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Items: 1 to 20 of 115


The epidemiology and genetics of Amyotrophic lateral sclerosis in China.

Liu X, He J, Gao FB, Gitler AD, Fan D.

Brain Res. 2018 Mar 1. pii: S0006-8993(18)30105-7. doi: 10.1016/j.brainres.2018.02.035. [Epub ahead of print]


The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.

West RJH, Ugbode C, Gao FB, Sweeney ST.

Hum Mol Genet. 2018 Apr 15;27(8):1382-1395. doi: 10.1093/hmg/ddy048.


Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.

Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW.

Cell. 2018 Jan 25;172(3):590-604.e13. doi: 10.1016/j.cell.2017.12.032.


Rethinking Unconventional Translation in Neurodegeneration.

Gao FB, Richter JD, Cleveland DW.

Cell. 2017 Nov 16;171(5):994-1000. doi: 10.1016/j.cell.2017.10.042.


Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.

Gao FB, Almeida S, Lopez-Gonzalez R.

EMBO J. 2017 Oct 16;36(20):2931-2950. doi: 10.15252/embj.201797568. Epub 2017 Sep 15. Review.


Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay.

Chen L, Leng WB, Li Z, Xia HW, Ren M, Tang QL, Gong QY, Gao FB, Bi F.

Sci Rep. 2017 Aug 30;7(1):9945. doi: 10.1038/s41598-017-08358-3.


The lysosomal protein cathepsin L is a progranulin protease.

Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L.

Mol Neurodegener. 2017 Jul 25;12(1):55. doi: 10.1186/s13024-017-0196-6.


Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.

Yin S, Lopez-Gonzalez R, Kunz RC, Gangopadhyay J, Borufka C, Gygi SP, Gao FB, Reed R.

Cell Rep. 2017 Jun 13;19(11):2244-2256. doi: 10.1016/j.celrep.2017.05.056.


A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.

Wu CH, Giampetruzzi A, Tran H, Fallini C, Gao FB, Landers JE.

Hum Mol Genet. 2017 Jun 1;26(11):2146-2155. doi: 10.1093/hmg/ddx112.


Microsatellite Expansion Diseases: Repeat Toxicity Found in Translation.

Gao FB, Richter JD.

Neuron. 2017 Jan 18;93(2):249-251. doi: 10.1016/j.neuron.2017.01.001.


Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons.

Lopez-Gonzalez R, Lu Y, Gendron TF, Karydas A, Tran H, Yang D, Petrucelli L, Miller BL, Almeida S, Gao FB.

Neuron. 2016 Oct 19;92(2):383-391. doi: 10.1016/j.neuron.2016.09.015. Epub 2016 Oct 6.


Autophagy in neurodegenerative diseases.

Lee JA, Yue Z, Gao FB.

Brain Res. 2016 Oct 15;1649(Pt B):141-142. doi: 10.1016/j.brainres.2016.09.030. No abstract available.


MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.

Biswas MHU, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB.

Stem Cell Reports. 2016 Sep 13;7(3):316-324. doi: 10.1016/j.stemcr.2016.08.006. Epub 2016 Sep 1.


Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.

Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.


Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.

Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD.

Science. 2016 Aug 12;353(6300):708-12. doi: 10.1126/science.aaf7791.


Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat.

Qin Y, Li GL, Xu XH, Sun ZY, Gu JW, Gao FB.

Behav Brain Res. 2018 Mar 15;340:41-48. doi: 10.1016/j.bbr.2016.08.008. Epub 2016 Aug 4.


A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes.

Swartz EW, Baek J, Pribadi M, Wojta KJ, Almeida S, Karydas A, Gao FB, Miller BL, Coppola G.

Stem Cells Transl Med. 2016 Nov;5(11):1461-1472. doi: 10.5966/sctm.2015-0340. Epub 2016 Jul 1.


Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD.

Almeida S, Gao FB.

EMBO J. 2016 Jun 15;35(12):1251-3. doi: 10.15252/embj.201694578. Epub 2016 May 6. No abstract available.


Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients.

Almeida S, Gao F, Coppola G, Gao FB.

Neurobiol Aging. 2016 Jun;42:35-40. doi: 10.1016/j.neurobiolaging.2016.03.001. Epub 2016 Mar 9.


Dynamic Diffusion Tensor Imaging Reveals Structural Changes in the Bilateral Pyramidal Tracts after Brain Stem Hemorrhage in Rats.

Zhang RZ, Tao CY, Chen W, Wang CH, Hu Y, Song L, Zhang B, Chen YS, Xu ZQ, Wang L, Feng H, Wang TH, Zheng J, You C, Gao FB.

Front Neuroanat. 2016 Mar 30;10:33. doi: 10.3389/fnana.2016.00033. eCollection 2016.

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