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Page 1
Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios.
Kim SA, Kim JH, Park M, Cho IH, Yoo HJ. Kim SA, et al. Neurosci Res. 2007 Jul;58(3):332-5. doi: 10.1016/j.neures.2007.03.002. Epub 2007 Mar 13. Neurosci Res. 2007. PMID: 17428563
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. ...These results suggest a potential association between GRIK2 and ASD in the Korean population....
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. ...These …
Glutamate receptor 6 gene (GluR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder.
Dutta S, Das S, Guhathakurta S, Sen B, Sinha S, Chatterjee A, Ghosh S, Ahmed S, Ghosh S, Usha R. Dutta S, et al. Cell Mol Neurobiol. 2007 Dec;27(8):1035-47. doi: 10.1007/s10571-007-9193-6. Epub 2007 Aug 22. Cell Mol Neurobiol. 2007. PMID: 17712621
Autism is a neurodevelopmental disorder with early manifestation. It is a multifactorial disorder and several susceptible chromosomal regions for autism are identified through genome scan studies. ...
Autism is a neurodevelopmental disorder with early manifestation. It is a multifactorial disorder and several susceptib …
Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population.
Xie X, Hou F, Li L, Chen Y, Liu L, Luo X, Gu H, Li X, Zhang J, Gong J, Song R. Xie X, et al. Psychiatry Investig. 2019 May;16(5):379-385. doi: 10.30773/pi.2019.02.26.3. Epub 2019 May 23. Psychiatry Investig. 2019. PMID: 31132842 Free PMC article.
OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. ...RESULTS: The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of hum …
OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. ...RES …
Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.
Delorme R, Krebs MO, Chabane N, Roy I, Millet B, Mouren-Simeoni MC, Maier W, Bourgeron T, Leboyer M. Delorme R, et al. Neuroreport. 2004 Mar 22;15(4):699-702. doi: 10.1097/00001756-200403220-00025. Neuroreport. 2004. PMID: 15094479
Only the GRIK2 SNP I867, recently associated with autism, was less transmitted than expected (p < 0.03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD....

Only the GRIK2 SNP I867, recently associated with autism, was less transmitted than expected (p < 0.03), supporting a funct

…
Both rare and common genetic variants contribute to autism in the Faroe Islands.
Leblond CS, Cliquet F, Carton C, Huguet G, Mathieu A, Kergrohen T, Buratti J, Lemière N, Cuisset L, Bienvenu T, Boland A, Deleuze JF, Stora T, Biskupstoe R, Halling J, Andorsdóttir G, Billstedt E, Gillberg C, Bourgeron T. Leblond CS, et al. NPJ Genom Med. 2019 Jan 21;4:1. doi: 10.1038/s41525-018-0075-2. eCollection 2019. NPJ Genom Med. 2019. PMID: 30675382 Free PMC article.
Here, we investigated 357 individuals from the Faroe Islands including 36 individuals with autism, 136 of their relatives and 185 non-autism controls. Data from SNP array and whole exome sequencing revealed that individuals with autism had a higher burden of …
Here, we investigated 357 individuals from the Faroe Islands including 36 individuals with autism, 136 of their relatives and 185 non …
Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
Bah J, Quach H, Ebstein RP, Segman RH, Melke J, Jamain S, Rietschel M, Modai I, Kanas K, Karni O, Lerer B, Gourion D, Krebs MO, Etain B, Schürhoff F, Szöke A, Leboyer M, Bourgeron T. Bah J, et al. Neuroreport. 2004 Aug 26;15(12):1987-91. doi: 10.1097/00001756-200408260-00031. Neuroreport. 2004. PMID: 15305151
In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. ...These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of …
In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. ...These resu …
Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder.
Kainer D, Templeton AR, Prates ET, Jacboson D, Allan ERO, Climer S, Garvin MR. Kainer D, et al. HGG Adv. 2022 Oct 6;4(1):100150. doi: 10.1016/j.xhgg.2022.100150. eCollection 2023 Jan 12. HGG Adv. 2022. PMID: 36340933 Free PMC article.
The heritability of autism spectrum disorder (ASD), based on 680,000 families and five countries, is estimated to be nearly 80%, yet heritability reported from SNP-based studies are consistently lower, and few significant loci have been identified with genome …
The heritability of autism spectrum disorder (ASD), based on 680,000 families and five countries, is estimated to be ne …
Impaired hippocampus-dependent spatial flexibility and sociability represent autism-like phenotypes in GluK2 mice.
Micheau J, Vimeney A, Normand E, Mulle C, Riedel G. Micheau J, et al. Hippocampus. 2014 Sep;24(9):1059-69. doi: 10.1002/hipo.22290. Epub 2014 Apr 30. Hippocampus. 2014. PMID: 24753134
Autism is a complex neurodevelopmental disorder with high heritability. grik2 (which encodes the GluK2 subunit of kainate receptors) has been identified as a susceptibility gene in Autism Spectrum Disorders (ASD), but its role in the core and as …
Autism is a complex neurodevelopmental disorder with high heritability. grik2 (which encodes the GluK2 subunit of kaina …
Linkage and candidate gene studies of autism spectrum disorders in European populations.
Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP; EU Autism MOLGEN Consortium. Holt R, et al. Eur J Hum Genet. 2010 Sep;18(9):1013-9. doi: 10.1038/ejhg.2010.69. Epub 2010 May 5. Eur J Hum Genet. 2010. PMID: 20442744 Free PMC article.
Association analysis showed significant associations in MKL2 with ASD (rs756472, P=4.31 x 10(-5)) and between SND1 and strict autism (rs1881084, P=7.76 x 10(-5)) in the Finnish and Northern Dutch populations, respectively. ...Further increasing the sample size stren …
Association analysis showed significant associations in MKL2 with ASD (rs756472, P=4.31 x 10(-5)) and between SND1 and strict auti …
Linkage and association of the glutamate receptor 6 gene with autism.
Jamain S, Betancur C, Quach H, Philippe A, Fellous M, Giros B, Gillberg C, Leboyer M, Bourgeron T; Paris Autism Research International Sibpair (PARIS) Study. Jamain S, et al. Mol Psychiatry. 2002;7(3):302-10. doi: 10.1038/sj.mp.4000979. Mol Psychiatry. 2002. PMID: 11920157 Free PMC article.
A genome scan was previously performed and pointed to chromosome 6q21 as a candidate region for autism. This region contains the glutamate receptor 6 (GluR6 or GRIK2) gene, a functional candidate for the syndrome. ...Taken together, these data suggest that GluR6 is …
A genome scan was previously performed and pointed to chromosome 6q21 as a candidate region for autism. This region contains the glut …
15 results