Format

Send to

Choose Destination

Best matches for Gadolinium coated HSA transferrin nanoparticles rodentia:

Transferrin-coated gadolinium nanoparticles as MRI contrast agent. Korkusuz H et al. Mol Imaging Biol. (2013)

See comment in PubMed Commons below
Mol Imaging Biol. 2013 Apr;15(2):148-54. doi: 10.1007/s11307-012-0579-6.

Transferrin-coated gadolinium nanoparticles as MRI contrast agent.

Author information

1
Department of Nuclear Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt/Main, Germany. huedayi.korkusuz@kgu.de

Abstract

PURPOSE:

In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated.

PROCEDURES:

HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-HSA-NP-Tf). Mice underwent MRI before or after injection of Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-Tf.

RESULTS:

All the studied contrast agents provided a contrast enhancement (CE) in the blood, heart muscle, and liver. Compared to Gd-DTPA, CE with HSA-NP was achieved at lower Gd doses. Gd-HSA-NP-Tf yielded significantly higher CE than Gd-HSA-NP in the skeletal muscle, blood, cardiac muscle, and liver (p < 0.05). Gd-HSA-NP-Tf achieved a significantly higher CE than Gd-HSA-NP and Gd-DTPA in the blood, cardiac muscle, and liver (p < 0.05). In the brain, only Gd-HSA-NP-Tf was found to cause a significant CE (p < 0.05).

CONCLUSIONS:

The Gd-HSA nanoparticles have potential as MRI contrast agents. In particular, Gd-HSA-NP-Tf has a potential as a specific contrast agent for the brain, while the blood-brain barrier is still intact, as well as in the heart, liver, and skeletal muscle.

PMID:
22811020
DOI:
10.1007/s11307-012-0579-6
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center