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Redefining Signaling Pathways with an Expanding Single-Cell Toolbox.

Gaudet S, Miller-Jensen K.

Trends Biotechnol. 2016 Jun;34(6):458-69. doi: 10.1016/j.tibtech.2016.02.009. Review.


Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

Tan L, Wang J, Tanizaki J, Huang Z, Aref AR, Rusan M, Zhu SJ, Zhang Y, Ercan D, Liao RG, Capelletti M, Zhou W, Hur W, Kim N, Sim T, Gaudet S, Barbie DA, Yeh JR, Yun CH, Hammerman PS, Mohammadi M, Jänne PA, Gray NS.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77. doi: 10.1073/pnas.1403438111.


Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM.

Genes Dev. 2014 Sep 1;28(17):1957-75. doi: 10.1101/gad.241620.114.


A physical model of sprinting.

Gaudet S.

J Biomech. 2014 Sep 22;47(12):2933-40. doi: 10.1016/j.jbiomech.2014.07.012.


Cell-to-cell variability in cell death: can systems biology help us make sense of it all?

Xia X, Owen MS, Lee RE, Gaudet S.

Cell Death Dis. 2014 May 29;5:e1261. doi: 10.1038/cddis.2014.199. Review.


Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.

Lee RE, Walker SR, Savery K, Frank DA, Gaudet S.

Mol Cell. 2014 Mar 20;53(6):867-79. doi: 10.1016/j.molcel.2014.01.026.


Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, Maciag K, Chan EM, Silkworth W, Labowsky MT, Rozhansky L, Mesirov JP, Gillanders WE, Ogino S, Hacohen N, Gaudet S, Eck MJ, Engelman JA, Corcoran RB, Wong KK, Hahn WC, Barbie DA.

Cancer Discov. 2014 Apr;4(4):452-65. doi: 10.1158/2159-8290.CD-13-0646.


Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.

Gaudet S, Spencer SL, Chen WW, Sorger PK.

PLoS Comput Biol. 2012;8(4):e1002482. doi: 10.1371/journal.pcbi.1002482.


The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring.

Gaudet S, Langlois MJ, Lue RA, Rivard N, Viel A.

BMC Cell Biol. 2011 Dec 20;12:55. doi: 10.1186/1471-2121-12-55.


Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.

Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK.

Mol Syst Biol. 2011 Nov 22;7:553. doi: 10.1038/msb.2011.85.


Working after childbirth: a lifecourse transition analysis of Canadian women from the 1970s to the 2000s.

Gaudet S, Cooke M, Jacob J.

Can Rev Sociol. 2011 May;48(2):153-80.


Connecting cell fate decision networks in hematopoeisis from the outside in.

Gaudet S.

Mol Syst Biol. 2010 Oct 5;6:418. doi: 10.1038/msb.2010.75. No abstract available.


Systematic calibration of a cell signaling network model.

Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH.

BMC Bioinformatics. 2010 Apr 23;11:202. doi: 10.1186/1471-2105-11-202.


Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.

Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK.

Nature. 2009 May 21;459(7245):428-32. doi: 10.1038/nature08012.


[Psychosocial impact of the 1998 Québec Ice Storm.].

Charbonneau J, Ouellette FR, Gaudet S.

Sante Ment Que. 2000 Spring;25(1):138-62. French.


Collecting and organizing systematic sets of protein data.

Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S.

Nat Rev Mol Cell Biol. 2006 Nov;7(11):803-12. Review.


The response of human epithelial cells to TNF involves an inducible autocrine cascade.

Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK.

Cell. 2006 Mar 24;124(6):1225-39.


A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB.

Science. 2005 Dec 9;310(5754):1646-53.


A compendium of signals and responses triggered by prodeath and prosurvival cytokines.

Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK.

Mol Cell Proteomics. 2005 Oct;4(10):1569-90.


Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow.

El-Ali J, Gaudet S, Günther A, Sorger PK, Jensen KF.

Anal Chem. 2005 Jun 1;77(11):3629-36.

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