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Items: 16


A research agenda for malaria eradication: vaccines.

malERA Consultative Group on Vaccines.

PLoS Med. 2011 Jan 25;8(1):e1000398. doi: 10.1371/journal.pmed.1000398. Review.


Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.

J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757.


Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA.

J Med Chem. 2009 Mar 12;52(5):1408-15. doi: 10.1021/jm8012618.


Effect of the haematocrit layer geometry on Plasmodium falciparum static thin-layer in vitro cultures.

Ferrer J, Rosal MD, Vidal JM, Prats C, Valls J, Herreros EA, López D, Gargallo D.

Malar J. 2008 Oct 8;7:203. doi: 10.1186/1475-2875-7-203.


Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.

J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15.


Individual-based model and simulation of Plasmodium falciparum infected erythrocyte in vitro cultures.

Ferrer J, Vidal J, Prats C, Valls J, Herreros E, Lopez D, Giró A, Gargallo D.

J Theor Biol. 2007 Oct 7;248(3):448-59. Epub 2007 Jun 2.


Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor.

Xiang H, McSurdy-Freed J, Moorthy GS, Hugger E, Bambal R, Han C, Ferrer S, Gargallo D, Davis CB.

J Pharm Sci. 2006 Dec;95(12):2657-72.


Computer-assisted enhanced volumetric segmentation magnetic resonance imaging data using a mixture of artificial neural networks.

Pérez de Alejo R, Ruiz-Cabello J, Cortijo M, Rodriguez I, Echave I, Regadera J, Arrazola J, Avilés P, Barreiro P, Gargallo D, Graña M.

Magn Reson Imaging. 2003 Oct;21(8):901-12.


Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production.

Angulo I, Jiménez-Díaz MB, García-Bustos JF, Gargallo D, de las Heras FG, Muñoz-Fernández MA, Fresno M.

Cell Immunol. 2002 Jul-Aug;218(1-2):46-58.


Monitoring acute inflammatory processes in mouse muscle by MR imaging and spectroscopy: a comparison with pathological results.

Ruiz-Cabello J, Regadera J, Santisteban C, Graña M, Pérez de Alejo R, Echave I, Avilés P, Rodriguez I, Santos I, Gargallo D, Cortijo M.

NMR Biomed. 2002 May;15(3):204-14.


Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice.

Angulo I, de las Heras FG, García-Bustos JF, Gargallo D, Muñoz-Fernández MA, Fresno M.

Blood. 2000 Jan 1;95(1):212-20.


Bacteriocin 28b, a chromosomally encoded bacteriocin produced by most Serratia marcescens biotypes.

Guasch JF, Enfedaque J, Ferrer S, Gargallo D, Regué M.

Res Microbiol. 1995 Jul-Aug;146(6):477-83.


Cloning and DNA sequence analysis of a bacteriocin gene of Serratia marcescens.

Viejo MB, Gargallo D, Ferrer S, Enfedaque J, Regué M.

J Gen Microbiol. 1992 Aug;138 Pt 8:1737-43.


Activity of E-3846, a new fluoroquinolone, in vitro and in experimental cystitis and pyelonephritis in rats.

Gargallo D, Moros M, Coll R, Esteve M, Parés J, Xicota MA, Guinea J.

Antimicrob Agents Chemother. 1988 May;32(5):636-41.


Glucose-6-phosphate dehydrogenase alloenzymes and their relationship to pigmentation in Serratia marcescens.

Gargallo D, Lorén JG, Guinea J, Viñas M.

Appl Environ Microbiol. 1987 Aug;53(8):1983-6.


Morphological characterization of the Serratia marcescens bacteriophage SLP.

Viñas MC, Gargallo D, Lorén JG, Guinea J.

J Basic Microbiol. 1985;25(4):285-8.


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