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Items: 1 to 20 of 48

1.

Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein.

Kacar B, Ge X, Sanyal S, Gaucher EA.

J Mol Evol. 2017 Mar;84(2-3):69-84. doi: 10.1007/s00239-017-9781-0. Epub 2017 Feb 23.

2.

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction.

Zakas PM, Brown HC, Knight K, Meeks SL, Spencer HT, Gaucher EA, Doering CB.

Nat Biotechnol. 2017 Jan;35(1):35-37. doi: 10.1038/nbt.3677. Epub 2016 Sep 26.

3.

An experimental phylogeny to benchmark ancestral sequence reconstruction.

Randall RN, Radford CE, Roof KA, Natarajan DK, Gaucher EA.

Nat Commun. 2016 Sep 15;7:12847. doi: 10.1038/ncomms12847.

4.

Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout.

Tan PK, Farrar JE, Gaucher EA, Miner JN.

Mol Biol Evol. 2016 Sep;33(9):2193-200. doi: 10.1093/molbev/msw116. Epub 2016 Jun 26.

5.

Selection for Protein Kinetic Stability Connects Denaturation Temperatures to Organismal Temperatures and Provides Clues to Archaean Life.

Romero-Romero ML, Risso VA, Martinez-Rodriguez S, Gaucher EA, Ibarra-Molero B, Sanchez-Ruiz JM.

PLoS One. 2016 Jun 2;11(6):e0156657. doi: 10.1371/journal.pone.0156657. eCollection 2016.

6.

Molecular Evolution Directs Protein Translation Using Unnatural Amino Acids.

Cox VE, Gaucher EA.

Curr Protoc Chem Biol. 2015 Dec 2;7(4):223-8. doi: 10.1002/9780470559277.ch150115. Review.

PMID:
26629613
7.

Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.

Risso VA, Manssour-Triedo F, Delgado-Delgado A, Arco R, Barroso-delJesus A, Ingles-Prieto A, Godoy-Ruiz R, Gavira JA, Gaucher EA, Ibarra-Molero B, Sanchez-Ruiz JM.

Mol Biol Evol. 2015 Feb;32(2):440-55. doi: 10.1093/molbev/msu312. Epub 2014 Nov 12.

8.

Engineering proteins by reconstructing evolutionary adaptive paths.

Cox VE, Gaucher EA.

Methods Mol Biol. 2014;1179:353-63. doi: 10.1007/978-1-4939-1053-3_24.

PMID:
25055790
9.

Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids.

Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA.

FASEB J. 2014 Aug;28(8):3339-50. doi: 10.1096/fj.13-243634. Epub 2014 Apr 22.

10.

Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins.

Risso VA, Gavira JA, Gaucher EA, Sanchez-Ruiz JM.

Proteins. 2014 Jun;82(6):887-96. doi: 10.1002/prot.24575. Epub 2014 Apr 18.

PMID:
24710963
11.

STRAD pseudokinases regulate axogenesis and LKB1 stability.

Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP.

Neural Dev. 2014 Mar 4;9:5. doi: 10.1186/1749-8104-9-5.

12.

Evolutionary history and metabolic insights of ancient mammalian uricases.

Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3763-8. doi: 10.1073/pnas.1320393111. Epub 2014 Feb 18.

13.

Conservation of protein structure over four billion years.

Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA.

Structure. 2013 Sep 3;21(9):1690-7. doi: 10.1016/j.str.2013.06.020. Epub 2013 Aug 8.

14.

Experimental evolution of protein-protein interaction networks.

Kaçar B, Gaucher EA.

Biochem J. 2013 Aug 1;453(3):311-9. doi: 10.1042/BJ20130205. Review.

15.

Secondary structure and domain architecture of the 23S and 5S rRNAs.

Petrov AS, Bernier CR, Hershkovits E, Xue Y, Waterbury CC, Hsiao C, Stepanov VG, Gaucher EA, Grover MA, Harvey SC, Hud NV, Wartell RM, Fox GE, Williams LD.

Nucleic Acids Res. 2013 Aug;41(15):7522-35. doi: 10.1093/nar/gkt513. Epub 2013 Jun 14.

16.

Reconstructing evolutionary adaptive paths for protein engineering.

Cole MF, Cox VE, Gratton KL, Gaucher EA.

Methods Mol Biol. 2013;978:115-25. doi: 10.1007/978-1-62703-293-3_8.

PMID:
23423892
17.

Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases.

Risso VA, Gavira JA, Mejia-Carmona DF, Gaucher EA, Sanchez-Ruiz JM.

J Am Chem Soc. 2013 Feb 27;135(8):2899-902. doi: 10.1021/ja311630a. Epub 2013 Feb 14. Erratum in: J Am Chem Soc. 2013 Jul 17;135(28):10580.

PMID:
23394108
18.

Interchanging functionality among homologous elongation factors using signatures of heterotachy.

Cacan E, Kratzer JT, Cole MF, Gaucher EA.

J Mol Evol. 2013 Feb;76(1-2):4-12. doi: 10.1007/s00239-013-9540-9. Epub 2013 Jan 31.

19.

Hydrophobic environment is a key factor for the stability of thermophilic proteins.

Gromiha MM, Pathak MC, Saraboji K, Ortlund EA, Gaucher EA.

Proteins. 2013 Apr;81(4):715-21. doi: 10.1002/prot.24232. Epub 2013 Jan 15.

PMID:
23319168

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