 2014 Feb;42(4):2673-86. doi: 10.1093/nar/gkt1197. Epub 2013 Nov 23.

20.

Studying the composition of mRNPs in vitro using splicing-competent cell extracts.

Steckelberg AL, Gehring NH.

Methods. 2014 Feb;65(3):342-9. doi: 10.1016/j.ymeth.2013.08.033. Epub 2013 Sep 8.

PMID:
24021717

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